2024
DOI: 10.1101/2024.06.26.600687
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In silicoscreening identifies SHPRH as a novel nucleosome acidic patch interactor

Allison M. James,
Ernst W. Schmid,
Johannes C. Walter
et al.

Abstract: Nucleosomes are the fundamental unit of eukaryotic chromatin. Diverse factors interact with nucleosomes to modulate chromatin architecture and facilitate DNA repair, replication, transcription, and other cellular processes. An important platform for chromatin binding is the H2A–H2B acidic patch. Here, we used AlphaFold-Multimer to screen over 7000 human proteins for nucleosomal acidic patch binding and identify 41 potential acidic patch binders. We determined the cryo-EM structure of one hit, SHPRH, with the n… Show more

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