<i>Histoplasma capsulatum</i> Caused a Localized Tongue Ulcer in a Non-HIV Patient—A Case From Nonendemic Country

Sigera, Liyanage Shamithra Madhumali; Gunawardane, Sumith; Malkanthi, Matharage Ariyalatha; Jayasinghe, Ruwan Duminda; Sitheeque, Mohaideen; Tilakaratne, Wanninayake Mudiyanselage; Jayasekera, Primali Iresha

doi:10.1177/0145561319844246

Cited by 4 publications

(3 citation statements)

References 11 publications

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“…3 So far, five indigenous cases of histoplasmosis have been reported in Sri Lanka. [2][3][4][5][6][7] Four of these patients presented with oral ulcers and the other presented with features of disseminated histoplasmosis with hepatosplenomegaly, fever and generalized lymphadenopathy. One was treated for non-Hodgkin's lymphoma and had previously been employed in Saudi Arabia 3 , while another was an elderly local.…”

Section: Discussionmentioning

confidence: 99%

“…One was treated for non-Hodgkin's lymphoma and had previously been employed in Saudi Arabia 3 , while another was an elderly local. 5 The third was a young, previously well female of European origin. 6 The fourth was a 53-year-old farmer from Batticaloa, who had an accidental injury to the same area in the oral cavity two years prior caused 'by the stick used to drive the buffaloes while ploughing the fields'.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Histoplasmosis in Sri Lanka - a masquerader in a strange land: A Case Report

Jayawardena

Siriwardane²,

Jayasooriya

et al. 2019

Sri Lankan J Infec Dis

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Histoplasmosis in Sri Lanka - a masquerader in a strange land: A Case Report

Jayawardena

Siriwardane²,

Jayasooriya

et al. 2019

Sri Lankan J Infec Dis

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“…The most frequently observed comorbidity among the patients was diabetes mellitus (Vidanagama et al 2010, Jayawardena et al 2019, Jayathilake et al 2020. In addition, one patient presented with non-Hodgkin lymphoma (Karunanayaka et al 2009) and another with Chronic Obstructive Pulmonary Disease (COPD) (Sigera et al 2020). Six of the patients were investigated for HIV status, all were negative.…”

Section: Evaluation For Immunodeficiencymentioning

confidence: 99%

Histoplasmosis in Sri Lanka – barely recognized, yet present

Sigera¹,

Jayasekera²,

Denning³

2023

MycoAsia

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Histoplasmosis has been reported in Sri Lanka for decades; however, clinical recognition and diagnosis of the disease are rare. We conducted a comprehensive search of English-language medical literature from 1969 to February 2022. Our analysis found one population survey of histoplasmin skin sensitivity testing in 1969 (5.7% positive incidence) and ten cases of histoplasmosis across Sri Lanka. The highest number of cases were reported from the Central province, where the positive histoplasmin tests were observed previously. None of the patients were positive for HIV, and both diabetes and betel chewing seem linked with oral histoplasmosis. Out of the reported cases, 50% were diagnosed with disseminated histoplasmosis; asymptomatic, acute pulmonary, and chronic pulmonary histoplasmosis were not observed. The clinical presentation varied from oral lesions (the most common presentation), skin lesions, and fever of unknown origin to adrenal crisis. Fungal culture and histopathology were used for diagnosis, with no use of antigen and antibody testing. Amphotericin B and itraconazole were used as treatment options. The rising at-risk population mandates enhancing laboratory diagnostic facilities and increasing the awareness of medical professionals in Sri Lanka on histoplasmosis.

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Histoplasmosis oral como diagnóstico diferencial de cáncer oral. Serie de casos y revisión de la literatura// Oral histoplasmosis as a differential diagnosis of oral cancer. Case series and literature review

Garola,

Romero Pánico,

Marchetti

et al. 2024

Rev Asoc Odontol Argent

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Resumen Objetivo: La histoplasmosis es una infección fúngica sistémica prevalente en la región del Río de la Plata. Puede exhibir manifestaciones orales, cutáneas y/o sistémicas. Las lesiones bucales significan un desafío diagnóstico debido a su semejanza clínica con el carcinoma oral de células escamosas (COCE). El objetivo de este trabajo fue presentar una serie de casos de histoplasmosis oral enfatizando la importancia del diagnóstico diferencial clínico con el COCE. Casos clínicos: Se describen casos de histoplasmosis oral diagnosticados en los últimos 5 años en la Cátedra de Estomatología “A” de la Facultad de Odontología de la Universidad Nacional de Córdoba, Córdoba, Argentina. En forma paralela, se realizó una revisión de la literatura de los últimos 10 años. Los casos corresponden a 9 pacientes, 6 varones y 3 mujeres, cuya edad promedio fue de 58,6 años. 4 pacientes eran VIH positivos. Se planteó la sospecha de COCE en 5 pacientes, cuya presentación clínica intraoral consistía en úlceras o lesiones ulcerovegetantes, mayormente únicas, ubicadas en la encía. La revisión bibliográfica arrojó un resultado de 48 artículos que incluyeron 60 casos de histoplasmosis oral, con una prevalencia mayor en hombres y similitudes clínicas con COCE en el 80% de los casos. La lesión más predominante fue la úlcera en el 85% de los casos, ubicada en lengua, seguido por el paladar. El diagnóstico de histoplasmosis oral es desafiante y requiere un amplio diferencial, ya que se asemeja a múltiples patologías, debiendo ser considerada ante lesiones ulcerativas orales. Un diagnóstico preciso, de manera interdisciplinaria, es esencial para un tratamiento efectivo. Palabras clave: Carcinoma de células escamosas, histoplasmosis, micosis profunda, oral.// Abstract Aim: Histoplasmosis is a systemic fungal infection prevalent in the Río de la Plata region. It could present oral, cutaneous and/or systemic manifestations. Oral lesions represent a diagnostic challenge due to their clinical similarity to oral squamous cell carcinoma (OSCC). The objective of this work is to present a case series of oral histoplasmosis emphasizing the importance of clinical differential diagnosis with OSCC. Clinical cases: Cases of oral histoplasmosis diagnosed in the last 5 years in the Oral Medicine Department “A” of the Facultad de Odontología of the Universidad Nacional de Córdoba, Córdoba, Argentina are discribed. Alongside, a literature review of the last 10 years was carried out. 9 patients are described, 6 men and 3 women, whose average age was 58.6 years. 4 patients were HIV positive. The suspicion of OSCC was raised in 5 patients, whose intraoral clinical presentation consisted of single ulcers or vegetating ulcers, mostly single, located in the gingiva. The literature review included a total of 48 articles with 60 cases of oral histoplasmosis, with a higher prevalence in men and clinical similarities with OSCC in 80% of cases. The most predominant lesion was the ulcer in 85% of the cases, mostly located on the tongue, followed by the palate. The diagnosis of oral histoplasmosis is challenging and requires a wide differential, since it can mimic multiple pathologies, and should be considered in oral ulcerative lesions. An accurate diagnosis, in an interdisciplinary framework, is essential for effective treatment. Key words: Deep mycosis, histoplasmosis, oral, squamous cell carcinoma.

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Histoplasma capsulatum Caused a Localized Tongue Ulcer in a Non-HIV Patient—A Case From Nonendemic Country

Cited by 4 publications

References 11 publications

Histoplasmosis in Sri Lanka - a masquerader in a strange land: A Case Report

Histoplasmosis in Sri Lanka - a masquerader in a strange land: A Case Report

Histoplasmosis in Sri Lanka – barely recognized, yet present

Histoplasmosis oral como diagnóstico diferencial de cáncer oral. Serie de casos y revisión de la literatura// Oral histoplasmosis as a differential diagnosis of oral cancer. Case series and literature review

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