<i>HIF-1α</i> rs11549465 C&gt;T polymorphism contributes to increased cancer susceptibility: Evidence from 49 studies

Li, Hunian; He, Ting; Zha, Yong-Jiu; Du, Fang; Liu, Jie; Lin, Huiran; Yang, Wen-Zi

doi:10.7150/jca.35716

Cited by 11 publications

(6 citation statements)

References 53 publications

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“…HIF-associated SNPs were also explored in lung cancer susceptibility. HIF-1α SNP rs11549465 was associated with overall cancer risk including lung cancer risk, in a meta-analysis based on 26 383 patients, equally distributed between controls and cases [ 218 ]. In another meta-analysis, SNP rs11549465 was also associated with higher overall cancer risk among 16,440 patients [ 119 ].…”

Section: Prognostic Implications Of Hypoxia In Lung Cancermentioning

confidence: 99%

Hypoxia in Lung Cancer Management: A Translational Approach

Ancel

Perotin

Dewolf

et al. 2021

Cancers

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Lung cancer represents the first cause of death by cancer worldwide and remains a challenging public health issue. Hypoxia, as a relevant biomarker, has raised high expectations for clinical practice. Here, we review clinical and pathological features related to hypoxic lung tumours. Secondly, we expound on the main current techniques to evaluate hypoxic status in NSCLC focusing on positive emission tomography. We present existing alternative experimental approaches such as the examination of circulating markers and highlight the interest in non-invasive markers. Finally, we evaluate the relevance of investigating hypoxia in lung cancer management as a companion biomarker at various lung cancer stages. Hypoxia could support the identification of patients with higher risks of NSCLC. Moreover, the presence of hypoxia in treated tumours could help clinicians predict a worse prognosis for patients with resected NSCLC and may help identify patients who would benefit potentially from adjuvant therapies. Globally, the large quantity of translational data incites experimental and clinical studies to implement the characterisation of hypoxia in clinical NSCLC management.

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Section: Prognostic Implications Of Hypoxia In Lung Cancermentioning

confidence: 99%

Hypoxia in Lung Cancer Management: A Translational Approach

Ancel

Perotin

Dewolf

et al. 2021

Cancers

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“…They observed that the TT genotype may modulate the gynecologic cancer (OR = 9.92; 95% CI = 2.15–45.66) risk compared with the CC genotype. Moreover, in a meta‐analysis by Li et al, systematic evaluation of the relationship between rs11549465 and cancer risk in 49 case–control studies 24 indicated that rs11549465 was significantly related to the increased risk of overall cancer under four genetic models ( TT vs. CC : OR = 2.06; 95% CI = 1.34–3.16, TT vs. CC / CT : OR = 2.42; 95% CI = 1.60–3.65, CT / TT vs. CC : OR = 1.21; 95% CI = 1.04–1.40, T vs. C : OR = 1.29, 95% CI = 1.12–1.48). Therefore, these meta‐analyses supported the results of Tanimoto suggesting that rs11549465 affects the cancer risk by promoting angiogenesis.…”

Section: Discussionmentioning

confidence: 99%

“…We preliminarily observed inhibition of MSTN expression in the compressed rat skin, suggesting that inhibition of MSTN expression enhances the regeneration of skeletal muscle after pressure loading 23 . Several SNPs in these genes have been identified and associated with diseases 24‐28 . Therefore, studies of individual variance among these factors may lead to the identification of PI susceptibilities and suggest preventive care that would directly target the pathways involved in PI development.…”

Section: Introductionmentioning

confidence: 99%

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Polymorphism analysis of candidate risk genes for pressure injuries in older Japanese patients: A cross‐sectional study at a long‐term care hospital

Tsukatani

Minematsu

Dai

et al. 2021

Wound Repair Regeneration

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Advances in patient care for pressure injuries (PIs) have reduced the prevalence of PIs in Japan, although not in recent years. Several single-nucleotide polymorphisms (SNPs) have been identified in genes potentially associated with PIs. However, individual variance among PI risks require targeted investigations that may lead to the identification of PI susceptibilities or preventive care options that directly influence PI development pathways. This cross-sectional study examined the association between PIs and SNPs in genes related to tissue tolerance in patients in a long-term care hospital in Japan. A total of 178 participants (130 control, 20 with superficial PI history, and 28 with deep PI history) were enrolled in this study of eight SNPs in hypoxia inducible factor 1 subunit alpha (HIF1A), vascular endothelial growth factor C (VEGFC), heat shock protein 90 alpha family class A member 1 (HSP90AA1), myostatin (MSTN), and vitamin D receptor (VDR). The primary outcome was a history of superficial and deep PIs in the last 6 months. SNPs were examined by real-time polymerase chain reaction, followed by multivariate logistic regression analyses of the associations between the SNPs and PI history. The results showed a significant association between VEGFC rs1485766 and the history of superficial PIs (odds ratio = 2.95; 95% confidence interval = 1.07-8.11; p = 0.04). Stratified analysis using the Braden Scale (≤14) indicated a significant association between HIF1A rs11549465 and deep PIs (p = 0.04). Our study demonstrated that VEGFC rs1485766 and HIF1A rs11549465 were associated with superficial and deep PI susceptibilities, respectively.disease susceptibility, hypoxia-inducible factor 1, single-nucleotide polymorphism, vascular endothelial growth factor C | INTRODUCTIONA pressure injury (PI) is defined as a localized injury to the skin and/or underlying tissue caused by external forces. 1 Compared with the prevalence of PIs, which range from 2.8% to 28.8% in the United States 2 and 3.4% to 14.5% in Germany and Sweden, 3 Japan has a relatively low PI prevalence, which ranges from 0.77% to 2.81% (Survey of the Japanese Society of Pressure Ulcers, 2018). PIs reduce the quality of life of patients owing to the pain and discomfort they cause. 4 Furthermore, failure to heal in patients leads to higher mortality rates and an

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“…The role of HIF-1α rs2057482 has not yet been investigated in cancer disease. Conversely, HIF-1α rs11158358 C was considered as risk factor in Chinese women with cervical cancer (25) and rs11549465 C contributes to increased cancer susceptibility according the literature (26).…”

Section: Discussionmentioning

confidence: 99%

The role of angiogenetic single-nucleotide polymorphisms in thymic malignancies and thymic benign lesions

Berardi¹,

Goteri²,

Pagliaretta³

et al. 2020

J Thorac Dis

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Background: We previously showed that selected single-nucleotide-polymorphisms (SNPs) of genes involved in angiogenesis influence the aggressiveness of thymic epithelial tumors (TETs). This study analyzes their role in TETs and in thymic benign lesions, in order to investigate potential correlation with risk and outcome. Methods: Genomic DNA was extracted from paraffin-embedded tissue of 92 patients, undergoing surgery at our Institution. We investigated by Real-Time PCR the SNPs of the following genes: platelet-derived growth factor receptor-α (PDGFRα), hypoxia-inducible factor-1α (HIF-1α), vascular endothelial growth factor A (VEGF-A), vascular endothelial growth factor receptor-2 and 3 (VEGF-2, VEGFR-3), excision repair cross-complementation group-1 (ERCC1). Results: Fifty-seven TETs and 35 thymic benign lesions were included into the study. Frequency of SNPs was as follows: rs2057482 C, rs11158358 C and rs11549465 C polymorphisms of HIF1-a: thymomas < general population (P=0.008, P=0.007, and P=0.044 respectively). HIF1-a alleles: general population > study groups, rs1951795C SNP (P=0.026 for benign lesions and P=0.0007 for thymomas), rs10873142T SNP (P=0.008 and P=0.001 respectively), rs12434438 A SNP (P=0.034 and P=0.0007) and rs2301113A SNP (P=0.027 and P=0.010). rs699947C polymorphism of VEGF-A: benign lesions > general population (P=0.012). Conclusions: This is the first study investigating the angiogenetic polymorphisms in thymic benign lesions and TETs. SNPs analysis may represent a further asset in identification of patients who could benefit from anti-angiogenetic therapy.

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HIF-1α rs11549465 C>T polymorphism contributes to increased cancer susceptibility: Evidence from 49 studies

Cited by 11 publications

References 53 publications

Hypoxia in Lung Cancer Management: A Translational Approach

Hypoxia in Lung Cancer Management: A Translational Approach

Polymorphism analysis of candidate risk genes for pressure injuries in older Japanese patients: A cross‐sectional study at a long‐term care hospital

The role of angiogenetic single-nucleotide polymorphisms in thymic malignancies and thymic benign lesions

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