<i>In situ</i> glyco-nanostructure formulation <i>via</i> photo-polymerization induced self-assembly

Ferji, Khalid; Venturini, Pierre; Cleymand, Franck; Chassenieux, Christophe; Six, Jean‐Luc

doi:10.1039/c8py00346g

Cited by 64 publications

(84 citation statements)

References 37 publications

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“…On the other hand, most of the current RAFT PISA works are still focused on the morphology diagram by modulating the species of macroinitiator/stabilizer, core‐forming block, solvent, temperature, etc. Especially, the macroinitiator/stabilizer with narrow molecular weight distribution ( M w / M n ) and defined molecular weight are always required, and the effect of M w / M n on the RAFT PISA system is rarely a concern . Previously, Armes et al compared the effect of DP of macroinitiator/stabilizer poly(lauryl methacrylate) (PLMA) chain transfer agents (CTAs) on the morphology diagram of poly(lauryl methacrylate‐benzyl methacrylate) (PLMA‐PB n MA) diblock copolymer nanoparticles, and different morphologies were actually captured in RAFT PISA system.…”

Section: Methodsmentioning

confidence: 99%

ICAR ATRP Polymerization‐Induced Self‐Assembly Using a Mixture of Macroinitiator/Stabilizer with Different Molecular Weights

Cao

Zhang

Wang

et al. 2019

Macromol. Rapid Commun.

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polymer bearing dual functions of macroinitiator and stabilizer, PISA can be realized by simultaneous polymerization and self-assembly procedures. [7][8][9] In a typical PISA procedure, the core-forming block is gradually extended and becomes insoluble with the conversion of monomer, and the formed block copolymer tends to be aggregated as various morphologies, such as spheres, worms, lamellae, vesicles, and so on. [10,11] Superior to the traditional postpolymerization self-assembly technique performed with highly diluted concentration (<1% w/w) and complicated operation procedures, the PISA technique features higher solid content (up to 50%) and simpler operation procedure. [5,6] The PISA technique has essentially accelerated the theoretical study and practical applications of self-assembled nanoparticles, and thus, is attracting more and more attention from researchers.On the one hand, most of the current PISA works are still based on the reversible addition-fragmentation chain transfer (RAFT) polymerization mechanism. [12][13][14][15][16][17][18][19][20][21][22][23][24] Relatively, nitroxide mediated polymerization (NMP), [25][26][27][28] atom transfer radical polymerization (ATRP), [29][30][31] living anionic polymerization, [32] and ring-opening metathesis polymerization (ROMP) [33] mechanisms are rarely involved in the PISA system. The reason can be attributed to some unavoidable drawbacks of each polymerization mechanism. For example, due to the intrinsic color question brought by copper catalyst, the normal ATRP PISA was originally attempted and later stagnated. [29][30][31]34,35] Fortunately, with the continuous optimization and improvement of the ATRP mechanism, the ATRP PISA was revived and greatly developed in recent years. For example, in our previous work, [36] the ppm copper catalyst system of initiators for continuous activator regeneration (ICAR) ATRP was successfully introduced into PISA using poly[oligo(ethylene oxide) methyl ether methacrylate] (POEOMA) (labeled as POEOMA 50 , 50 representing the degree of polymerization [DP]) as macroinitiator/stabilizer, poly(benzyl methacrylate) (PBnMA) as core-forming block, and ethanol as solvent. This work confirms the practical feasibility of ATRP PISA and presents an alternative way to enrich the PISA system. [37][38][39][40][41][42] On the other hand, most of the current RAFT PISA works are still focused on the morphology diagram by modulating Polymerization-Induced Self-Assembly The poly[oligo(ethylene oxide) methyl ether methacrylate]s, POEOMA 24 and POEOMA 78 with average degree of polymerization (DP) of 24 and 78, respectively, are separately achieved by initiators for continuous activator regeneration (ICAR) atom transfer radical polymerization (ATRP) of OEOMA 300 monomer. The mixtures of [POEOMA 24 ] 0 /[POEOMA 78 ] 0 = 1/1, 2/1, or 4/1 are employed as macroinitiator/stabilizer to practice the ICAR ATRP polymerization-induced self-assembly (PISA) of benzyl methacrylate (BnMA) at 65 °C. When the obtained dispersions are sequentially cooled to roo...

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Section: Methodsmentioning

confidence: 99%

ICAR ATRP Polymerization‐Induced Self‐Assembly Using a Mixture of Macroinitiator/Stabilizer with Different Molecular Weights

Cao

Zhang

Wang

et al. 2019

Macromol. Rapid Commun.

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“…In this context, we envisioned to use aqueous photo‐mediated RAFT (photo‐RAFT) polymerization that would be able to prepare well‐controlled UCST‐type copolymers directly in water at very high concentration. Although photo‐RAFT [ 28–33 ] has grasped great interests due to its versatility, rapidity, and ability to produce well‐controlled polymers, it has never been employed for the synthesis of UCST‐type polymers. This study provides new insight into UCST‐type copolymers and aims to develop facile approach to investigate such kind of thermoresponsive behavior, less described in the literature currently.…”

Section: Figurementioning

confidence: 99%

“…2‐(propylthiocarbonothioylthio)‐2‐methylpropionoic acid (TTC) (Figure 1) was used as a chain transfer agent (CTA) due to its ability to control the photo‐RAFT polymerization of acrylamide, [ 31 ] and its high stability under intense UV‐irradiation (365 nm) compared to other CTAs. [ 28,29,34 ] However, regarding its non‐solubility in water (pH = 7), a hydrophilic macromolecular chain transfer agent based on polyacrylamide (PAAm 24 ‐TTC) with very low molar mass ( M n = 1700 g mol −1 ) and low dispersity ( Đ = 1.04) was first prepared via RAFT polymerization of AAm in DMSO at 70 °C using TTC in the presence of 2,2′‐azobis(2‐methyl‐propionitrile) initiator (Figure 1; Figure S1, Supporting Information).…”

Section: Figurementioning

confidence: 99%

Synthesis of Thermoresponsive Copolymers with Tunable UCST‐Type Phase Transition Using Aqueous Photo‐RAFT Polymerization

Lertturongchai

Ibrahim

Durand

et al. 2020

Macromol. Rapid Commun.

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H-acceptor sites, which are able to form intra-molecular reversible hydrogen bonds (globule conformation below UCST) and inter-molecular bonds with water (coil conformation above UCST). [11][12][13][14][15][16][17][18][19][20][21] The non-ionic polymers have attracted a great deal of attention due to their insensitivity to salts, which make them more attractive for applications in physiological environment. [22][23][24] During the last decade, efforts have been focused toward developing novel water-soluble copolymers exhibiting UCST behavior by copolymerizing H-donor monomers (N-acryloyl glycinamide [11][12][13][14][15][16] or acrylamide [15,[17][18][19][20][21]25] ) and H-acceptor monomers (acrylonitrile, [11,15,18,19,21,25,26] styrene, [15,17] and butyl acrylate [15] ). Such (co)polymers have been mainly prepared using free radical polymerization [11,[14][15][16][17]26] and by thermally initiated controlled radical polymerization such as atom transfer radical polymerization [13] and reversible addition fragmentation chain transfer (RAFT) [11,12,[16][17][18][19]25] The impacts of various parameters on the UCST phase transition, including salts, pH, molecular weight, molecular weight distribution, and chemical composition, have been well evaluated. [7][8][9]25,27] However, such studies were carried out at low polymer concentrations (below 5 wt%). This could induce, an unintentional confusion between the UCST and the apparent cloud point temperature (T CP ), which refers to the temperature at which the phase transition occurs depending on the investigated concentration level. The UCST of a given polymer in solution is obtained from an isobaric phase diagram where T CP are plotted versus the polymer concentrations. [7][8][9] T CP should increase with the polymer concentrations up to a maximum temperature, called UCST, before going down again.In this context, we envisioned to use aqueous photo-mediated RAFT (photo-RAFT) polymerization that would be able to prepare well-controlled UCST-type copolymers directly in water at very high concentration. Although photo-RAFT [28][29][30][31][32][33] has grasped great interests due to its versatility, rapidity, and ability to produce well-controlled polymers, it has never been employed for the synthesis of UCST-type polymers. This study provides new insight into UCST-type copolymers and aims to develop facile approach to investigate such kind of thermoresponsive behavior, less described in the literature currently.

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“…They also enhance drug bioavailability at effective doses that were previously difficult to achieve. Studies have shown that both nanoparticle geometry and size play important roles in drug delivery [ 18 , 19 ]. Nanoparticle geometry could significantly affect the rate of drug loading and drug transport, and the balance between the size and geometry is critical to the efficiency of drug delivery.…”

Section: Introductionmentioning

confidence: 99%

Chitosan-Based Nanomaterials for Drug Delivery

et al. 2018

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This review discusses different forms of nanomaterials generated from chitosan and its derivatives for controlled drug delivery. Nanomaterials are drug carriers with multiple features, including target delivery triggered by environmental, pH, thermal responses, enhanced biocompatibility, and the ability to cross the blood-brain barrier. Chitosan (CS), a natural polysaccharide largely obtained from marine crustaceans, is a promising drug delivery vector for therapeutics and diagnostics, owing to its biocompatibility, biodegradability, low toxicity, and structural variability. This review describes various approaches to obtain novel CS derivatives, including their distinct advantages, as well as different forms of nanomaterials recently developed from CS. The advanced applications of CS-based nanomaterials are presented here in terms of their specific functions. Recent studies have proven that nanotechnology combined with CS and its derivatives could potentially circumvent obstacles in the transport of drugs thereby improving the drug efficacy. CS-based nanomaterials have been shown to be highly effective in targeted drug therapy.

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In situ glyco-nanostructure formulation via photo-polymerization induced self-assembly

Abstract: A broad set of advanced glyco-nanostructures, rarely obtained as vesicles or never reported as wormlike micelles, is obtained using photo-initiated Polymerization-Induced Self-Assembly (Photo-PISA).

Cited by 64 publications

References 37 publications

ICAR ATRP Polymerization‐Induced Self‐Assembly Using a Mixture of Macroinitiator/Stabilizer with Different Molecular Weights

ICAR ATRP Polymerization‐Induced Self‐Assembly Using a Mixture of Macroinitiator/Stabilizer with Different Molecular Weights

Synthesis of Thermoresponsive Copolymers with Tunable UCST‐Type Phase Transition Using Aqueous Photo‐RAFT Polymerization

Chitosan-Based Nanomaterials for Drug Delivery

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