2012
DOI: 10.1111/j.1528-1167.2012.03461.x
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HLA‐B*1502 allele screening: Determination of carbamazepine‐induced cutaneous reactions

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Cited by 4 publications
(4 citation statements)
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“…This association has been extended to included other antiepileptic drugs with similar structures, such as phenytoin, lamotrigine, and oxcarbazepine (45). Although the PPV for HLA-B * 15:02 and CBZ SJS/TEN is much lower than that for HLA-B * 57:01 and ABC HSR (Table 2), screening strategies for the alleles have been initiated in Chinese and other Asian populations where the B75 alleles are most prevalent (46). HLA-A * 31:01 has also been associated with CBZ SJS/TEN in Europeans and Japanese in some but not all studies (11, 47, 48).…”
Section: The Significance Of the T-cell Receptormentioning
confidence: 99%
“…This association has been extended to included other antiepileptic drugs with similar structures, such as phenytoin, lamotrigine, and oxcarbazepine (45). Although the PPV for HLA-B * 15:02 and CBZ SJS/TEN is much lower than that for HLA-B * 57:01 and ABC HSR (Table 2), screening strategies for the alleles have been initiated in Chinese and other Asian populations where the B75 alleles are most prevalent (46). HLA-A * 31:01 has also been associated with CBZ SJS/TEN in Europeans and Japanese in some but not all studies (11, 47, 48).…”
Section: The Significance Of the T-cell Receptormentioning
confidence: 99%
“…Finally, a total of 20 studies involving patients showing cADRs and CBZ-tolerant patients/normal controls fulfilling the inclusion and exclusion criteria were identified [10][11][12][13][14][15][16][18][19][20][21][23][24][25][26][37][38][39][40][41][42] (Fig. After the exclusion of duplicate studies and review of the abstracts, a total of 52 human population based studies were identified that were based on the HLA variants and susceptibility to cADRs.…”
Section: Characteristics Of the Studies Includedmentioning
confidence: 99%
“…Full text of 52 records were reviewed 32 records excluded, due to 20 studies were included in meta-analysis Table 1 Characteristics of studies with respective genotypic and phenotypic data included in meta-analyses exploring the role of reported cases only, studies for which OR could not be computed because of limited number of individuals or incomplete data, a study failing to stratify HLA data on the basis of drug type, and a single report for a particular HLA allele [17,37,[43][44][45][46][47][48][49][50][51][52][53][54][55]. Table 1 lists all the studies included along with respective study design, diagnostic criteria, number and types of CBZ-induced cADRs and HLA variant/s.…”
Section: Characteristics Of the Studies Includedmentioning
confidence: 99%
“…Until recently, three methods were published for the identification of the HLA-B*15 : 02 allele, including one multiplex PCR using 4 pairs of primers [ 4 , 5 ], one loop-mediated isothermal amplification (LAMP) method [ 6 ], and one nested PCR method [ 7 ]. In this study, we presented a new in-house method which we had designed, validated and implemented in our own setting, and compared the characteristics of each test to consider its applicability in medical practice.…”
Section: Introductionmentioning
confidence: 99%