In Situ Fabrication of Robust Polyphenolic Hydrogels for Skin Protection and Repair

Abstract

Robust and multifunctional polyphenolic hydrogels have been well acknowledged as promising biomaterial candidates due to their various fascinating properties in regulating cell biology. However, the construction of these hydrogels commonly needs multistep fabrication and a sophisticated gelation process. The typical phenol-aldehyde condensation is a facial and in situ reaction for industrial resin construction; however, its application in hydrogel fabrication is seldom reported. In this study, we reported the feasibility and modularity of this strategy for in situ fabricating various kinds of robust and multifunctional natural polyphenolic hydrogels using natural polyphenol (extracts) and formaldehyde. The physicochemical characterization results demonstrated that the chemical structure (e.g., phenolic hydroxyl groups) of polyphenol molecules could be well maintained after the gelation process, allowing as-prepared hydrogels to inherit the merits of polyphenol molecules, such as good UV shielding, radical scavenging, antibacterial properties, and so forth, as demonstrated by in vitro data. The in vitro and in vivo cellular and animal results further confirmed that the as-prepared hydrogels were able to perform a skin protection and repair role, as demonstrated in UV protection and wound healing models. Collectively, this strategy could allow natural polyphenols as both structural and functional synthons toward more types of robust hydrogels for a wide range of biomedical applications.

Optimization and Characterization of a Novel Antioxidant Naringenin-Loaded Hydrogel for Encouraging Re-Epithelization in Chronic Diabetic Wounds: A Preclinical Study

“…In the case of the blank and drug-encapsulated hydrogel group, a granulating layer was seen. The development of the granulating layer is evidenced that the drug-loaded hydrogel offered antioxidant action and reduction in inflammation, thereby providing a more favorable environment for healing. − …”

Robust and Multifunctional Therapeutic Nanoparticles against Peritonitis-Induced Sepsis

“…A DPPH free radical scavenging test was also carried out to investigate the radical scavenging capacity of PMB and NPs at various concentrations . In detail, a fresh DPPH solution (0.1 mM) was made by completely dissolving in ethanol.…”

“…A DPPH free radical scavenging test was also carried out to investigate the radical scavenging capacity of PMB and NPs at various concentrations. 31 In detail, a fresh DPPH solution (0.1 mM) was made by completely dissolving in ethanol. Then, the DPPH solution and samples were combined in a tube, and the mixture was left to sit in the dark for incubation.…”

Polyphenolic Platform Ameliorated Sanshool for Skin Photoprotection

“…[ 19 ] They could interact with each other or other functional molecules through hydrogen bonding, electrostatic interactions, and polymerization, enabling them to serve as both functors and synthons. [ 20 , 21 , 22 , 23 ] Based on the structural and functional properties, natural polyphenols‐based materials have been fabricated and applied to address key challenges in numerous fields. [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ] Notably, it could also serve as an effective platform to boost the key properties of functional materials based on the features of both structures and functions.…”