<i>In situ</i> development and application of natural coatings on non-absorbable sutures to reduce incision site infections

Masood, Rashid; Hussain, Tanveer; Umar, Muhammad Naveed; Azeemullah,; Areeb, Tanzeel; Riaz, Shagufta

doi:10.12968/jowc.2017.26.3.115

Cited by 18 publications

(16 citation statements)

References 2 publications

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“…The coating of medical material with titanium material can be seen as leadoff technique in medicine, therefore scientific literature on this topic is rare. Notwithstanding, our findings can be seen as consistent with the advantages of coating suture material with chemicals [11][12][13][14][15][16] or metal legions, like the prevention of surgical site infections [17][18][19][20]. They were also in accordance with beneficial qualities of titanium in medical products, like excellent bone to implant bonding, high biocompatibility due to low allergic potential, resistance to corrosion and limited complications like wound dehiscence, infection and pain [21][22][23][24][25][26][27].…”

Section: Discussionsupporting

confidence: 85%

“…Not only implanted foreign bodies, yet also suture material have to be taken into consideration as a host for biofilm and therefore a potential source of infection [7,9,10]. In order to surmount this issue, the coating of suture material not only with chemicals such as triclosan [11][12][13][14][15][16], yet also with metal legions is not uncommon in medicine. Silver nanoparticle-coatings on silk suture for example have proven to be successful in the prevention of surgical site infections [17][18][19][20].…”

Section: Introductionmentioning

confidence: 99%

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Scar Quality Examination Comparing Titanium Coated Suture Material and Non-Coated Suture Material on Flap Donor sites in Reconstructive Surgery

Berninghausen

Osterhoff

Langer

et al. 2020

Preprint

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OBJECTIVES Wound healing and scar quality after trauma are subject to impairment through excessive wound healing, chronic wound or even surgical site infections. Optimizing the process of scar formation and skin healing is crucial in virtually all fields of medicine. In this regard, we tested the possible usage and advantages of titanium coated suture material. METHODS We performed a prospective observational cohort study including 30 patients who underwent soft tissue reconstruction. One half of the donor flap site was sutured with titanium coated suture material, while the other half was closed with non-coated sutures . Scar quality of the donor flap site was assessed by photographs and POSAS scores on days 2-5, 14, 42, 72 and 180 postoperatively. RESULTS No difference between the titanium coated sutures and non-coated sutures was seen in the POSAS assessment, neither for the patient scale at 14, 42, 72 and 180 days, nor for the observer scale on the same dates. Comorbidities like diabetes, chronic renal failure and smoking as well as the BMI of each patient affected the wound healing process to an equal degree on both sides of the suture. CONCLUSION No difference between titanium coated and non-titanium-coated suture material was seen in the POSAS assessment in regard to scar quality and wound healing. The titanium-coated suture material can be considered to be equally as effective and safe in all qualities as the non-titanium-coated suture material, even in patients with comorbidities.

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Section: Discussionsupporting

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Scar Quality Examination Comparing Titanium Coated Suture Material and Non-Coated Suture Material on Flap Donor sites in Reconstructive Surgery

Berninghausen

Osterhoff

Langer

et al. 2020

Preprint

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“…Similarly, to our study, it appears that the coating slightly improved the tensile strength of the sutures after the application of natural coatings on non-absorbable sutures. [28,29] Consequently, the results of our experiment did partially support our hypothesis. The chitosan coating over the sutures ameliorates the adhesion scores, the tensile strength, or the histopathological criteria in some parts over the reinforcement of anastomosis.…”

Section: Discussionsupporting

confidence: 66%

The effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis

Altınel

Chung²,

Okay

et al. 2018

Ulus Travma Acil Cerrahi Derg

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BACKGROUND: We evaluated the feasibility of chitosan-coated sutures for intestinal anastomosis strength through wound-healing effect. METHODS: Vicryl and PDS sutures were coated with 2% chitosan. While laparotomy was applied to the first group, chitosan was applied in the peritoneal cavity in the second group. Then the following materials were applied to colon anastomosis, in order: Vicryl, PDS, chitosan-coated Vicryl, and chitosan-coated PDS sutures. On the 7 th and 14 th days, eight rats from each group were euthanized. RESULTS: The adhesion scores of chitosan and control groups were lower than the suture groups. The vascularization of Vicryl-chitosan was lower than PDS-chitosan on the 14 th day (p=0.038). Fibroblast cells and vascularization of anastomosis with chitosan-coated Vicryl were lower than Vicryl and chitosan-coated PDS on the 14th day (p<0.05). The tensile strength of Vicryl-chitosan increased more than Vicryl in vitro (p<0.05) on the 14 th and 7 th days, but there was no difference in vivo. The tensile strength of PDS-chitosan decreased more than PDS on the 7 th day in vivo (p<0.05). CONCLUSION: The chitosan-coating effect on the adhesion and reinforcement of anastomosis in some parts of Vicryl in vitro and PDS in vivo was slightly improved.

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“…As a critical treatment medium, polymer‐based functional materials are widely applied to treat various stages of CVI because of their unique physical, mechanical, chemical, and biological properties (Cornish, ; Pang, Ibrahim, Bulstrode, & Ferretti, ). These materials are mainly fabric‐based compression devices (e.g., compression stockings (Hobson et al, ), compression bandages (Wiklander, Andersson, & Källman, ), and intermittent pneumatic pump) used to treat CVI with C 1 – C 6 symptoms, and functional wound dressings (e.g., scaffolds (Dickinson & Gerecht, ), pads (Brown, ), and sutures (Masood et al, )) to facilitate primary treatment of leg ulceration (i.e., classes C 5 – C 6 ) (Figure ).…”

Section: Introductionmentioning

confidence: 99%

“…These materials are mainly fabric-based compression devices (e.g., compression stockings (Hobson et al, 2017), compression bandages (Wiklander, Andersson, & Källman, 2016), and intermittent pneumatic pump) used to treat CVI with C 1 -C 6 symptoms, and functional wound dressings (e.g., scaffolds (Dickinson & Gerecht, 2016), pads (Brown, 2016), and sutures (Masood et al, 2017)) to facilitate primary treatment of leg ulceration (i.e., classes C 5 -C 6 ) ( Figure 1).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic compression materials and wound dressings for chronic venous insufficiency: A comprehensive review

Liu

Lao

2019

J Biomed Mater Res

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Chronic venous insufficiency (CVI) is a common disorder worldwide. Related pathophysiological mechanisms reportedly involve venous pooling and reduced venous return, leading to heaviness, aching, itchiness, tiredness, varicosities, pigmentation, and even lower limb ulceration. Approaches adopted to manage CVI at various stages of clinical‐etiology‐anatomy‐pathophysiology include compression therapy, pharmacological treatment, ultrasound treatment, surgery, electrical or wireless microcurrent stimulation, and pulsed electromagnetic treatment. Among these, polymer‐based therapeutic compression materials and wound dressings play increasingly key roles in treating all stages of CVI because of their unique physical, mechanical, chemical, and biological functions. However, the characteristics, working mechanisms, and effectiveness of these CVI treatment materials are not comprehensively understood. The present systematic review examines the structures, properties, types, and applications of various polymer‐based compression materials and wound dressings used in prophylaxis and treatment of CVI. Existing problems, limitations, and future trends of CVI treatment materials are also discussed. This review could contribute to the design and application of new functional polymer materials and dressings to enhance the efficiency of CVI treatments, thereby facilitating patients' self‐care ability and long‐term health improvement.

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In situ development and application of natural coatings on non-absorbable sutures to reduce incision site infections

Cited by 18 publications

References 2 publications

Scar Quality Examination Comparing Titanium Coated Suture Material and Non-Coated Suture Material on Flap Donor sites in Reconstructive Surgery

Scar Quality Examination Comparing Titanium Coated Suture Material and Non-Coated Suture Material on Flap Donor sites in Reconstructive Surgery

The effect of chitosan coating on surgical sutures to strengthen the colonic anastomosis

Therapeutic compression materials and wound dressings for chronic venous insufficiency: A comprehensive review

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