2024
DOI: 10.1002/cbdv.202401629
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In Silico and In Vitro Evaluation of Quinoline Derivatives as Potential Inhibitors of AChE, BACE1, and GSK3β for Neurodegenerative Diseases Treatment

Bruno Assis de Oliveira,
Filipe Gonçalves de Oliveira,
Otávio de Assis Cruz
et al.

Abstract: Neurodegenerative diseases are characterized by the structural and functional loss of neurons, affecting populations worldwide. Enzymes like acetylcholinesterase (AChE), beta‐site APP cleaving enzyme‐1 (BACE1), and glycogen synthase kinase 3‐beta (GSK3β), contribute to their development. This study explores in silico and in vitro assays of quinoline analogues as potential inhibitors of these enzymes. In silico analyses highlighted derivative SQ6 as the most potent inhibitor for all proteins. In vitro assays co… Show more

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