<i>In Situ</i> Generation of ZnO Nanoparticles within a Polyethyleneimine Matrix for Antibacterial Zein Fibers

Mascia, L.; Zhang, Wanwei; Gatto, Francesca; Scarpellini, Alice; Pompa, Pier Paolo; Mele, Elisa

doi:10.1021/acsapm.9b00276

Cited by 18 publications

(11 citation statements)

References 50 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It should be noted that the occurrence of antiplasticization has been revealed with respect to mechanical properties of electrospun fibre mats produced from zein mixtures with glycerol as the plasticizer. Moreover, in a recent report Mascia et al [165] have widened the horizon for the use of plasticizers in the electrospinning of zein fibres in a manner that could provide new opportunities for exploring the concept of antiplasticization to produce antibacterial fibre mats.…”

Section: Main Features and Comments Referencesmentioning

confidence: 99%

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

et al. 2020

Self Cite

View full text Add to dashboard Cite

Antiplasticization of glassy polymers, arising from the addition of small amounts of plasticizer, was examined to highlight the developments that have taken place over the last few decades, aiming to fill gaps of knowledge in the large number of disjointed publications. The analysis includes the role of polymer/plasticizer molecular interactions and the conditions leading to the cross-over from antiplasticization to plasticization. This was based on molecular dynamics considerations of thermal transitions and related relaxation spectra, alongside the deviation of free volumes from the additivity rule. Useful insights were gained from an analysis of data on molecular glasses, including the implications of the glass fragility concept. The effects of molecular packing resulting from antiplasticization are also discussed in the context of physical ageing. These include considerations on the effects on mechanical properties and diffusion-controlled behaviour. Some peculiar features of antiplasticization regarding changes in Tg were probed and the effects of water were examined, both as a single component and in combination with other plasticizers to illustrate the role of intermolecular forces. The analysis has also brought to light the shortcomings of existing theories for disregarding the dual cross-over from antiplasticization to plasticization with respect to modulus variation with temperature and for not addressing failure related properties, such as yielding, crazing and fracture toughness.

show abstract

Section: Main Features and Comments Referencesmentioning

confidence: 99%

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Zein exhibits several attractive attributes as a printable material. Zein is biodegradable, edible, has been classified as “generally recognized as safe” by the U.S. Food and Drug Administration (FDA), and has been used in biomedical applications, such as coatings for pharmaceutical capsules, ,, fabrication of scaffolds for cell culture, and synthesis of nanoparticles, fibers, and membranes for controlled drug release.…”

Section: Introductionmentioning

confidence: 99%

Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

Negrete

Aceves-Colin

Rivera-Flores

et al. 2021

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

The use of three-dimensional (3D) printing for biomedical applications has expanded exponentially in recent years. However, the current portfolio of 3D printable inks is still limited. For instance, only few protein matrices have been explored as printing/bioprinting materials. Here, we introduce the use of zein, the primary constitutive protein in maize seeds, as a 3D printable material. Zein-based inks were prepared by dissolving commercial zein powder in ethanol with or without polyethylene glycol (PEG400) as a plasticizer. The rheological characteristics of our materials, studied during 21 days of aging/maturation, showed an increase in the apparent viscosity as a function of time in all formulations. The addition of PEG400 decreased the apparent viscosity. Inks with and without PEG400 and at different maturation times were tested for printability in a BioX bioprinter. We optimized the 3D printing parameters for each ink formulation in terms of extrusion pressure and linear printing velocity. Higher fidelity structures were obtained with inks that had maturation times of 10 to 14 days. We present different proof-of-concept experiments to demonstrate the versatility of the engineered zein inks for diverse biomedical applications. These include printing of complex and/or free-standing 3D structures, tablets for controlled drug release, and scaffolds for cell culture.

show abstract

“…Solutions of maize zein (Sigma Aldrich) were prepared at a concentration of 20% ( w / v ) in a 70% v/v ethanol solution in deionized water at room temperature [ 23 ]. Solutions of LBA (HPLC-grade obtained from Sigma-Aldrich) were prepared at a concentration of 20% ( w / v ) in deionized water.…”

Section: Methodsmentioning

confidence: 99%

An In-Vitro Evaluation of the Characteristics of Zein-Based Films for the Release of Lactobionic Acid and the Effects of Oleic Acid

et al. 2021

Self Cite

View full text Add to dashboard Cite

Lactobionic acid (LBA) is widely used in different industrial sectors owing to its biocompatibility characteristics as well as antioxidant and antimicrobial properties. In this study, mixtures of the protein zein with LBA and with the addition of oleic acid (OA) as a ternary system were investigated as drug delivery films for the release of LBA. The chosen combinations exploit the vast difference in water solubility between LBA and the other two components (zein and OA). DSC thermograms and dynamic mechanical spectra, alongside electron microscopy images, were used to describe the microstructural features of the films and were found to provide insights for the release of LBA from the two examined zein-based films immersed in an aqueous physiological solution. For both film systems, a burst release behavior was observed, followed by a rapid and total extraction of LBA. The required immersion time for the total extraction of LBA was greatly reduced when oleic acid was added to the precursor solution mixture for producing the films. The LBA released from the zein-based films was found to exhibit both the expected antioxidant properties as well as exerting bacteriostatic effects towards Escherichia coli and Staphylococcus epidermidis.

show abstract

In Situ Generation of ZnO Nanoparticles within a Polyethyleneimine Matrix for Antibacterial Zein Fibers

Cited by 18 publications

References 50 publications

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

Antiplasticization of Polymer Materials: Structural Aspects and Effects on Mechanical and Diffusion-Controlled Properties

Three-Dimensional Printing Using a Maize Protein: Zein-Based Inks in Biomedical Applications

An In-Vitro Evaluation of the Characteristics of Zein-Based Films for the Release of Lactobionic Acid and the Effects of Oleic Acid

Contact Info

Product

Resources

About