2024
DOI: 10.1039/d4sm00171k
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In silico design of misfolding resistant proteins: the role of structural similarity of a competing conformational ensemble in the optimization of frustration

Bondeepa Saikia,
Anupaul Baruah

Abstract: Most state of the art in silico design methods fail due to misfolding of designed sequences to a conformation other than the target. Thus, a method to design misfolding resistant...

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