In situ pressure measurement within deformable rectangular polydimethylsiloxane microfluidic devices

Abstract

In this paper, we present a simple procedure to incorporate commercially available external pressure transducers into existing microfluidic devices, to monitor pressure-drop in real-time, with minimal design modifications to pre-existing channel designs. We focus on the detailed fabrication steps and assembly to make the process straightforward and robust. The work presented here will benefit those interested in adding pressure drop measurements in polydimethylsiloxane (PDMS) based microchannels without having to modify existing channel designs or requiring additional fabrication steps. By using three different devices with varying aspect ratio channels (wh0, width/depth), we demonstrate that our approach can easily be adapted into existing channel designs inexpensively. Furthermore, our approach can achieve steady state measurements within a matter of minutes (depending on the fluid) and can easily be used to investigate dynamic pressure drops. In order to validate the accuracy of the measured pressure drops within the three different aspect ratio devices, we compared measured pressure drops of de-ionized water and a 50 wt. % glycerol aqueous solution to four different theoretical expressions. Due to the deformability of PDMS, measured pressure drops were smaller than those predicted by the rigid channel theories (plate and rectangular). Modification of the rigid channel theories with a deformability parameter α provided better fits to the measured data. The elastic rectangular expression developed in this paper does not have a geometric restriction and is better suited for microchannels with a wider range of aspect ratios.

Static response of deformable microchannels: a comparative modelling study

“…For example, the relationship between the pressure drop and the flow rate (a key relationship needed for the design and operation of any fluidic system) in a deformable microchannel remains a topic of vigorous experimental investigation [9,10,11,12,13,14]. However, each new study comes with its own theoretical model, which is sometimes of limited applicability.…”

Droplet generation in a microchannel with a controllable deformable wall

“…In order to avoid the possibility of oil-air interface inside the capillary, the capillaries connecting the pressure taps on the device and the pressure sensor were primed carefully. We have used the similar protocol followed by Cheung et al (2012) to interface the pressure sensor with the pressure tappings and perform the experiments with the pressure sensor. An inverted microscope (Axiovert A1) coupled with a high speed camera (FASTCAM SA3, Photron Inc., USA) and fluorescent attachment (HBO 100 illuminator, Carl Zeiss, Germany) interfaced with PC via software (Photron Fastcam Viewer 3) was used to capture the images.…”

Deformation properties between fluid and periodic circular obstacles in polydimethylsiloxane microchannels: Experimental and numerical investigations under various conditions

“…Also, scaling analysis has been widely used when the applied flow rates are relatively high. The relative equation for the maximum thickness variation of a microchannel at any given position can be described as 22,23,35 FIG. 4.…”