In situfabrication of HDA-mediated NiFe–Fe₂O₃nanorods: an efficient and recyclable heterogeneous catalyst for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in water

Abstract

A promising strategy for the synthesis of pharmaceutically important scaffold 2,3-dihydroquinazolin-4(1H)-ones through heterogeneous catalysis employing the principle of multicomponent reaction has been presented in this paper. For the purpose, a...

Synthesis of Nitrogen- and Oxygen-Containing Heterocycles Catalysed by Metal Nanoparticles Reported in 2022

“…The selective transfer hydrogenation of 44 to give 45 Saeedi and Rahmati published the synthesis of biodegradable heterogeneous catalysts, MNP-cellulose-OSO 3 H by functionalisation of Fe 3 O 4 MNPs with chlorosulfonic acid. 80 The synthesis of trisubstituted imidazoles (96) was attained from benzil or 9,10-phenanthrenoquinone (94), substituted benzene carbaldehyde (47) and ammonium acetate (95) in EtOH solvent at 80 °C for 2 h in the catalytic presence of MNP-cellulose-OSO 3 H (Scheme 27). The catalysts were found to possess sufficient performance and efficient reusability in up to four consecutive cycles.…”

“…Fe 2 O 3 NPs were formed via calcination, functionalised with silane and coated with silica followed by their immobilisation using Co(II) salts. BET revealed the dimension of MNPs in the range of (83), ammonium acetate (95), different aldehydes (88) and ethyl acetoacetate (154), catalysed via the Hantzsch reaction with ethanol as the solvent in excellent yields (91-95%).The catalyst retained its activity for five successive runs. The authors reported the successful synthesis of quinazolines using substituted benzaldehyde, dimedone, and urea using the same catalysts in ethanol at 60 102 Sulfonic acid functionalised silicacoated CoFe 2 O 4 NPs were synthesised using the co-precipitation method, and then altered with chlorosulfonic acid.…”

“…Herein, SEM analysis revealed the NPs to have the particle size in the range of 47-55 nm. The synthesis of chromeno derivatives (207) was attained through the cyclocondensation of malononitrile (48), -naphthol (206), ammonium acetate (95) and aryl aldehydes (47) in ethanol in moderate to excellent yields. The quinazoline derivatives (209) were synthesised by the cyclocondensation of anthranilamide (208) and aldehydes (47) in 30-95% yields.…”

“…Omidi and Mobinikhaledi synthesised MnCoFe 2 O 4 -SO 3 H NPs functionalised with pyridinium chloride, generated by coating the sulfonic group on MnCoFe 2 O 4 @Niacin. 116 The NPs were synthesised from a mixture of manganese(II) chloride, cobalt(II) chloride and ferric chloride hydrates, and their catalytic activities were reported for the multi-component synthesis of tetrahydrodipyrazolopyridines (212; Scheme 63), which were synthesized using aldehydes (210), ammonium acetate (95), ethyl acetoacetate (154) and substituted hydrazine derivatives (211) in 82-96% yields. The catalysts were also explored for the synthesis of pyranopyrazole derivatives from ethyl acetoacetate, 4-chlorobenzalydehyde, malononitrile and hydrazine hydrate in 43-96% yields.…”

Cucurbit[6]uril supported β-Ni(OH)2 nanoparticles as a heterogeneous catalyst for the synthesis of quinazolines via acceptorless dehydrogenative coupling of alcohols with nitriles

“…In the past decade, several synthetic methodologies have been developed for the synthesis of quinazolines due to its increasing importance in the field of medicinal chemistry (Scheme 1). [3][4][5][6][7][8][9][10][11] Despite these advancements, the synthetic approaches are fraught with several limitations such as the involvement of a multistep reaction procedure, requirement of pre-functionalized starting materials and stoichiometric amounts of oxidants, and generation of toxic wastes. [12][13][14][15] Therefore, there is a pursuit for the development of efficient, green, atom-economic methods using easily available and inexpensive starting materials for the synthesis of quinazolines.…”