2015
DOI: 10.3389/fimmu.2015.00020
|View full text |Cite
|
Sign up to set email alerts
|

γδ T Lymphocytes in the Diagnosis of Human T Cell Receptor Immunodeficiencies

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1
1

Citation Types

1
37
0

Year Published

2017
2017
2024
2024

Publication Types

Select...
8
1

Relationship

0
9

Authors

Journals

citations
Cited by 51 publications
(38 citation statements)
references
References 35 publications
1
37
0
Order By: Relevance
“…Tgd17 cells can be positive for CD4 and IL-17A, so they may also be responsible for inducing syndecan-2 expression. However, about 70% of gdT cells exist as CD4 2 CD8 2 cells, and they only account for about 1-10% of blood cells (42)(43)(44). The markers consistently used to identify gdT cells are Vg4 high , CCR6 high , and CD27 low , which we did not use to determine specific immune cells in our experiments.…”
Section: Discussionmentioning
confidence: 92%
See 1 more Smart Citation
“…Tgd17 cells can be positive for CD4 and IL-17A, so they may also be responsible for inducing syndecan-2 expression. However, about 70% of gdT cells exist as CD4 2 CD8 2 cells, and they only account for about 1-10% of blood cells (42)(43)(44). The markers consistently used to identify gdT cells are Vg4 high , CCR6 high , and CD27 low , which we did not use to determine specific immune cells in our experiments.…”
Section: Discussionmentioning
confidence: 92%
“…Acute colitis models were produced in mice by oral administration of 1.5 or 3% DSS [35][36][37][38][39][40][41][42][43][44][45][46][47][48][49][50] in the drinking water for 4 d followed by 6 d on tap water. For acetylsalicylic acid (ASA) treatment, mice were divided into 3 groups, which were treated as follows: 3% DSS treatment plus daily injections of 0.5 mg, i.p.…”
Section: The Acute Dss-induced Murine Model Of Colitismentioning
confidence: 99%
“…In addition, interestingly, there are six clusters of CD4-CD8-T cells, where four are γδ T cells. These have been noted as a characteristic of reaction to viral infections [35][36][37][38][39]. There are twelve clusters representing effector memory cells and nine regulatory T cells that are CD4+Foxp3+.…”
Section: Differential Cluster Proportions Between Subjectsmentioning
confidence: 99%
“…TCR is a heterodimer formed of either α and β (in over 90% of T cells) or γ and δ chains (in 1-10% of T cells) ( Figure 1a) [5,6]. TCR lacks its own signalling domains, therefore it associates with CD3 complex that consists of two heterodimers CD3γ/CD3ε and CD3δ/CD3ε and a single homodimer CD3ζ/CD3ζ (also termed CD247).…”
Section: Tcr-structure and Signallingmentioning
confidence: 99%