<i>In vitro</i>activities of fluconazole, itraconazole and voriconazole against otomycotic fungal pathogens

Yenişehirli, Gülgün; Bulut, Yunus Emre; Güven, Mehmet Emrah; Günday, Ebru

doi:10.1017/s0022215109005489

Cited by 19 publications

(9 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antifungal susceptibility data indicate that there are no significant differences in the susceptibilities of A. niger and A. awamori to either of the antifungal tested (Table 2). All isolates were resistant to fluconazole; this is in agreement with previous findings 24 . On the other hand, all isolates were found to be highly susceptible to terbinafine.…”

Section: Discussionsupporting

confidence: 92%

See 1 more Smart Citation

Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran

Szigeti

Sedaghati

Mahmoudabadi

et al. 2011

Mycoses

View full text Add to dashboard Cite

Black aspergilli are among the main causative agents of otomycosis worldwide. In this study, the species assignment of black aspergilli isolated from otomycosis cases in Iran was carried out using sequence analysis of part of the calmodulin gene. The results indicate that Aspergillus niger is not the only black Aspergillus species involved in otomycosis cases in Iran: Aspergillus awamori and Aspergillus tubingensis are also able to cause ear infections. Antifungal susceptibility tests were carried out against five antifungal drugs including amphotericin B, fluconazole, itraconazole, ketoconazole and terbinafine. All isolates were highly susceptible to terbinafine, while they exhibited moderate susceptibilities against amphotericin B, fluconazole and ketoconazole. Aspergillus niger and A. awamori were found to have higher minimal inhibitory concentrations for azoles than A. tubingensis, in accordance with previous findings.

show abstract

Section: Discussionsupporting

confidence: 92%

“…All isolates were resistant to fluconazole; this is in agreement with previous findings. 24 On the other hand, all isolates were found to be highly susceptible to terbinafine. Previous studies also indicated that black aspergilli are relatively susceptible to this antifungal drug.…”

Section: Discussionmentioning

confidence: 96%

Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran

Szigeti

Sedaghati

Mahmoudabadi

et al. 2011

Mycoses

View full text Add to dashboard Cite

show abstract

“…The most common fungi reported in these infections are species from the genus Aspergillus , frequently A. niger and A. fumigatus although other moulds have been implicated 28,31–33 …”

Section: Discussionmentioning

confidence: 99%

Chronic monolateral otomycosis in a dog caused by Aspergillus ochraceus

Ghibaudo

Peano

2010

Veterinary Dermatology

View full text Add to dashboard Cite

Aspergillus ochraceus, a widely distributed filamentous fungus, was isolated and identified by cytology and culture as the cause of unilateral ceruminous purulent otitis in a 4-year-old male mixed-breed dog. The pathogenic role of the fungal isolate was confirmed by a good response to antifungal therapy and the absence of other pathogens. No underlying diseases were identified and the dog recovered after 3 weeks of therapy with oral itraconazole and topical miconazole.

show abstract

“…No pediatric randomized trial has assessed the outcome of cardiac and CNS infections treated with voriconazole. Some studies have reported the successful outcome of IA management with voriconazole in the pediatric age group ( 17 ). Our patient was successfully treated with combination therapy (i.e., surgery and IV liposomal amphotericin B followed by four weeks of oral voriconazole).…”

Section: Discussionmentioning

confidence: 99%

Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome

Fattahi¹,

Sayyahfar²,

Lotfali³

et al. 2021

CMM

View full text Add to dashboard Cite

Background and Purpose: Aspergillus species are implicated as the etiology of approximately 26% of endocarditis cases. Central nervous system aspergillosis is a life-threatening condition that has a mortality rate of 80%. Case report: Herein, we report a four– year- old female who was admitted to the pediatric infectious ward due to a fever of unknown origin in January 2020. She was a known case of Marfan syndrome with a family history of this syndrome in her mother. The species was identified using (PCR) and the antifungal susceptibility test was performed using four antifungal agents based on the Clinical and Laboratory Standards Institute M38 3rd edition. Fluconazole-resistant Aspergillus flavus was identified to be responsible for endocarditis and meningitis as well as fever of unknown origin. Conclusion: The clinicians should be aware and consider fungal endocarditis in blood culture-negative endocarditis even in patients with no significant risk factor when antibiotic therapy fails.

show abstract

In vitroactivities of fluconazole, itraconazole and voriconazole against otomycotic fungal pathogens

Abstract: This study found that the most common otomycotic fungal pathogen was A fumigatus, and that voriconazole had more potent in vitro activity than itraconazole against all Aspergillus species as well as against C albicans.

Cited by 19 publications

References 20 publications

Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran

Species assignment and antifungal susceptibilities of black aspergilli recovered from otomycosis cases in Iran

Chronic monolateral otomycosis in a dog caused by Aspergillus ochraceus

Aspergillus flavus endocarditis and meningitis in a child with marfan syndrome

Contact Info

Product

Resources

About