<i>In-situ</i>fabrication of gold nanoparticle functionalized probes for tip-enhanced Raman spectroscopy by dielectrophoresis

Sweetenham, Claire S.; Woolley, Richard A. J.; Notingher, Ioan

doi:10.1117/1.jnp.10.030502

Cited by 8 publications

(8 citation statements)

References 20 publications

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“…To prevent or restrain the randomness of hot spot localization (unavoidable in metal films) and improve the manufacturing reproducibility of AFM‐TERS tips, selective decoration of tip apexes with Ag, Au, and Au–Ag core–shell NPs was performed by means of laser‐induced synthesis, dielectrophoresis, or applying the pick‐up process on dendron‐modified AFM tips followed by the growth of an Ag shell or Au spikes . Microfabrication methods (FIB milling, photolithography, …) also attracted much interest due to their ability to manufacture highly reproducible nanostructures with relatively high electromagnetic field enhancements.…”

Section: Experimental Developments In Tersmentioning

confidence: 99%

Tip‐Enhanced Raman Spectroscopy: A Tool for Nanoscale Chemical and Structural Characterization of Biomolecules

Bonhommeau

Lecomte

2017

ChemPhysChem

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Due to its high molecular sensitivity and spatial optical resolution down to sub‐nanometer values, tip‐enhanced Raman spectroscopy (TERS) has emerged as a powerful microscopy technique for nanoscale characterization. Progress in TERS instrumentation and in the manufacturing of efficient TERS tips allow for chemical and structural analysis under various experimental conditions (different wavelengths, substrates, and surrounding media). Many biological species have been examined by using this technique. Nucleic acids (individual nucleobases, DNA, and RNA) can show specific TERS features that reveal their composition, conformation, and defects. TERS studies on peptides and proteins (such as amyloid fibrils) provide relevant information on their morphology and structure, leading to valuable insight to their functions and behavior. Finally, lipid layers and membranes, viruses, bacteria, and cells can also be finely characterized. Generalizing TERS measurements in liq‐ uid medium to study biological systems is the main future challenge.

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Section: Experimental Developments In Tersmentioning

confidence: 99%

Tip‐Enhanced Raman Spectroscopy: A Tool for Nanoscale Chemical and Structural Characterization of Biomolecules

Bonhommeau

Lecomte

2017

ChemPhysChem

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“…This is something that has been a typical issue for TERS. 28,29 Attention has as a result shifted towards tips based around colloidal noble metal nanoparticles, [30][31][32] the synthesis of which falls within the domain of 'bottom-up' nano-engineering. The shape, size and composition of such particles can be readily controlled with high homogeneity and on a large scale, making them ideal for plasmonic applications.…”

Section: Introductionmentioning

confidence: 99%

Silver nanowires for highly reproducible cantilever based AFM-TERS microscopy: towards a universal TERS probe

et al. 2018

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Tip-enhanced Raman scattering (TERS) microscopy is a unique analytical tool to provide complementary chemical and topographic information of surfaces with nanometric resolution. However, difficulties in reliably producing the necessary metallized scanning probe tips has limited its widespread utilisation, particularly in the case of cantilever-based atomic force microscopy. Attempts to alleviate tip related issues using colloidal or bottom-up engineered tips have so far not reported consistent probes for both Raman and topographic imaging. Here we demonstrate the reproducible fabrication of cantilever-based high-performance TERS probes for both topographic and Raman measurements, based on an approach that utilises noble metal nanowires as the active TERS probe. The tips show 10 times higher TERS contrasts than the most typically used electrochemically-etched tips, and show a reproducibility for TERS greater than 90%, far greater than found with standard methods. We show that TERS can be performed in tapping as well as contact AFM mode, with optical resolutions around or below 15 nm, and with a maximum resolution achieved in tapping-mode of 6 nm. Our work illustrates that superior TERS probes can be produced in a fast and cost-effective manner using simple wet-chemistry methods, leading to reliable and reproducible high-resolution and high-sensitivity TERS, and thus renders the technique applicable for a broad community.

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“…Recently nanoparticle attachment methods using dielectrophoresis have also been explored by several groups [357][358][359].…”

Section: Typical Systemmentioning

confidence: 99%

Raman spectroscopy: techniques and applications in the life sciences

Shipp¹,

Sinjab²,

Notingher³

2017

Adv. Opt. Photon.

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270

189

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Raman spectroscopy is an increasingly popular technique in many areas including biology and medicine.It is based on Raman scattering, a phenomenon in which incident photons lose or gain energy via interactions with vibrating molecules in a sample. These energy shifts can be used to obtain information regarding molecular composition of the sample with very high accuracy. Applications of Raman spectroscopy in the life sciences have included quantification of biomolecules, hyperspectral molecular imaging of cells and tissue, medical diagnosis, and others. This review briefly presents the physical origin of Raman scattering explaining the key classical and quantum mechanical concepts. Variations of the Raman effect will also be considered, including resonance, coherent, and enhanced Raman scattering. We discuss the molecular origins of prominent bands often found in the Raman spectra of biological samples. Finally, we examine several variations of Raman spectroscopy techniques in practice, looking at their applications, strengths, and challenges. This review is intended to be a starting resource for scientists new to Raman spectroscopy, providing theoretical background and practical examples as the foundation for further study and exploration.

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In-situfabrication of gold nanoparticle functionalized probes for tip-enhanced Raman spectroscopy by dielectrophoresis

Cited by 8 publications

References 20 publications

Tip‐Enhanced Raman Spectroscopy: A Tool for Nanoscale Chemical and Structural Characterization of Biomolecules

Tip‐Enhanced Raman Spectroscopy: A Tool for Nanoscale Chemical and Structural Characterization of Biomolecules

Silver nanowires for highly reproducible cantilever based AFM-TERS microscopy: towards a universal TERS probe

Raman spectroscopy: techniques and applications in the life sciences

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