<i>In silico</i>analysis and<i>in vivo</i>tests of the tuna dark muscle hydrolysate anti-oxidation effect

Han, Jiaojiao; Tang, Shu; Li, Yanyan; Bao, Wei; Wan, Haitao; Lu, Chenyang; Zhou, Jun; Li, Ye; Cheong, Ling‐Zhi; Su, Xiurong

doi:10.1039/c8ra00889b

Cited by 28 publications

(20 citation statements)

References 48 publications

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“…There were no changes induced in TC, LDL-C HDL-C, and TAG levels due to the microcapsule additive. In accordance with various reports in the literature on the subject, fish protein hydrolysate causes a reduction in these parameters’ levels in the blood serum in animals fed diets with high amounts of cholesterol [44,45]. No such effects were observed in healthy Wistar rats, which is in line with the results of our research [46].…”

Section: Resultssupporting

confidence: 93%

Furcellaran-Coated Microcapsules as Carriers of Cyprinus carpio Skin-Derived Antioxidant Hydrolysate: An In Vitro and In Vivo Study

et al. 2019

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Carp skin gelatine hydrolysate (CSGH) may be a possible bioactive peptide source, as promising antioxidant properties have been noted during in vivo testing. Hence, the present study focused on improving the bioavailability of the antioxidant peptides from CSGH and on the use of furcellaran (FUR), which can protect the biopeptides during digestion in the gastrointestinal tract. Therefore, in this study, microcapsules coated with furcellaran and containing CSGH cores were prepared. The structural properties of the sample were determined using FT-IR and SEM analysis. The antioxidant properties of hydrolysate, uncoated, and encapsulated samples were investigated. In vivo analysis included determination of its safety in an animal organism and evaluation of the lipid profile, antioxidant blood status, and mRNA expression of some genes involved in antioxidant status in Wistar rats. The results showed no adverse effects of microencapsulated protein hydrolysates in laboratory animals. Nonetheless, there was a statistically significant rise in the level of total antioxidant status blood serum among animals consuming CSGH and not inducing oxidative stress. This can be viewed as a promising indication of the positive effects of antioxidant properties tested in vivo. The process of CSGH microencapsulation in FUR cause a decrease in antioxidant hydrolysate activity, both in vitro, as well as in healthy Wistar rats. When considering the results of the presented diverse therapeutic potential, further research on CSGH being a potential bioactive peptide source used as a functional food or nutraceutical, but with a different microencapsulation coating, is encouraged.

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Section: Resultssupporting

confidence: 93%

Furcellaran-Coated Microcapsules as Carriers of Cyprinus carpio Skin-Derived Antioxidant Hydrolysate: An In Vitro and In Vivo Study

et al. 2019

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“…The composition of peptides was identified with MALID-TOF/TOF (Applied Biosystems, Foster City, CA, USA) as previously described. 23…”

Section: Tmop Preparation and Peptide Measurementmentioning

confidence: 99%

Protective effects of tuna meat oligopeptides (TMOP) supplementation on hyperuricemia and associated renal inflammation mediated by gut microbiota

Han

Tang

et al. 2020

The FASEB Journal

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Recently, interest in using whole food‐derived mixtures to alleviate chronic metabolic syndrome through potential synergistic interactions among different components is increasing. In this study, the effects and mechanisms of tuna meat oligopeptides (TMOP) on hyperuricemia and associated renal inflammation were investigated in mice. Dietary administration of TMOP alleviated hyperuricemia and renal inflammation phenotypes, reprogramed uric acid metabolism pathways, inhibited the activation of NLRP3 inflammasome and TLR4/MyD88/NF‐κB signaling pathways, and suppressed the phosphorylation of p65‐NF‐κB. In addition, TMOP treatments repaired the intestinal epithelial barrier, reversed the gut microbiota dysbiosis and increased the production of short‐chain fatty acids. Moreover, the antihyperuricemia effects of TMOP were transmissible by transplanting the fecal microbiota from TMOP‐treated mice, indicating that the protective effects were at least partially mediated by the gut microbiota. Thus, for the first time, we clarify the potential effects of TMOP as a whole food derived ingredient on alleviating hyperuricemia and renal inflammation in mice, and additional efforts are needed to confirm the beneficial effects of TMOP on humans.

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“…Food industry generally prepares the bioactive peptides with enzymatic hydrolysis using pepsin, trypsin and papain [27] or microbial fermentation [15] and some uses both methods in combination [70]. For integrated approach, most of the researchers generally combine both in vitro and in vivo studies with the in-silico approaches [71,72].…”

Section: Discussionmentioning

confidence: 99%

FermFooDb: A database of bioactive peptides derived from fermented foods

Chaudhary

Bhalla

Patiyal

et al. 2021

Heliyon

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These foods are sources of probiotic organisms and bioactive peptides, various amino acids, enzymes etc. that provides numerous health benefits. FermFooDb (https://webs.iiitd.edu.in/raghava/fermfoodb/) is a manually curated database of bioactive peptides derived from wide range of foods that maintain comprehensive information about peptides and process of fermentation. This database comprises of 2205 entries with following major fields, peptide sequence, Mass and IC50, food source, functional activity, fermentation conditions, starter culture, testing conditions of sequences in vitro or in vivo, type of model and method of analysis. The bioactive peptides in our database have wide range of therapeutic potentials that includes antihypertensive, ACE-inhibitory, antioxidant, antimicrobial, immunomodulatory and cholesterol lowering peptides. These bioactive peptides were derived from different types of fermented foods that include milk, cheese, yogurt, wheat and rice. Numerous, web-based tools have been integrated to retrieve data, peptide mapping of proteins, similarity search and multiple-sequence alignment. This database will be useful for the food industry and researchers to explore full therapeutic potential of fermented foods from specific cultures.

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In silicoanalysis andin vivotests of the tuna dark muscle hydrolysate anti-oxidation effect

Abstract: In silico prediction and in vivo confirmation of anti-oxidation effect.

Cited by 28 publications

References 48 publications

Furcellaran-Coated Microcapsules as Carriers of Cyprinus carpio Skin-Derived Antioxidant Hydrolysate: An In Vitro and In Vivo Study

Furcellaran-Coated Microcapsules as Carriers of Cyprinus carpio Skin-Derived Antioxidant Hydrolysate: An In Vitro and In Vivo Study

Protective effects of tuna meat oligopeptides (TMOP) supplementation on hyperuricemia and associated renal inflammation mediated by gut microbiota

FermFooDb: A database of bioactive peptides derived from fermented foods

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