In situ investigation of detoxification and metabolic effects of polyfluoroalkyl substances on metal–organic frameworks combined with cell-cultured microfluidics

Abstract

Over 9000 types of Per- and polyfluoroalkyl substances (PFASs) have been produced with environmentally persistent, bioaccumulation and biotoxicity, posing a potential hazard to human health. Metal-Organic Frameworks (MOFs) are structure-based...

Microfluidic Chip-Based Modeling of Three-Dimensional Intestine–Vessel–Liver Interactions in Fluorotelomer Alcohol Biotransformation

“…A growing number of epidemiological and laboratory investigations have identified a range of adverse effects of PFAS exposure on human health. These include vascular toxicity, hepatotoxicity, endocrine and immune disruption, and reproductive toxicity. − Several studies have indicated that PFAS can also accumulate in other tissue compartments besides blood, such as the liver and intestines. − This is because they are secreted by the liver through bile into the intestines, and some of them are reabsorbed into the bloodstream and transported back to the liver via enterohepatic circulation. , The hepatic-intestinal circulation is believed to have a significant impact on the bioaccumulation, transportation, and dynamic redistribution of PFAS between different tissues . Therefore, studying intestine–vessel–liver interactions in PFAS bioaccumulation will yield valuable insights for assessing the toxicity of PFAS.…”