<i>HLA-DQB1*03</i>
            and
            <i>DRB1*07</i>
            Alleles Increase the Risk of Cervical Cancer Among Uighur and Han Women in Xinjiang, China

Hu, Jian; Liang, Wei; Qi, Cui Hua; Wang, Xue Li; Pan, Xiao Lin; Qi, Li Wen; Shen, Xi; Li, Jiang Fen; Xie, Yu; Pang, Li; Liu, Chun Xia; Zhang, Hai Jun; Lin, Tao; Li, Feng

doi:10.2217/fon-2018-0048

Cited by 4 publications

(6 citation statements)

References 28 publications

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“…In turn, HLA DRB1*14, DRB1*16 and DQA1*0301 were more often observed in healthy "no CIN" women. Previous studies have described DRB1*15 association with cervical cancer in various populations [6][7][8][9]17,18]. We have found this allele significantly more often in CIN1 and CIN2+ patients.…”

Section: Discussionsupporting

confidence: 58%

Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia

Plisko,

Žodžika,

Jermakova

et al. 2024

AML

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Background: Persistent human papillomavirus (HPV) infection is a necessary cause for development of cervical precancerous lesions and cervical cancer, however, only a small percentage of women progress to cervical cancer. The local immune response, determined, among other factors, by Human Leucocyte Antigen (HLA) genes, is thought to be significant. Still the results of genome studies are inconsistent and differ between ethnical populations. The aim of the study was to assess an association between HLA-DQA1*; DQB1*; DRB1* allele’s genetic variants between women with cervical precancerous lesions and healthy controls in Latvia.Materials and methods: From January until April 2017 we enrolled 84 consecutive patients referred for colposcopy to Riga East University Hospital (Latvia) due to abnormal cervical cytology results. 57 women who came for a regular check-up and had normal cytology smears were included in the control group. Material from the cervix was taken for subsequent HLA genotyping of 13 DRB1*, 8 DQA1*, and 12 DQB1* alleles. Colposcopy was performed on all participants. In case of visual suspicion for CIN cervical biopsy was done.Results: There were 57 “no CIN” patients, 23 histologically proven CIN 1 and 61 CIN2+ cases in the study population. CIN2+ was more often associated with DQA1*0401 (OR 6.68, 95% CI 1.47-30.29, p=0.014), DRB*15 (OR 2.99, 95% CI 1.22-7.39, p=0.017), DQB1*0401 (OR 2.91, 95%CI 1.11-7.68, p=0.03), DQA1*0103 (OR 2.72, 95% CI 1.02-7.21, p=0.045), DRB1*11 (OR 2.42, 95% CI 1.10-5.33, p=0.029) and DQB1*0301 (OR 1.94, 95% CI 1.12-3.38, p=0.018). Women with “no CIN” more often had DQB1*0501 (OR 0.17, 95% CI 0.04-0.81, p=0.026), DRB1*16 (OR 0.21, 95% CI 0.06-0.78, p=0.019), DQA1*0301 (OR 0.35, 95% CI 0.14-0.87, p=0.024) and DRB1*14 (OR 0.59, 95% CI 0.01-0.46, p=0.007).Conclusions: In the current study we have demonstrated a strong association with risk and protective HLA class II alleles that are determined by the HLA-DRB1*; DQA1*; DQB1*.

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Section: Discussionsupporting

confidence: 58%

Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia

Plisko,

Žodžika,

Jermakova

et al. 2024

AML

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“…Associations of HLA-B*15, HLA-B*15:01, HLA-DRB1*11, HLA-DRB1*11:01, HLA-DRB1*13, HLA-DRB1*13:02, HLA-DRB1*15, HLA-DQB1*06:01, and HLA-DQB1*06:04 were not significant but were replicated with directional concordance of the allelic CC risk (eTable 1 in the Supplement ). 13 , 14 , 16 , 17 , 18 , 19 , 20 , 21 …”

Section: Resultsmentioning

confidence: 99%

“…11 On the other hand, the HLA alleles previously reported to have associations with CC did not reach the significant but were replicated with directional concordance of the allelic CC risk (eTable 1 in the Supplement). 13,14,[16][17][18][19][20][21] When conditioned on HLA-B*52:01, no other variants in the MHC region satisfied the genomewide significance (Figure 1B). This suggested that all the other variants that originally satisfied the At an amino acid level, the most significant association was observed at the amino acid position 171 of the HLA-B molecule (HLA-B p.Tyr171His; OR = 1.47; 95% CI, 1.30-1.66; P = 1.2 × 10 −9 ) (eTable 2 in the Supplement).…”

Section: Association Analysis and Conditioningmentioning

confidence: 96%

“…However, because the genetic structure of the MHC region is highly complex and diverse among populations, 10 , 11 , 12 more detailed and population-specific analysis is required for fine mapping of the CC causal variant embedded within MHC. Because the previous candidate gene-based reports have mainly focused on the class II human leukocyte antigen (HLA) alleles, 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 comprehensive fine-mapping analyses assessing both class I and II HLA alleles, nonclassical HLA alleles, and amino acid variations are warranted. 21 Recently, a new computational method has been developed for detailed fine-mapping analysis of the MHC region, which is called the HLA imputation.…”

Section: Introductionmentioning

confidence: 99%

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Fine Mapping of the Major Histocompatibility Complex Region and Association of the HLA-B*52:01 Allele With Cervical Cancer in Japanese Women

et al. 2020

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Key Points Question Which gene in the major histocompatibility complex region is associated with cervical cancer? Findings This genetic association study of 704 women with cervical cancer and 39 829 women without gynecologic disease used fine mapping of the major histocompatibility complex region by human leukocyte antigen imputation and found that HLA-B*52:01 was associated with cervical cancer in the Japanese population. Meaning These findings suggest that immune responses against human papillomaviruses are mediated by class I human leukocyte antigen molecules, which are associated with susceptibility to cervical cancer.

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“…Worldwide in non-LS populations, different HLA alleles have been reported to be associated with various cancers, such as cervical [ 26 , 42 , 43 ], leukemia [ 44 ], hepatocellular [ 45 ], lung squamous cell [ 46 ], cutaneous T cell lymphoma [ 47 ], and gastric carcinomas [ 48 , 49 ]. For instance, the HLA-DP gene polymorphisms ( HLA-DPB1*03:01 and HLA-DPB1*13:01 ) have been significantly associated with an increased risk of cervical cancer in Chinese populations [ 50 , 51 , 52 , 53 ].…”

Section: Discussionmentioning

confidence: 99%

Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome

Ndou,

Chambuso,

Valley-Omar

et al. 2024

JPM

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Lynch syndrome (LS) is an inherited cancer predisposition disorder associated with an elevated risk of developing various solid cancers, but mostly colorectal cancer (CRC). Despite having the same germline pathogenic variant (PV) in one of the mis-match repair genes or the EPCAM gene, Lynch syndrome variant heterozygotes (LSVH) exhibit a remarkable phenotypic variability in the risk of developing cancer. The role of human leukocyte antigen (HLA) in modifying cancer development risk prompted our hypothesis into whether HLA variations act as potential genetic modifiers influencing the age at cancer diagnosis in LSVH. To investigate this, we studied a unique cohort of 426 LSVH carrying the same germline PV in the hMLH1 gene (MLH1:c.1528C > T) in South Africa. We intuitively selected 100 LSVH with the greatest diversity in age at cancer diagnosis (n = 80) and the oldest cancer unaffected LSVH (n = 20) for a high-throughput HLA genotyping of 11 HLA class I and class II loci using the shotgun next-generation sequencing (NGS) technique on the Illumina MiSeq platform. Statistical analyses employed Kaplan–Meier survival analyses with log-rank tests, and Cox proportional hazards using binned HLA data to minimize type I error. Significant associations were observed between young age at cancer diagnosis and HLA-DPB1*04:02 (mean age: 37 y (25–50); hazard ratio (HR) = 3.37; corrected p-value (q) = 0.043) as well as HLA-DPB1 binned alleles (including HLA-DPB1*09:01, HLA-DPB1*10:01, HLA-DPB1*106:01, HLA-DPB1*18:01, HLA-DPB1*20:01, HLA-DPB1*26:01, HLA-DPB1*28:01, HLA-DPB1*296:01, and HLA-DPB1*55:01) (mean age: 37 y (17–63); HR = 2.30, q = 0.045). The involvement of HLA-DPB1 alleles in the age at cancer diagnosis may highlight the potential role of HLA class II in the immune response against cancer development in LSVH. When validated in a larger cohort, these high-risk HLA-DPB1 alleles could be factored into cancer risk prediction models for personalized cancer screening in LSVH.

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HLA-DQB103* and DRB107* Alleles Increase the Risk of Cervical Cancer Among Uighur and Han Women in Xinjiang, China

Abstract: This study suggests that HLA-DQB103 and DRB107 alleles may influence the immune response to HPV16 infection and increase the risk of CSCC among the Uighurs and Hans in China.

Cited by 4 publications

References 28 publications

Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia

Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia

Fine Mapping of the Major Histocompatibility Complex Region and Association of the HLA-B*52:01 Allele With Cervical Cancer in Japanese Women

Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome

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HLA-DQB1*03 and DRB1*07 Alleles Increase the Risk of Cervical Cancer Among Uighur and Han Women in Xinjiang, China

Abstract: This study suggests that HLA-DQB1*03 and DRB1*07 alleles may influence the immune response to HPV16 infection and increase the risk of CSCC among the Uighurs and Hans in China.

Cited by 4 publications

References 28 publications

Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia

Human Leucocyte Antigen Class II Risk and Protective Alleles in Women with Cervical Intraepithelial Neoplasia

Fine Mapping of the Major Histocompatibility Complex Region and Association of the HLA-B*52:01 Allele With Cervical Cancer in Japanese Women

Human Leukocyte Antigen-Allelic Variations May Influence the Age at Cancer Diagnosis in Lynch Syndrome

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Product

Resources

About

HLA-DQB103* and DRB107* Alleles Increase the Risk of Cervical Cancer Among Uighur and Han Women in Xinjiang, China

Abstract: This study suggests that HLA-DQB103 and DRB107 alleles may influence the immune response to HPV16 infection and increase the risk of CSCC among the Uighurs and Hans in China.