In silico Design, Synthesis and Biological Evaluation of Novel Thieno[3,2‐d]pyrimidine Derivatives for Cancer Therapy – A Preliminary Study on the Inhibitory Potential towards ATR Kinase Domain and PIKK Family
Samvel N. Sirakanyan,
Haritha Dilip,
Athina Geronikaki
et al.
Abstract:Continuing our studies in the field of new heterocyclic compounds with biological interest, herein we report the synthesis and anticancer activity of new N‐ and S‐substituted derivatives of tetracyclic pyrido[3',2':4,5]thieno[3,2‐d]pyrimidines. In this regard, starting from the thieno[2,3‐b]pyridine‐2‐carboxylates, the corresponding 8(9)‐aminopyrido[3',2':4,5]thieno[3,2‐d]pyrimidin‐7(8)‐ones, as well as chloro derivatives were obtained. Based on the latter, amino, hydrazino and S‐alkyl derivatives of pyrido[3'… Show more
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