In situ photocrosslinkable hyaluronic acid‐based surgical glue with tunable mechanical properties and high adhesive strength

Abstract

Hyaluronic acid (HA), a naturally occurring linear polysaccharide, has been widely used as a key biomaterial in a range of cosmetic and therapeutic applications. Its excellent biocompatibility and bio-functions related to tissue regeneration encourage the development of HA-based hydrogels to expand its applications. This study details an in situ forming surgical glue based on photocrosslinkable HA, providing tunable mechanical properties and firm tissue adhesion under wet and dynamic conditions. Depending on the degree of photocrosslinkable methacrylate groups in HA polymer chains, the mechanical properties of hyaluronate methacrylate (HAMA) hydrogels prepared by UV photocrosslinking was improved. Ex vivo adhesion tests revealed that HAMA hydrogels exhibited 3-fold higher shear adhesive strength compared to gelatin methacryloyl hydrogels and achieved firm adherence to the porcine skin tissue for several weeks. The high adhesive strength of HAMA hydrogels, under dry and wet conditions, suggests that it may have great promise as a tissue adhesive.Additional supporting information may be found in the online version of this article.

Engineering a naturally-derived adhesive and conductive cardiopatch

“…Wound closure tests were performed using a modified ASTM F2458-05 to determine the adhesive strength based on the previously explained procedures [38,50,82]. Porcine skin and rat myocardium wet tissues were used as substrates.…”

Recent progress in polymer hydrogel bioadhesives

“…Polymer hydrogels with tissue‐like highly hydrated network structures are ideal candidates for surgical sealants and wound dressings 4 . Polymer hydrogels with multiple functional groups can form covalent bonding or non‐covalent attractions to tissue surfaces.…”

Adhesive Tissue Engineered Scaffolds: Mechanisms and Applications

“…A variety of mechanical tests such as tensile strength, shearing strength, burst pressure, wound closure, and peeling adhesion tests are primarily used to probe adhesive strength of biomaterials (Figure 2; Shin et al, 2015). Tensile test is employed when the adhesive scaffold is used to provide a linkage, such as in nerve repairing implants (Muzhou et al, 2012;Assmann et al, 2017;Xin et al, 2017;Jouan and Constantinescu, 2018;Chandrasekharan et al, 2019;Hong et al, 2019;Yuk et al, 2019;Cadena et al, 2020). Tensile test to measure adhesive properties is conducted by attaching the scaffold between the target tissues that are connected to the two probes of a tensile tester.…”