<i>Hippophae rhamnoides</i> L. leaf extracts alleviate diabetic nephropathy <i>via</i> attenuation of advanced glycation end product-induced oxidative stress in db/db mice

Gu, Min Ji; Lee, Hee-Weon; Yoo, Guijae; Kim, Donghwan; Kim, Yoonsook; Choi, In-Wook; Cha, Youn-Soo; Ha, Sang Keun

doi:10.1039/d3fo01364b

Food Funct.

2023

DOI: 10.1039/d3fo01364b

|View full text |Cite

Hippophae rhamnoides L. leaf extracts alleviate diabetic nephropathy via attenuation of advanced glycation end product-induced oxidative stress in db/db mice

Min Ji Gu,

Hee-Weon Lee,

Guijae Yoo

et al.

Abstract: In diabetes, excessive formation and accumulation of advanced glycation end products induce oxidative stress, leading to chronic renal failure. The leaves of Hippophae rhamnoides L. (SBL) attenuated oxidative stress by modulating the AGEs-RAGE axis.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

2025

Publication Types

Select...

Article4

Relationship

Self Cite0

Independent4

Authors

Journals

Cited by 4 publications

References 68 publications

(84 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

Effect of advanced glycation end-products in a wide range of medical problems including COVID-19

Bronowicka-Szydełko,

Gostomska-Pampuch,

Kuzan

et al. 2024

Advances in Medical Sciences

View full text Add to dashboard Cite

Effect of advanced glycation end-products in a wide range of medical problems including COVID-19

Bronowicka-Szydełko,

Gostomska-Pampuch,

Kuzan

et al. 2024

Advances in Medical Sciences

View full text Add to dashboard Cite

Quality differences in sea buckthorn (Hippophaë rhamnoides L.) berries of major varieties in China based on key components and antioxidant activity

Zheng,

Sun,

Sun

et al. 2025

Food Chemistry

View full text Add to dashboard Cite

Research progress of sea buckthorn (Hippophae rhamnoides L.) in prevention and treatment of cardiovascular disease

Chen,

He,

Cao

et al. 2024

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

Sea buckthorn (Hippophae rhamnoides L.) contains a variety of biologically active compounds, including flavonoids, terpenoids, polysaccharides, organic acids, volatile oils, and vitamins. It has been demonstrated to be effective in the treatment of cardiovascular disorders. In this paper, we evaluated the pharmacological effects of sea buckthorn in cardiovascular diseases through preclinical studies, and revealed the mechanism of action of the active components in sea buckthorn in cardiovascular diseases, including anti-inflammatory, lipid oxidation regulation, antioxidant, vascular function modulation, anti-platelet aggregation, autophagy, intestinal microorganism regulation, and cell apoptosis reduction. In clinical trials, sea buckthorn was proven to be effective in managing lipid metabolism, blood pressure, and blood glucose levels in patients. We also extensively reviewed the safety of sea buckthorn medicine and its toxicity to numerous organs. To summarize, sea buckthorn has a beneficial effect on cardiovascular disease and may give a novel strategy for clinical intervention and therapy. This paper summarizes the phytochemistry, pharmacology, clinical applications, safety, and toxicity of sea buckthorn in order to better understand the mechanism of action of the various bioactive components in sea buckthorn, investigate its medicinal potential, and provide more options for the treatment of cardiovascular diseases.

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

This site is protected by reCAPTCHA and the Google Privacy Policy and Terms of Service apply.

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Hippophae rhamnoides L. leaf extracts alleviate diabetic nephropathy via attenuation of advanced glycation end product-induced oxidative stress in db/db mice

Abstract: In diabetes, excessive formation and accumulation of advanced glycation end products induce oxidative stress, leading to chronic renal failure. The leaves of Hippophae rhamnoides L. (SBL) attenuated oxidative stress by modulating the AGEs-RAGE axis.

Cited by 4 publications

References 68 publications

Effect of advanced glycation end-products in a wide range of medical problems including COVID-19

Effect of advanced glycation end-products in a wide range of medical problems including COVID-19

Quality differences in sea buckthorn (Hippophaë rhamnoides L.) berries of major varieties in China based on key components and antioxidant activity

Research progress of sea buckthorn (Hippophae rhamnoides L.) in prevention and treatment of cardiovascular disease

Contact Info

Product

Resources

About