<i>IL‐7R</i> gene polymorphisms among patients with rheumatoid arthritis: A case–control study

Bai, Mei; He, Xue; He, Yongjun; Yuan, Dongya; Jin, Tianbo; Wang, Li

doi:10.1002/mgg3.738

Cited by 8 publications

(3 citation statements)

References 32 publications

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“…IL-7R/JAK signaling mediated by IL-7 and IL-7R is necessary for the development and homeostasis of normal T-cells [40] . According to an epidemiological analysis, rs6451231 and rs969129 in IL-7R are associated with an elevated risk of RA, indicating that such IL-7R mutations could potentially serve as susceptibility loci for RA in the Han population [41] . However, the mechanism of studying IL7R in RA has not yet been elucidated.…”

Section: Discussionmentioning

confidence: 99%

Hub gene mining and immune microenvironment analysis of autophagy in rheumatoid arthritis

Wang,

You,

Liang

et al. 2024

Preprint

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Background Autophagy is closely associated with the pathogenesis and progression of rheumatoid arthritis (RA). However, the mechanisms of RA and autophagy are currently unclear. Therefore, it is essential to identify appropriate biomarkers for early diagnosis. Methods Autophagy-related genes (ARGs) were intersected with differentially expressed genes (DEGs). The resulting intersection was subjected to GO, KEGG, and GSEA analysis, and the protein-protein interaction (PPI) network was drawn to further analyze hub genes. The performance evaluation of the hub gene was identified to explore its potential value. Based on this, different correlations with immune cell infiltration were analyzed. Results Five relatively stable hub genes–CXCL10, CXCL9, GZMB, IL7R, and CD2–were identified. Expression levels of these genes also differed. Through functional enrichment analysis, we found that they were related to autophagy and natural immune inflammation and that the expression of the hub gene was associated with the expression of the infiltrating immune cell abundance gene. Conclusion In our study, five hub genes were identified, which may help develop therapeutic agents targeting autophagy for the early diagnosis and treatment of patients with RA.

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Section: Discussionmentioning

confidence: 99%

Hub gene mining and immune microenvironment analysis of autophagy in rheumatoid arthritis

Wang,

You,

Liang

et al. 2024

Preprint

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“…In our study, we explored the influence of IL-7R SNPs (rs6451231, rs10213865, rs118137916, rs969129, and rs10053847) on breast cancer susceptibility in Chinese Han population. Bai et al [26] that IL-7R SNPs (rs6451231 and rs969129)…”

Section: Discussionmentioning

confidence: 99%

Correlation between IL‐7R gene variants and breast cancer susceptibility in Chinese Han women

Li¹,

Yue²,

Zuo³

et al. 2020

Preprint

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Introduction IL-7R is involved in the occurrence and development of breast cancer by binding to its ligand IL-7. This study aimed to explore the potential relationships of IL-7R polymorphisms with breast cancer susceptibility in Chinese Han women.Methods Five polymorphisms (rs969129, rs10213865, rs10053847, rs118137916, and rs6451231) of IL-7R genewere genotyped in 553 patients and 550 healthy healthy individuals from the in Chinese Han women using the Agena MassARRAY platform. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated used to evaluate the relationship.Results IL-7R rs10213865, rs969129 and rs6451231 was correlated with an increased the risk of breast cancer in multiple genetic models. Age stratified analysis revealed that rs6451231 was correlated with an increased breast cancer risk at age > 52 years. Additionally, rs10213865 was correlated with tumor site and ER expression, rs969129 was related to tumor size and Ki67 expresses status, and rs6451231was related to tumor size. Haplotype CGAG (rs969129, rs10213865, rs10053847 and rs118137916) were observed to a decrease breast cancer risk.Conclusions IL-7R polymorphism were significantly correlated with an increased breast cancer susceptibility in Chinese Han women.

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“…Several studies involving patients with multiple sclerosis (MS) and primary Sjögren's syndrome (pSS) demonstrate that both IL-7 and IL-7R are overexpressed in the cerebrospinal fluid and labial salivary glands, respectively, with these expression levels correlating to the severity of the disease ( 35 – 37 ). Increased susceptibility to autoimmune diseases such as MS, type 1 diabetes or RA have been linked to several single nucleotide polymorphisms in IL-7R gene loci ( 35 , 38 – 40 ). In the case of MS, haplotypes in IL7R gene have been reported to lead to modulations in levels of soluble IL-7R which has also been upregulated in patients with pSS ( 41 , 42 ).…”

Section: Genetic Variations In Il-7 Axis Play a Role In Both Autoimmumentioning

confidence: 99%

Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer

Marković

Savvides

2020

Front. Immunol.

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Thymic Stromal Lymphopoietin (TSLP) and Interleukin-7 (IL-7) are widely studied cytokines within distinct branches of immunology. On one hand, TSLP is crucially important for mediating type 2 immunity at barrier surfaces and has been linked to widespread allergic and inflammatory diseases of the airways, skin, and gut. On the other hand, IL-7 operates at the foundations of T-cell and innate lymphoid cell (ILC) development and homeostasis and has been associated with cancer. Yet, TSLP and IL-7 are united by key commonalities in their structure and the structural basis of the receptor assemblies they mediate to initiate cellular signaling, in particular their cross-utilization of IL-7Rα. As therapeutic targeting of TSLP and IL-7 via diverse approaches is reaching advanced stages and in light of the plethora of mechanistic and structural data on receptor signaling mediated by the two cytokines, the time is ripe to provide integrated views of such knowledge. Here, we first discuss the major pathophysiological roles of TSLP and IL-7 in autoimmune diseases, inflammation and cancer. Subsequently, we curate structural and mechanistic knowledge about receptor assemblies mediated by the two cytokines. Finally, we review therapeutic avenues targeting TSLP and IL-7 signaling. We envision that such integrated view of the mechanism, structure, and modulation of signaling assemblies mediated by TSLP and IL-7 will enhance and fine-tune the development of more effective and selective approaches to further interrogate the role of TSLP and IL-7 in physiology and disease.

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IL‐7R gene polymorphisms among patients with rheumatoid arthritis: A case–control study

Cited by 8 publications

References 32 publications

Hub gene mining and immune microenvironment analysis of autophagy in rheumatoid arthritis

Hub gene mining and immune microenvironment analysis of autophagy in rheumatoid arthritis

Correlation between IL‐7R gene variants and breast cancer susceptibility in Chinese Han women

Modulation of Signaling Mediated by TSLP and IL-7 in Inflammation, Autoimmune Diseases, and Cancer

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