In situ chemichromic studies of interactions between a lutetium bis-octaalkyl-substituted phthalocyanine and selected biological cofactors

Abstract

Spin-coated films, approximately 100 nm thick, of a newly synthesized bis[octakis(octyl)phthalocyaninato] lutetium(III) complex on ultrasonically cleaned glass substrates exhibit pronounced chemichromic behaviour with potential application in healthcare. In situ kinetic optical absorption spectroscopic measurements show that the phthalocyanine Q-band is red shifted by 60 nm upon oxidation arising from exposure to bromine vapour. Recovery to the original state is achieved by the treatment of the oxidized films with nicotinamide adenine dinucleotide and L-ascorbic acid (vitamin C) in an aqueous solution containing 1.5 M lithium perchlorate. The neutralization process is found to be governed by first-order kinetics. The linear increase of the reduction rate with increasing concentration of cofactors provides a basis for calibration of analyte concentrations ranging from 3.5 mM down to 0.03 mM.

Electrochemical Detection of 4‐Chlorophenol Using Glassy Carbon Electrodes Modified with Thulium Double‐Decker Phthalocyanine Salts

“…LnPc 2 complexes exhibit better electrochemical and electrochromic properties than their metallo monophthalocyanine (MPc) analogues . So far, the spectro‐electrochemical methods for the detection of nicotinamide adenine dinucleotide or the impendence and frequency‐based techniques for gas sensing have been demonstrated for LnPc 2 complexes . We report on the electrochemical sensing of LnPc 2 complexes using cyclic voltammetry (CV).…”

Channel length-dependent characterisations of organic thin-film transistors with solution processable gadolinium phthalocyanine derivatives

“…Redox peaks shifted towards the negative potentials as a function of the decreasing metal ion size [7]. Studies on chemichromic interactions between lutetium bis-octaalkylsubstituted phthalocyanines and biological cofactors namely nicotinamide adenine dinucleotide and l-ascorbic acid of concentrations ranging from 3.5 mM down to 0.03 mM can be adapted for developing practical devices in plasma, serum, red cells, urine and other accessible tissues for biochemical and functional status [8]. These complexes may potentially be used as emitters in different types of organic light-emitting diodes, depending upon their emission wavelengths.…”

Development of glucose biosensors using nanostructured composites

“…Among numerous metallophthalocyanine (MPc) families, doubledecker lanthanide derivatives (see Figure 2-12) such as lutetium phthalocyanine (LuPc 2 ), Dysprosium phthalocyanine (DyPc 2 ), Europium phthalocyanine (EuPc 2 ), Gadolinium phthalocyanine (GdPc 2 ), Neodymium phthalocyanine (NdPc 2 ), and Samarium phthalocyanine (SmPc 2 ) attract interest due to their high intrinsic conductivity and electrochemical properties . The electrochromic behaviour of lanthanide phthalocyanine films has been used for the detection of nicotinamide adenine dinucleotide (Galanin and Shaposhnikov, 2012a;Pal et al, 2011).…”

“…Among numerous MPcs, double-decker lanthanide derivatives, such as lutetium phthalocyanine (LuPc 2 ) attract interest due to their high intrinsic conductivity and electrochemical properties . The electrochromic behaviour of lanthanide phthalocyanine films has been used for the detection of nicotinamide adenine dinucleotide (Pal et al, 2011;Galanin and Shaposhnikov, 2012a).…”

“…Al-Sagur and coworkers reported on glucose biosensor construction using LuPc 2 as redox mediator decorated in conducting polymer hydrogel (Al-Sagur et al, 2017). Thin films of LuPc 2 have been used for the detection of nicotinamide adenine dinucleotide and volatile organic compounds (Açikbaş et al, 2009;Galanin and Shaposhnikov, 2012a;Pal et al, 2011). Physico-chemical properties of LuPc 2 complexes are utilized for the photoconversion of 4-nitrophenol (Zugle and Nyokong, 2012).…”