<i>In Silico</i> Analysis of the Phenylephrine from the Sand Crab (<i>Emerita asiatica)</i> for its Antimicrobial Activities

Zin, Thant; Sivakumar, J.; Sundaram, C. Shanmuga; Rao, U.S. Mahadeva

doi:10.5958/0974-360x.2019.00356.1

Cited by 6 publications

(6 citation statements)

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“…These findings were also made in the muscle tissues of Channa punctatus after exposure to Chlorpyrifos [31]. [32] Histopathological changes in the direct exposure of polluted river water on muscle tissues of Heteropneustes fossils were documented.…”

Section: Discussionmentioning

confidence: 83%

Acute Toxicity of Chlorpyrifos on Histological Alterations in the Anomuran Crab, Emerita asiatica (H. Milne Edwards, 1837)

Sivakumar¹,

Bhuvaneswari²,

Venu³

et al. 2022

AJSAT

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Acute toxicity of Chlorpyrifos on histological alterations in the different organs like gills, hepatopancreas and ovary of anomuran crab, Emerita asiatica was studied. Though Emerita asiatica is not a commercially viable crab, but it plays a vital role in the environment to maintain a stable marine ecosystem. Several steps and precautions measures should be taken to conserve these members of the marine food chain to have a stable ecosystem and also to protect this species from extinction. Thus, it can be concluded that the use of Chlorpyrifos which has been legally banned in India is justified. It has been proved by several workers and has been conformed in present investigation that use of this Chlorpyrifos causes serious damage to the vital organ of sand crabs gill, hepatopancreas and ovary. The application of Chlorpyrifos could be reduced in the agricultural field to nearby coastal regions.

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Section: Discussionmentioning

confidence: 83%

Acute Toxicity of Chlorpyrifos on Histological Alterations in the Anomuran Crab, Emerita asiatica (H. Milne Edwards, 1837)

Sivakumar¹,

Bhuvaneswari²,

Venu³

et al. 2022

AJSAT

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“…Hypoxia, respiratory failure, and issues with the ionic and acid-base balance are all possible outcomes of the histological changes in the gill [29]. The observed histological effects of hyperplasia, necrosis, and lamellar aneurysms in the exposed crab in response to sub lethal concentrations of Monocrotophos are compatible with changes in the gill surfaces and increased mucus production.…”

Section: Discussionmentioning

confidence: 89%

“…Hemocytes are the most crucial type of cellular defense in crustaceans, so abnormal infiltration of hemocytes in the interstitial sinuses found in the hepatopancreas of test animals suggests that the mechanism of cellular/host defense was in operation to neutralize the tissue damage caused by Monocrotophos [29]. The development of necrotic hepatopancreatic tubules in test crabs shows that the hepatopancreas of E. asiatica subjected to the maximum sub-lethal dosage of Monocrotophos experienced cell deformation, disintegration, and death.…”

Section: Discussionmentioning

confidence: 99%

“…According to [29], Macrobrachiumlamerrei subjected to low (0.0065 ppm) and high (0.0215 ppm) copper concentrations underwent alterations such as elongation of hepatopancreatic cells and shrunken cells. The hepatopancreas and gills of Penaeus indicus exposed to Zn at a low concentration of 100 ppb underwent destructive and degenerative alterations [27].…”

Section: Discussionmentioning

confidence: 99%

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Acute Toxicity of Monocrotophos on Histological Alterations in the Anomuran Crab, Emerita asiatica (H. Milne Edwards, 1837)

Sivakumar¹,

Bhuvaneswari²,

Venu³

et al. 2022

AJEAT

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This study characterized the acute toxicity of Monocrotophos on histological alterations in the different organs like gills, Hepatopancreas and ovary of Anomuran Crab, Emerita asiatica. Though Emerita asiatica is not a commercially viable crab, but it plays a vital role in the coastal environment to maintain a stable marine ecosystem. Several steps and precautions measures should be taken to consume these members of the marine food chain to have aunwavering ecosystem and also to protect this species from extinction. Thus, it can be concluded that the use of Monocrotophos which has been legally banned in India is justified. It has been proved by several workers and has been conformed in present investigation that use of this organophosphate causes serious damage to the vital organ of sand crabs gill, hepatopancreas and ovary. The utilization of Monocrotophos should be minimized in the agricultural field area near to the coastal ecosystem.

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“…Anti-convulsant, anti-neoplastic agents, anti-oxidants, anti-microbial activities [12] 1-Octen-3-ol A strong anti-bacterial, inhibition of the growth of insects [13], a profound influence on protein expression patterns, blocking isotropic growth, mild physiological effects on germinating conidia in solution [14] Phenylephrine Alpha-adrenergic agonist, decongestant, anti-bacterial activity [15] 2-Furanmethanol, 5-ethenyltetrahydro-. alpha.,.alpha.,5trimethyl-, cis Anti-viral, anti-oxidative activities [16]…”

Section: -Dodecen-1-yl(-) Succinic Anhydridementioning

confidence: 99%

Volatile Constituents and Toxicity of Essential Oils Extracted From Aerial Parts of Plantago Lanceolata and Plantago Major Growing in Iran

Haghighi¹,

Yazdinezhad²,

Bagheri³

et al. 2022

PBR

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Background:Plantago lanceolata L. (P. lanceolate) and Plantago major L. (P. major) belong to the Plantaginaceae family and are widely used in traditional medicine. Objectives: This study aims to qualitatively identify the crucial compounds and evaluate the toxicity effects of essential oils of two Plantago species. Methods: The plantains were collected from Zanjan Province, Iran. The essential oils were extracted by hydrodistillation and then analyzed using gas chromatography coupled with mass spectrometry (GC/MS). The toxicity effects of the essential oils were evaluated on HCT-116 and HEK-293 cell lines (in vitro MTT assay) and Artemia salina (A.salina) (in vivo assay). The constituents of the essential oils were identified by calculating their retention indices under temperature-programmed conditions for n-alkanes (C8 -C20) in the Agilent 19091S-433 column. Results: The main identified constituents were metaraminol (14.04%), bifemelane (8.73%), metossamina (8.16%), and pterin-6-carboxylic acid (5.11%) in P. lanceolata and 2-dodecen-1-yl (-) succinic anhydride (15.29%), benzenemethanol, α-(1-aminoethyl)-2,5- dimethoxy-(11.83%), dl-phenylephrine (7.51%), and nortriptyline (5.15%) in P. major. The essential oils of P. major exhibited more antiproliferative properties on HCT-116 at 72 h compared to P. lanceolata (IC50: 102.66 µg/mL). At 400 µg/mL of P. lanceolata and P. major, the percentage of the lethality of nauplii was 8% and 12%, respectively (LC50:2242.57 µg/ mL and 1783.7 µg/mL). The present study showed that the most of constituents of oils were alcohols and amines. Conclusion: Some of the compounds identified in the Plantago species essential oils have important pharmaceutical properties. This study reported the cytotoxicity of essential oils on the colon cancer cell line. However, the essential oils were not toxic against A.salina at the examined concentrations.

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In Silico Analysis of the Phenylephrine from the Sand Crab (Emerita asiatica) for its Antimicrobial Activities

Cited by 6 publications

References 0 publications

Acute Toxicity of Chlorpyrifos on Histological Alterations in the Anomuran Crab, Emerita asiatica (H. Milne Edwards, 1837)

Acute Toxicity of Chlorpyrifos on Histological Alterations in the Anomuran Crab, Emerita asiatica (H. Milne Edwards, 1837)

Acute Toxicity of Monocrotophos on Histological Alterations in the Anomuran Crab, Emerita asiatica (H. Milne Edwards, 1837)

Volatile Constituents and Toxicity of Essential Oils Extracted From Aerial Parts of Plantago Lanceolata and Plantago Major Growing in Iran

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