<i>In silico</i> and <i>in vitro</i> studies of transition metal complexes derived from curcumin–isoniazid Schiff base

Jeyaraman, Porkodi; Arunadevi, Alagarraj; Natarajan, Raman

doi:10.1080/07391102.2019.1581090

Cited by 37 publications

(11 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The strong band observed at 1658 cm -1 may be attributed to >C=O stretching vibration of urethane [37], while the bands at 1533 cm -1 may be assigned to N-H out of plane bending in urethane [38], while the band at 1043 cm -1 may be corroborated to C-O-C stretching vibration. [39] The spectral data of M(II)-HTPU 300 [where, M = Mn(II) d 5 , Co (II) d 7 , Ni(II) d 8 and Zn(II) d 10 ] can be extensively discussed. The peak centered between 3277-3300 cm -1 may be ascribed to -NH stretching vibration while the strong peak appearing between 1696-1712 cm -1 may be assigned to >C=O stretching vibration of urethane groups.…”

Section: Electrical Conductivitymentioning

confidence: 99%

See 1 more Smart Citation

Transition Metal-Ions Incorporated PEG300 and TDI Based Hydroxy-Terminated Polyurethanes

Laxmi¹,

Shahzaib²,

Khan³

et al. 2021

Preprint

View full text Add to dashboard Cite

Present work reports the synthesis of polyethylene glycol, PEG 300 (soft segment) and toluene 2,4-diisocyanate, TDI (hard segment) based hydroxy-terminated polyurethane ligands (HTPU300) for the first time to the best of our knowledge. The effect of 3d transition metal ions with different 3d electrons within HTPU (M(II)-HTPU300, M= Mn, Co, Ni, and Zn) was evaluated by their physical and antibacterial studies of the final complex polymeric unit. M(II) HTPU300 and was conveniently synthesized in appreciable yields following a facile and one-pot addition polymerization reaction scheme. Foremost the thermal stability of all the M(II)-HTPU300 polymeric materials were evaluated using TGA, DSC, and IPDT calculations. FTIR technique was used to ascertain the structure of M(II)-HTPU300, while SEM/EDX and XRD techniques were used to study their morphology, elemental analysis, and crystalline nature of the material, respectively. Further, the in-vitro antimicrobial activity of the PU was investigated against gram-positive (Staphylococcus aureus, Bacillus subtilis) and gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacterial strains. The comparatively moderate efficacy against bacterial stain supports the possible application of such PU as thermally stable bacterial resistant materials constructed out of degradable PEG.

show abstract

Section: Electrical Conductivitymentioning

confidence: 99%

“…Schiff bases [5], porphyrins, N-heheterocycles [6], polyureas [7], and polyurethanes (PUs) [8]. The chemical and structural properties of PUs can easily be modulated to generate tailored polymers with predetermined features [9].…”

Section: Introductionmentioning

confidence: 99%

Transition Metal-Ions Incorporated PEG300 and TDI Based Hydroxy-Terminated Polyurethanes

Laxmi¹,

Shahzaib²,

Khan³

et al. 2021

Preprint

View full text Add to dashboard Cite

show abstract

“…The most signicant antibacterial and antifungal activities were shown by Cu(II) complex. 53 Recently, the hydrazone compound 31, as a tautomeric form, was prepared by reaction of 2-hydrazinobenzothiazole and curcumin in a 2 : 1 molar ratio. The copper(II) coordination complexes in 1 : 1 and 1 : 2 molar ratios were synthesized using the copper chloride, bromide, acetate and nitrate by template method.…”

Section: Hydrazone Derivatives Of Curcuminmentioning

confidence: 99%

A review on biological activities of Schiff base, hydrazone, and oxime derivatives of curcumin

2020

View full text Add to dashboard Cite

show abstract

“…The computational analysis dealing with biological activity prediction, cell line cytotoxicity, acute rate toxicity 24 , environmental toxicity and docking studies were carried out 17,3 .…”

Section: Computational Studiesmentioning

confidence: 99%

“…Conflicting intercalators, groove binders inevitability partake springy structures 16 . DNA (Deoxyribo Nucleic Acid) straighten out effectiveness of the metallic multiplexes takes stayed comprehensively deliberate towards pinpoint their impending as anti-cancer medications [17][18] .…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Spectral Characterization, Computational Revisions, Toxicology Studies In Addition To Biotic Studies of O-Phenylenediamine Based Schiff Base and Its Transition Metal Complexes

Indra¹,

Xavier²,

Harinathan³

2020

AJPTR

View full text Add to dashboard Cite

E)-2-(1-((2-aminophenyl)imino)ethyl)phenol (APIEP) was charity in place of a ligand in lieu of the synthesis of a succession of metallic multiplexes, wherever the metals were Ni(II), Fe(III) and Zn(II). The structural sorts of the ligand in addition to the contrived multiplexes remained characterized by means of numerous spectral as well as diagnostic practices. FT-IR spectra exhibited that the liberty ligand APIEP accomplishes by means of tridentate with hydroxyl, amine and imine moiety were co-ordination sites to all the metal ions. The FT-IR stretching frequency for the above co-ordination sites were varied after co-ordination with Ni(II), Fe(III) then Zn(II) metallic salts. The metallic complexes exhibits octahedral geometry, it was confirmed by spectral techniques. Natal activities of the ligand APIEP voguish accumulation en route on behalf of its multiplexes have remained verified against anti-oxidant and anti-microbial strains. All the metallic multiplexes partake superior biotic doings than the free APIEP. The computational analysis like biological activity prediction, cell line cytotoxicity, acute rate toxicity, environmental toxicity and docking of the samples were done with online software and commercial docking software.

show abstract

In silico and in vitro studies of transition metal complexes derived from curcumin–isoniazid Schiff base

Cited by 37 publications

References 50 publications

Transition Metal-Ions Incorporated PEG300 and TDI Based Hydroxy-Terminated Polyurethanes

Transition Metal-Ions Incorporated PEG300 and TDI Based Hydroxy-Terminated Polyurethanes

A review on biological activities of Schiff base, hydrazone, and oxime derivatives of curcumin

Synthesis, Spectral Characterization, Computational Revisions, Toxicology Studies In Addition To Biotic Studies of O-Phenylenediamine Based Schiff Base and Its Transition Metal Complexes

Contact Info

Product

Resources

About