In situ injectable NIR-responsive supramolecular hydrogels encapsulating ROS-triggered chain-breakage prodrug micelles and hydrophilic Fe₃O₄ nanoparticles for enhanced synergistic chemo-photothermal therapy

Abstract

Efficient synergistic therapeutic strategies for tumors with high specificity and sensitivity remain a major challenge. An injectable near-infrared (NIR)-responsive supramolecular hydrogel was prepared via host-guest interaction from conjugated poly(N-phenylglycine)- poly(ethylene...

Engineered cyclodextrin-based supramolecular hydrogels for biomedical applications

“…5C). 130 The drug-loaded nanomicelles were self-assembled by the amphiphilic precursors mPEG-TK-DOX linked via TK bonds. The PEG/PEI@Fe 3 O 4 nanoparticles in this hydrogel could utilize the Fenton reaction to generate ˙OH, which led to an increase of ROS and induced the breakage of the ROS-responsive TK bond, thereby promoting sustained DOX release.…”

“…10 Currently pH-responsive bonds such as imine bonds and acylhydrazone bonds, redox-responsive bonds including disulfide bonds and thioketal bonds, as well as enzyme-responsive bonds, have been extensively utilized for covalently modifying drugs on hydrogels. 123,130,147–149 These modified drug-loaded hydrogels exhibit more precise on-demand drug release and higher therapeutic efficiency compared to physically embedded drug-loaded hydrogels. For instance, Ha et al developed amphiphilic prodrugs by conjugating podophyllotoxin with PEG and self-assembled them to form nanomicelles.…”

Reactive oxygen species-responsive supramolecular deucravacitinib self-assembly polymer micelles alleviate psoriatic skin inflammation by reducing mitochondrial oxidative stress

“…Such polymerization usually relies on non-covalent interactions such as pi-pi stacking, hydrophobic interactions, etc. The process of SPMs are achieved by the adjustable solution pH (27), stimulus responsiveness or ionic strength (28)(29)(30).…”

A pH-responsive supramolecular hydrogel encapsulating a CuMnS nanoenzyme catalyst for synergistic photothermal–photodynamic–chemodynamic therapy of tumours

“…[39][40][41][42][43][44][45][46] a-Cyclodextrins (a-CDs) have a cavity structure that can be strung on single-chain poly(ethylene glycol) (PEG) by host-guest interaction to form pseudopolyrotaxanes (PPRs) in aqueous solution, and the presence of hydrogen bonding between adjacent PPRs leads to microcrystal aggregation, which induces physical cross-linking to form hydrogels. 47,48 The construction of PEG-based prodrug micelles into the hydrogel backbone can circumvent the problem of drug insolubility in water while avoiding premature drug leakage from the hydrogel, making it an attractive drug delivery platform.…”