In‐situ lobular/myoepithelial neoplasia of the breast

Abstract

the relative radiolucency of the centre of the mass. Neoadjuvant therapy also rendered the cells less immunoreactive for CK20 and CEA with eosinophilic cytoplasmic transformation and a reduction of glandular structures. There was a remarkable reduction of proliferative activity. As a result there was a scant number of tumour cells having eosinophilic cytoplasm making malignancy difficult to identify in the colon and especially in metastatic sites due to these atypical features of the tumour cells as well as the change in their immunohistochemical properties.

Lobular Carcinoma of the Breast With Hybrid Myoepithelial and Secretory (???Myosecretory???) Cell Differentiation

“…The in situ part of the 3 cases displayed three different types of cells, as evidenced by hematoxylin and eosin and/or immunohistochemistry. This immunohistochemical phenotype is similar to that seen in normal myoepithelial cells and myoepithelial cell neoplasms 9,10 and to those seen in the cases of intralobular growth of myoepithelial cell carcinoma reported by Soares et al, 15 by Shousha and Knee, 13 and in the case of intraductal myoepithelioma described by Tamai. 16 The second phenotype observed in some parts of the intralobular proliferations of case nos.…”

“…All the same markers were lacking in the cells of the central part of the same acinus as well as in those present in the other expanded acini (Figs. 12,13). Only EMA, ER, and PR were consistently positive.…”

“…Soares et al 15 described 2 cases showing intralobular neoplastic myoepithelial cells and, more recently, another case of in situ lobular neoplasia containing myoepithelial cells was documented. 13 Tamai 16 has reported the only case of intraductal carcinoma with myoepithelial cell differentiation.…”

Cribriform Adenocarcinoma of the Tongue and Minor Salivary Glands: A Review

“…These cells displayed not only the typical lobular cytomorphology, but also myoepithelial differentiation as shown by several myoepithelial markers. Although there are reports of additional mammary adenocarcinomas exhibiting similar hybrid secretory and myoepithelial differentiation [10][11][12] the presence of these cells in CAT-MSG has never been described in other salivary gland neoplasms and seems to be unique.…”

Adenomyoepithelioma of the breast: a review stressing its propensity for malignant transformation

“…AMEs are rarely encountered in routine surgical pathology practice and apart from the comprehensive writings of Tavassoli, Rosen and Page, most of the literature consists of individual case reports or studies of less than five cases 7 14–17. These neoplasms are different from myosecretory carcinoma, a neoplasm that shows hybrid secretory and myoepithelial features within individual tumour cells rather than distinctly separate ductal and myoepithelial clones 18 19…”