Hormographiella aspergillatakeratomycosis in a dog

Abstract

A 4-year-old, female, Border Collie was presented to the University of Bern Veterinary Teaching Hospital, because of a corneal lesion of 10 days duration. The axial cornea presented a whitish fluorescein-positive plaque with irregular margins. A diagnosis of keratomycosis was made based on cytology. Medical therapy with local broad-spectrum antibiotic and fluconazole was instituted. After 1 week of treatment, the improvement was deemed unsatisfactory. Therefore, a lamellar keratectomy and conjunctival pedicle flap were performed. After surgery, the cornea healed uneventfully. Histology confirmed the diagnosis of keratomycosis. The fungus could not be grown in culture and a precise etiological diagnosis could only be obtained with genetic identification of the fungus. A PCR technique was used to amplify the fungal genome from the cornea. Hormographiella aspergillata , the asexual reproductive form of the basidiomycete Coprinopsis cinerea , was identified. As advised in human medicine, we encourage the use of this molecular technique to obtain an early species diagnosis, allowing targeted medical therapy.

Splenitis in 33 Dogs

“…15 In addition, identification of fungi was performed on an approximately 330-bp fragment of the ITS region 2 using primers ITS3 and ITS4. 35 For protozoa, the analysis was performed to identify L. infantum and Hepatozoon spp. The target sequence for Leishmania was LT1 of the conserved region of the circular kinetoplast DNA; the primers used were RV1 (forward, 5 0 -CTTTTCTGGTCCCGCGGGTAGG-3 0 ) and RV2 (reverse, 5 0 -CCACCTGGCCTATTTTACACCA-3 0 ), with a reported sensitivity of 100% in detecting Leishmania infections.…”

Fungal Keratitis Secondary to Trametes betulina: A Case Report and Review of Literature

“…The most commonly involved genera are Candida, Aspergillus, and Fusarium; however, the diversity of fungal species found to cause keratitis continues to grow [5]. A few recent reports reference basidiomycetes as ocular pathogens (including Schizophyllum commune and Hormographiella aspergillata), but no reports of human infection by Lenzites betulinus/Trametes betulina were found on literature review [5,14,15].…”

Acremoniumkeratomycosis in a cat

“…Outcomes are largely dependent on treatment choice and efficacy, a decision often based upon information from reports involving the companion animal species most commonly affected, the horse 17 . In contrast to the horse, keratomycosis is reported uncommonly in the dog and rarely in the cat 3–5,18–24 . To the authors’ knowledge, this is the first report to document Acremonium keratomycosis in a cat.…”