<i>In silico</i>mechanistic disposition and<i>in vivo</i>evaluation of zero-order drug release from a novel triple-layered tablet matrix

Moodley, Kovanya; Choonara, Yahya E.; Kumar, Pradeep; Toit, Lisa C. du; Pillay, Viness

doi:10.1517/17425247.2015.989208

Expert Opinion on Drug Delivery

2014

DOI: 10.1517/17425247.2015.989208

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In silicomechanistic disposition andin vivoevaluation of zero-order drug release from a novel triple-layered tablet matrix

Kovanya Moodley

Yahya E. Choonara

Pradeep Kumar

et al.

Abstract: The formulation with a lower s-PLGA:PEO ratio displayed superior zero-order release. Relatively, linear drug release was achieved from the middle-layer. The in vivo results proved the applicability of optimized TLT formulation in a therapeutic cardiovascular drug treatment regimen.

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In vitro and in vivo evaluation of controlled-release matrix tablets of highly water-soluble drug applying different mw polyethylene oxides (PEO) as retardants

Wen

et al. 2017

Drug Development and Industrial Pharmacy

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The aim of the work presented is to prepare a controlled-release hydrophilic matrix tablet (CMT) controlling release of highly water-soluble drug applying pure combination of high- and low-Mw PEO as matrix materials, to avoid the lag time of drug release, and to overcome incomplete release in later stages. The influences of types and amounts of different Mw PEOs used, drug loading, pH of release medium and agitation rate on drug release were evaluated. The study of uptake and erosion of matrix was conducted and mechanism of improving drug release was discussed. In vivo pharmacokinetics of the CMT and reference preparation self-made controlled-release osmotic pump tablets (COPT) were performed in beagle dogs. The optimized formulation containing 43% PEO WSR 303 and 32% PEO N750 showed a zero order release from 1 h to 12 h. In vivo results demonstrated that the CMT had similar AUC and C with the COPT but smaller T than the COPT and provided a more stable therapeutic concentration compared to the COPT. In conclusion, hydrophilic matrix tablet combining only different Mw PEOs as matrix materials had very good potential to be developed into a controlled-release drug delivery system for highly water-soluble drug. Besides, its manufacturing processes were succinct which would be preferable for modern medicine industry.

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In vitro and in vivo evaluation of controlled-release matrix tablets of highly water-soluble drug applying different mw polyethylene oxides (PEO) as retardants

Wen

et al. 2017

Drug Development and Industrial Pharmacy

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show abstract

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In silicomechanistic disposition andin vivoevaluation of zero-order drug release from a novel triple-layered tablet matrix

Abstract: The formulation with a lower s-PLGA:PEO ratio displayed superior zero-order release. Relatively, linear drug release was achieved from the middle-layer. The in vivo results proved the applicability of optimized TLT formulation in a therapeutic cardiovascular drug treatment regimen.

Cited by 1 publication

References 39 publications

In vitro and in vivo evaluation of controlled-release matrix tablets of highly water-soluble drug applying different mw polyethylene oxides (PEO) as retardants

In vitro and in vivo evaluation of controlled-release matrix tablets of highly water-soluble drug applying different mw polyethylene oxides (PEO) as retardants

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