‘<i>Hypericum brasiliense</i>: bactericidal and antibiofilm activity against <i>Staphylococcus aureus in vitro’</i>

Pereira, Renata Freire Alves; André, Lialyz Soares Pereira; Pinheiro, Felipe Ramos; Scaffo, J.; Corrêa, Arthur Luiz; Ribeiro, Tainara Aparecida Nunes; Sachs, Daniela; Rocha, Leandro; Aguiar-Alves, Fábio

doi:10.1080/14786419.2021.1915306

Cited by 2 publications

(3 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Additionally, as expected, Hypericum extracts were quite potent against S. aureus , with MICs on a multidrug-resistant (MDR) strain of 4 mg/L for H. brasiliense [ 87 ]. In some cases though, the MeOH extract from H. perforatum could give MICs against S. aureus and staphylococci isolated from cow mastitis as high as 813 mg/L [ 88 ].…”

Section: Discussionmentioning

confidence: 71%

“…Again, an ethanol extract, but from H. perforatum , had a MBIC 50 for the MRSA biofilm of 128 mg/L, lower than the inhibitory concentration for planktonic growth [ 94 ]. An extract from H. brasiliense failed to show MBIC or MBIC 50 values equal or lower than its very low MIC value of 4 mg/L on the MDR S. aureus strain for a mature biofilm grown for 24 h, only for a forming and six-hour-old biofilm [ 87 ]. A polyurethane material combined with H. perforatum extract inhibited the formation of S. aureus biofilm [ 95 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Ilieva

Marinov

Trayanov

et al. 2023

Life

View full text Add to dashboard Cite

Microbial infections are by no means a health problem from a past era due to the increasing antimicrobial resistance of infectious strains. Medicine is in constant need of new drugs and, recently, plant products have had a deserved renaissance and garnered scientific recognition. The aim of this work was to assess the antimicrobial activity of ten active ingredients from four Hypericum species growing in Bulgaria, as well as to obtain preliminary data on the phytochemical composition of the most promising samples. Extracts and fractions from H. rochelii Griseb. ex Schenk, H. hirsutum L., H. barbatum Jacq. and H. rumeliacum Boiss. obtained with conventional or supercritical CO2 extraction were tested on a panel of pathogenic microorganisms using broth microdilution, agar plates, dehydrogenase activity and biofilm assays. The panel of samples showed from weak to extraordinary antibacterial effects. Three of them (from H. rochelii and H. hirsutum) had minimum inhibitory concentrations as low as 0.625–78 mg/L and minimum bactericidal concentrations of 19.5–625 mg/L against Staphylococcus aureus and other Gram-positive bacteria. These values placed these samples among the best antibacterial extracts from the Hypericum genus. Some of the agents also demonstrated very high antibiofilm activity against methicillin-resistant S. aureus. Ultra-high-performance liquid chromatography–high-resolution mass spectrometry revealed the three most potent samples as rich sources of biologically active phloroglucinols. They were shown to be good drug or nutraceutical candidates, presumably without some of the side effects of conventional antibiotics.

show abstract

Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Ilieva

Marinov

Trayanov

et al. 2023

Life

View full text Add to dashboard Cite

show abstract

“…Interestingly , the extracts outperformed common antibiotics (streptomycin sulfate and nystatin) concerning their antimicrobial effects. Pereira et all., found that Hypericum brasiliense extract inhibited and eradicated S. aureus HU25 planktonic cells and their biofilm formation [ 40 ]. The anti-biofilm activity of H. scabrum could be related to the higher proportion of polyphenols and flavonoids including catechin, quercetin and vanillic acid in the plant, which have been found to possess anti-biofilm activities [ 41 , 42 ].…”

Section: Discussionmentioning

confidence: 99%

In vitro antimicrobial and antibiofilm screening of eighteen Iranian medicinal plants

Hamidi,

Toosi,

Javadi

et al. 2024

BMC Complement Med Ther

View full text Add to dashboard Cite

Background Natural products are one of the best candidates for controlling drug-resistant pathogens, the advantages of which include low production costs and low side effects. In this study, as potential antimicrobials, the anti-bacterial and antibiofilm activities of several Iranian native medicinal plants were screened. Methods The antibacterial/antifungal and anti-biofilm activities of 18 medicinal plants including Reseda lutea L., Nepeta sintenisii Bunge., Stachys turcomanica Trautv., Stachys lavandulifolia Vahl, Diarthron antoninae (Pobed.) Kit Tan., Ziziphora clinopodioides Lam., Euphorbia kopetdaghi Prokh, Euphorbia serpens Kunth., Hymenocrater calycinus Benth., Scutellaria pinnatifida A.Ham., Viola tricolor L., Hypericum helianthemoides (Spach) Boiss., Hypericum scabrum L., Convolvulus lineatus L., Scabiosa rotata M.Bieb Greuter & Burdet, Delphinium semibarbatum Bien. Ex Boiss., Glycyrrhiza triphylla Fisch. & C.A.Mey., and Ziziphus jujuba Mill., against two Gram-positive bacteria, Staphylococcus aureus, Bacillus cereus, as well as two Gram-negative bacteria, Pseudomonas aeruginosa, Escherichia coli; and Candida albicans as a fungal strain, were evaluated. The minimum inhibitory concentration (MIC) and minimum bactericidal/fungicidal concentration (MBC/MFC) values of the extracts against tested microorganisms were reported and we investigated their effect on the biofilm inhibition of Pseudomonas aeruginosa PAO1, Staphylococcus epidermis, Staphylococcus aureus and Streptococcus mutans. In addition, the effect of the extracts on the eradication of the biofilms of these bacteria was evaluated. Results In this study, H. scabrum was found to exhibit potentially significant activity against Gram-positive bacteria with the MIC range of 6.25–25 µg/mL. This extract also showed a significant effect on inhibiting the biofilm of S. aureus, S. mutans, and S. epidermidis and eradicating the biofilm of S. epidermidis DSMZ 3270. In addition, Hymenocrater calycinus root extract had moderate antibacterial activity against B. cereus with the MIC and MBC 62.5 µg/mL, respectively. Conclusions The results of this study showed that the root extracts of two plants, Hypericum scabrum and Hymenocrater calycinus, had antimicrobial and anti-biofilm effects. Based on the observed anti-biofilm effects, these two plants may be considered in future studies to find responsible antimicrobial compounds.

show abstract

‘Hypericum brasiliense: bactericidal and antibiofilm activity against Staphylococcus aureus in vitro’

Cited by 2 publications

References 16 publications

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

Outstanding Antibacterial Activity of Hypericum rochelii—Comparison of the Antimicrobial Effects of Extracts and Fractions from Four Hypericum Species Growing in Bulgaria with a Focus on Prenylated Phloroglucinols

In vitro antimicrobial and antibiofilm screening of eighteen Iranian medicinal plants

Contact Info

Product

Resources

About