In Silico Analysis of PTP1B Inhibitors and TLC-MS Bioautography-Based Identification of Free Radical Scavenging and α-Amylase Inhibitory Compounds from Heartwood Extract of Pterocarpus marsupium
Abstract:Type 2 diabetes mellitus leads to metabolic impairment
caused by
insulin resistance and hyperglycemia, giving rise to chronic diabetic
complications and poor disease prognosis. The heartwood of Pterocarpus marsupium has been used in Ayurveda for a long
time, and we sought to find the actual mechanism(s) driving its antidiabetic
potential. Methanol was used to prepare the extract using a Soxhlet
extraction, and the identification of metabolites was performed by
thin-layer chromatography (TLC) and ultraperforma… Show more
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