<i>Hypericum silenoides</i> Juss. and <i>Hypericum philonotis</i> Cham. &amp; Schlecht. extracts: in-vivo hypolipidaemic and weight-reducing effects in obese rats

Cruz, Leticia García-de la; Galvan-Goiz, Yareth; Caballero-Caballero, Sergio; Zamudio, Sergio; Alfaro, A. Reyes; Navarrete, Andrés

doi:10.1111/jphp.12015

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Cited by 11 publications

References 31 publications

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Nutraceuticals in Obesity and Metabolic Disorders

Cope

2019

Nutraceuticals in Veterinary Medicine

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Nutraceuticals in Obesity and Metabolic Disorders

Cope

2019

Nutraceuticals in Veterinary Medicine

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Lipase inhibitory activity of constituents of Physalis glutinosa and Physalis latiphysa

Maldonado,

Mineros,

Torres

et al. 2023

Med Chem Res

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The new labdane-type diterpenoid, physaglutinic acid (1), was isolated from the hexane extract of Physalis glutinosa. This compound is the first succinyl labdane isolated from a Physalis species. The known constituents of this plant were identified as the labdanes 12-O-acetylphysacoztomatin (3), physacoztomatin (4) and 12-epi-nicandrodiol (6). The flavonol retusin (8) was also isolated from this species. The investigation of the acetone extract of Physalis latiphysa resulted in the isolation of the known (+)- (Z)-labda-8(17),13-diene-15,16-diol (9), labdenediol (11), the epimeric mixture of physanicantriol (12) and 14 epi-physanicantriol (13), together with the sucrose esters, nicandroses B (15) and D (16). Also, a large amount of the flavonol glycoside rutin (17) was obtained from the methanol extract. The activity of eight of the isolated compounds and three of their derivatives as lipase inhibitors was determined. The mode of binding of active compounds 4, 10 and 16 was explored using molecular docking on the binding pocket of pancreatic lipase (PDB ID 1LPB).

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Nutraceuticals for weight loss

Cope¹

2021

Nutraceuticals

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Hypericum silenoides Juss. and Hypericum philonotis Cham. & Schlecht. extracts: in-vivo hypolipidaemic and weight-reducing effects in obese rats

Abstract: Some H. silenoides and H. philonotis extracts showed a significant anti-obesity activity in cafeteria-diet-fed rats. This research provides the first scientific support for the use of the Hypericum genus for weight reduction in Mexican folk medicine.

Cited by 11 publications

References 31 publications

Nutraceuticals in Obesity and Metabolic Disorders

Nutraceuticals in Obesity and Metabolic Disorders

Lipase inhibitory activity of constituents of Physalis glutinosa and Physalis latiphysa

Nutraceuticals for weight loss

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