<i>Histamine H4 receptor</i> gene polymorphisms: a potential predictor of oral H1 antihistamine efficacy for allergic rhinitis

Gu, Jian; Mao, Xiaohui; Yang, Xizhi; Ao, Huafei; Zhang, Zhe; Li, You

doi:10.1002/alr.21870

Cited by 14 publications

(9 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hence, HRH4 polymorphisms may be a linker between inflammatory disorders and pathophysiology of MD. Indeed, a few studies have reported that HRH4 polymorphisms are involved in multiple disorders, such as allergic rhinitis [13], ankylosing spondylitis [19], atopic dermatitis [20], asthma [21]. These studies reported the involvement of multiple HRH4 polymorphisms in these disorders.…”

Section: Discussionmentioning

confidence: 99%

“…To test this hypothesis, a group of patients was enrolled with a diagnosis of definite MD based on the American Academy of Otolaryngology-Head and Neck Surgery (AAO-HNS) Committee on Hearing and Equilibrium guidelines [11] and a control group of patients without any vestibular disease. Based on previous reported that HRH4 polymorphisms are involved in allergy, inflammation, and immune reaction [12], one SNP rs77485247 was selected, which has been shown to be associated with the risk of allergic rhinitis [13], a nasal allergy condition that is associated with high prevalence of inner-ear symptoms, including MD [14]. We conducted an exploratory investigation of the correlations of rs77485247 with the symptoms of vertigo and proinflammatory cytokines levels in MD patients.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease

et al. 2019

View full text Add to dashboard Cite

Background The immune system is likely involved in the pathophysiology of Meniere’s disease (MD). However, its role of patients with MD has not been well studied. Given that histamine H4 receptors are highly expressed in immune system, we tested the hypothesis that histamine H4 receptor gene polymorphisms are a potential contributor to the risk of MD. Methods A group of patients was enrolled with a diagnosis of definite MD based on the American Academy of Otolaryngology-Head and Neck Surgery Committee on Hearing and Equilibrium guidelines and a control group of patients without any vestibular disease. We selected one SNP, rs77485247 in HRH4 and conducted an exploratory investigation of its correlations with the symptoms of vertigo and proinflammatory cytokines levels in MD patients. Results HRH4 rs77485247 polymorphism may be associated with the risk of MD. Furthermore, basal levels of proinflammatory cytokines, such as IL-1β and TNF-α, in PBMCs are increased in patients with MD compared to control patients. This increased basal level of proinflammatory cytokines is prominent in MD patients with the A allele. Conclusions These suggested that HRH4 rs77485247 polymorphism may be an important mediator in regulating proinflammatory cytokines, which are involved in the pathogenesis of MD.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease

et al. 2019

View full text Add to dashboard Cite

show abstract

“…Although, the findings of this study should be confirmed in a larger cohort of subjects. Gu et al (2017) identified that polymorphisms rs77485247 (TA+AA) and rs77041280 (TA+TT) within the histamine receptor 4 (HRH4) gene that were associated with reduced efficacy of oral H1 antihistamines and increased risk of adverse reactions in a cohort of AR patients. Given the HRH4 receptor is involved in the chemotaxis of mast cells and eosinophils, polymorphisms to this gene may be associated with worsened disease that requires more extensive treatment.…”

Section: The Future Of Pharmacotherapy In Allergic Rhinitismentioning

confidence: 99%

Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents

et al. 2019

View full text Add to dashboard Cite

Allergic rhinitis (AR) is a chronic upper respiratory disease estimated to affect between 10 and 40% of the worldwide population. The mechanisms underlying AR are highly complex and involve multiple immune cells, mediators, and cytokines. As such, the development of a single drug to treat allergic inflammation and/or symptoms is confounded by the complexity of the disease pathophysiology. Complete avoidance of allergens that trigger AR symptoms is not possible and without a cure, the available therapeutic options are typically focused on achieving symptomatic relief. Topical therapies offer many advantages over oral therapies, such as delivering greater concentrations of drugs to the receptor sites at the source of the allergic inflammation and the reduced risk of systemic side effects. This review describes the complex pathophysiology of AR and identifies the mechanism(s) of action of topical treatments including antihistamines, steroids, anticholinergics, decongestants and chromones in relation to AR pathophysiology. Following the literature review a discussion on the future therapeutic strategies for AR treatment is provided.

show abstract

“…3 Single-nucleotide polymorphisms (SNPs) are also implicated in the pathophysiology of AR. [4][5][6][7][8] Transforming growth factor beta (TGF-b) is a cytokine functioning in a large variety of activities including chemotaxis of inflammatory cells, cell proliferation, immune responses, tissue repair, and fibrosis. 9 Three closely related isoforms, TGF-b1, -b2 and -b3, have been identified in mammals.…”

Section: Introductionmentioning

confidence: 99%

Polymorphism –509C/T in TGFB1 Promoter Is Associated With Increased Risk and Severity of Persistent Allergic Rhinitis in a Chinese Population

Zhu

Chen

et al. 2020

Am J Rhinol�Allergy

View full text Add to dashboard Cite

Background Polymorphism –509C/T in the promoter of transforming growth factor beta1 ( TGFB1) gene is implicated in the pathogenesis of asthma. This polymorphism might also act to regulate the development of allergic rhinitis (AR). Objectives To investigate whether –509C/T is associated with AR susceptibility and severity in a Han Chinese population. Methods The study enrolled 263 patients with persistent AR and 249 healthy controls. AR patients were classified as mild or moderate/severe AR groups according to the Allergic Rhinitis and its Impact on Asthma classification. TGFB1 gene polymorphism –509C/T was genotyped with polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). Serum total Immunoglobulin E (IgE) and specific IgE levels were determined using an ImmunoCAP. Results Significant difference was found in the allele frequency of TGFB1 –509C/T between AR patients and healthy controls ( P = .027) but not in the genotype frequency ( P =.051). However, the genotype frequency of TGFB1 –509C/T showed significant difference between the mild AR group, the moderate/severe AR group, and the control group ( P = .012); between the moderate/severe AR group and the control group ( P =.036); between the mild AR group and the moderate/severe AR group ( P = .038); but not between the mild AR group and the control group ( P =.075). Conclusion TGFB1 promoter polymorphism –509C/T may be associated with the susceptibility and the severity of persistent AR of Han Chinese, but the functional relationship still needs clarification.

show abstract

Histamine H4 receptor gene polymorphisms: a potential predictor of oral H1 antihistamine efficacy for allergic rhinitis

Abstract: Our findings provide evidence that HRH4 rs77485247 and rs77041280 polymorphisms may be associated with the risk of AR and the efficacy of H1 antihistamines for the treatment of AR patients.

Cited by 14 publications

References 26 publications

Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease

Histamine H4 receptor gene polymorphisms: a potential contributor to Meniere disease

Modulation of Allergic Inflammation in the Nasal Mucosa of Allergic Rhinitis Sufferers With Topical Pharmaceutical Agents

Polymorphism –509C/T in TGFB1 Promoter Is Associated With Increased Risk and Severity of Persistent Allergic Rhinitis in a Chinese Population

Contact Info

Product

Resources

About