<i>HMGA2</i> rs968697 T &gt; C polymorphism is associated with the risk of colorectal cancer

Gao, Xueren; Wang, Xiaoting

doi:10.1080/15257770.2021.1952596

Cited by 9 publications

(9 citation statements)

References 18 publications

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“…GC patients carrying the rs968697 CT and Recent studies have shown that the HMGA2 rs968697 genetic polymorphism could reduce susceptibility to digestive tumors, including hepatoblastoma and colorectal cancer. 14,15 However, the findings in other malignancies were inconsistent and needed to be clarified by meta-analysis. The current meta-analysis showed that the rs968697 genetic polymorphism was linked to malignancy susceptibility in the Chinese population.…”

Section: Discussionmentioning

confidence: 99%

“…The primer sequences are displayed in Table S1. 14 The mRNA expression levels were calculated using the 2 ÀΔΔCt approach. GAPDH expression levels were used as internal controls.…”

Section: Genotype-tissue Expression Analysismentioning

confidence: 99%

“…It is worth noting that previous case-control studies have indicated that the rs968697 T>C genetic polymorphism located in the HMGA2 gene promoter region is associated with susceptibility to colorectal cancer and hepatoblastoma. 14,15 However, no study has reported the association of the rs968697 genetic polymorphism with GC susceptibility. Additionally, it has also been suggested that the rs968697 genetic polymorphism is not linked to malignancy susceptibility.…”

Section: Introductionmentioning

confidence: 99%

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The relationship between rs968697 genetic polymorphism and gastric cancer susceptibility, TNM stage and survival prognosis

Hu,

Wang

2023

Eur J Inflamm

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Background HMGA2 can promote the development of multiple malignancies. This study aimed to determine whether a putative functional genetic polymorphism (rs968697 T>C) in the HMGA2 gene promoter region was associated with malignancy susceptibility in the Chinese population. Methods The rs968697 genetic polymorphism was genotyped using the SNaPshot method in the case-control study. The odds ratios and 95% confidence intervals were calculated using a logistic regression model. STATA software was used to conduct the meta-analysis. Results The rs968697 genetic polymorphism was associated not only with susceptibility to malignant tumors [CC versus TT: OR = 0.45, 95%CI = 0.28–0.73, p = .001; CC versus (CT + TT): OR = 0.47, 95%CI = 0.29–0.75, p = .003] including gastric cancer (GC), but also with TNM stage and survival prognosis of GC patients. Genotype-tissue expression analysis, luciferase assay and bioinformatics analysis revealed that the rs968697 genetic polymorphism might affect the binding of transcription factors, especially POLR2A, which in turn regulate the expression of HMGA2. Conclusions The current research suggests that the rs968697 genetic polymorphism may be used as a biomarker for malignancy susceptibility and GC prognosis in the Chinese population.

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Section: Discussionmentioning

confidence: 99%

“…The primer sequences are displayed in Table S1. 14 The mRNA expression levels were calculated using the 2 ÀΔΔCt approach. GAPDH expression levels were used as internal controls.…”

Section: Genotype-tissue Expression Analysismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The relationship between rs968697 genetic polymorphism and gastric cancer susceptibility, TNM stage and survival prognosis

Hu,

Wang

2023

Eur J Inflamm

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“…Te occurrence and development of CRC is a complicated and multidimensional process, and epidemiological studies have found multiple risk factors associated with the occurrence of CRC, including various unhealthy diets and lifestyles [2]. In addition, previous genomics studies have revealed that single nucleotide polymorphisms (SNPs) in several CRC-related genes are linked to the risk and progression of CRC [3][4][5][6][7][8]. For instance, the interleukins-17A (IL-17A) rs2275913 G > A polymorphism was associated with the occurrence and severity of CRC in the Bulgarian population [6].…”

Section: Introductionmentioning

confidence: 99%

TP73-AS1 rs3737589 Polymorphism is Associated With the Clinical Stage of Colorectal Cancer

Gao

Zhang

Gao

2023

Evidence-Based Complementary and Alternative Medicine

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Objective. TP73-AS1 can promote the occurrence and development of a variety of tumors, including colorectal cancer (CRC). The current study aimed to investigate the association between a potentially functional genetic polymorphism (rs3737589 T > C) on the TP73-AS1 gene and the susceptibility and clinical stage of CRC in a Chinese Han population. Methods. The polymorphic genotyping was performed by the SNaPshot method. The real-time quantitative PCR method and the luciferase assay were used separately to explore genotype-tissue expression and the function of the genetic polymorphism. Results. A total of 576 CRC patients and 896 healthy controls were included in the current study. The rs3737589 polymorphism was not associated with CRC susceptibility but was associated with the CRC stage (CC vs. TT: OR = 0.25, 95% CI = 0.12 – 0.54, P = 0.0003 ; C vs. T: OR = 0.69, 95% CI = 0.53–0.89, P = 0.006 ; and CC vs. (TC + TT): OR = 0.26, 95% CI = 0.12–0.56, P = 0.0004 ). CRC patients carrying the rs3737589 CC genotype or C allele were less likely to have stage III/IV tumors than those carrying the rs3737589 TT genotype or T allele. The expression of TP73-AS1 was lower in CRC tissues with the rs3737589 CC genotype compared to those with the TT genotype. Bioinformatics analysis and the luciferase assay revealed that the C allele could promote the binding of miR-3166 and miR-4771 to TP73-AS1. Conclusion. The TP73-AS1 gene rs3737589 polymorphism affecting miRNAs binding is associated with the CRC stage and may serve as a biomarker for predicting CRC progression.

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“…Cancer is one of the most serious public health issues in the world, with approximately 18.1 million new cancer diagnoses and 9.6 million cancer deaths in 2018 ( 1 ). Although the precise processes of cancer development and progression are still largely unclear, a growing body of research suggests that genetic predisposition has a substantial influence on the likelihood of individual cancer development ( 2 , 3 ).…”

Section: Introductionmentioning

confidence: 99%

The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility

Gao¹,

Li²,

Zhang

et al. 2021

Front. Oncol.

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Although the association of MEG3 gene rs7158663 polymorphism with cancer susceptibility has been investigated, the findings are inconsistent. The aim of this study was to analyze the association between the rs7158663 polymorphism and cancer susceptibility through a case-control study and meta-analysis. In a case-control study with 430 colorectal cancer (CRC) cases and 445 healthy controls, the rs7158663 polymorphism was genotyped by direct sequencing. STATA software was used to calculate the pooled odds ratio and 95% confidence interval in a meta-analysis including 4,649 cancer cases and 5,590 controls. Both the case-control study and meta-analysis showed that the rs7158663 polymorphism was associated with increased susceptibility to CRC. Individuals carrying the AA or GA genotype were more likely to develop CRC than those carrying the rs7158663 GG genotype. Interestingly, MEG3 expression was significantly lower in colorectal tissues of the AA or GA genotype compared to those of the rs7158663 GG genotype. In addition, the meta-analysis suggested that the rs7158663 polymorphism was also associated with increased susceptibility to breast cancer and gastric cancer. Bioinformatics analysis showed that the rs7158663 A allele contributed to the binding of hsa-miR-4307 and hsa-miR-1265 to MEG3. In conclusion, the current findings suggest that the MEG3 gene rs7158663 polymorphism may serve as a genetic marker for predicting the risk of cancers, such as breast cancer, gastric cancer and CRC. However, the sample size of the current study is still insufficient, especially in the subgroup analysis. Therefore large and well-designed studies are needed to validate our findings.

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HMGA2 rs968697 T > C polymorphism is associated with the risk of colorectal cancer

Cited by 9 publications

References 18 publications

The relationship between rs968697 genetic polymorphism and gastric cancer susceptibility, TNM stage and survival prognosis

The relationship between rs968697 genetic polymorphism and gastric cancer susceptibility, TNM stage and survival prognosis

TP73-AS1 rs3737589 Polymorphism is Associated With the Clinical Stage of Colorectal Cancer

The Association of MEG3 Gene rs7158663 Polymorphism With Cancer Susceptibility

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