<i>In situ</i> preparation of hydroxyapatite in lamellar liquid crystals for joint lubrication and drug delivery

Fan, Lei; Song, Chao; Lu, Ximing; Wang, Tong; Han, Jie; Guo, Rong

doi:10.1039/d2sm01105k

Cited by 5 publications

(1 citation statement)

References 48 publications

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“…Various desired drugs could be directly infused in the porous HAp or surface modified HAp nanoparticle systems, and then could be utilized for targeted delivery as well as for strengthening the nascent bone tissue structure [ 150 – 153 ]. These drug-loaded vehicles could be used in drug delivery applications for the bone-damage causing diseases such as osteoporosis and tumors [ 154 – 156 ]. Several recent reports also detailed the effective practice of using nano HAp functionalized with bioactive factors or organic polymers for targeted and controlled drug delivery, with better biodegradability, non-toxicity as well as increased drug loading capacity [ 157 – 159 ].…”

Section: Inorganic and Organic Nanoparticlesmentioning

confidence: 99%

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

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The nanosystems for delivering drugs which have evolved with time, are being designed for greater drug efficiency and lesser side-effects, and are also complemented by the advancement of numerous innovative materials. In comparison to the organic nanoparticles, the inorganic nanoparticles are stable, have a wide range of physicochemical, mechanical, magnetic, and optical characteristics, and also have the capability to get modified using some ligands to enrich their attraction towards the molecules at the target site, which makes them appealing for bio-imaging and drug delivery applications. One of the strong benefits of using the inorganic nanoparticles-drug conjugate is the possibility of delivering the drugs to the affected cells locally, thus reducing the side-effects like cytotoxicity, and facilitating a higher efficacy of the therapeutic drug. This review features the direct and indirect effects of such inorganic nanoparticles like gold, silver, graphene-based, hydroxyapatite, iron oxide, ZnO, and CeO2 nanoparticles in developing effective drug carrier systems. This article has remarked the peculiarities of these nanoparticle-based systems in pulmonary, ocular, wound healing, and antibacterial drug deliveries as well as in delivering drugs across Blood–Brain-Barrier (BBB) and acting as agents for cancer theranostics. Additionally, the article sheds light on the plausible modifications that can be carried out on the inorganic nanoparticles, from a researcher’s perspective, which could open a new pathway. Graphical abstract

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Section: Inorganic and Organic Nanoparticlesmentioning

confidence: 99%

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Unnikrishnan,

Joy,

Megha

et al. 2023

Discover Nano

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Brij30/[C10mim]Br/H2O lamellar liquid crystals for enhanced lubrication and conductivity properties

Song,

Hu,

Liu

et al. 2025

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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Targeted non-invasive Metformin-Curcumin co-loaded nanohyaluosomes halt osteoarthritis progression and improve articular cartilage structure: A preclinical study

El-Haddad,

El-Refaie,

Hammad

et al. 2024

International Journal of Pharmaceutics

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In situ preparation of hydroxyapatite in lamellar liquid crystals for joint lubrication and drug delivery

Abstract: Arthritis is a disease that seriously affects the quality of human life, which is partly caused by the reduction of joint lubrication performance. Thus, for the treatment of arthritis treatment,...

Cited by 5 publications

References 48 publications

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Exploration of inorganic nanoparticles for revolutionary drug delivery applications: a critical review

Brij30/[C10mim]Br/H2O lamellar liquid crystals for enhanced lubrication and conductivity properties

Targeted non-invasive Metformin-Curcumin co-loaded nanohyaluosomes halt osteoarthritis progression and improve articular cartilage structure: A preclinical study

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