In vitro activity of an essential oil against Leishmania donovani

Abstract

The in vitro antileishmanial effect of the essential oil from Chenopodium ambrosioides against Leishmania donovani was investigated. The product showed significant activity against promastigotes and amastigotes, with a 50% effective concentration of 4.45 and 5.1 microg/mL, respectively. The essential oil caused an irreversible inhibition of the growth of promastigotes after a treatment with 100 or 10 microg/mL for 1 or 24 h, respectively. The phagocytic activity of the macrophages was preserved at a concentration toxic to the parasite. The essential oil from C. ambrosioides may be a potential candidate drug to development a new agent to combat this parasitic disease.

Potential of Herbal Drug and Antibiotic Combination Therapy: A New Approach to Treat Multidrug Resistant Bacteria

“…It plays an important role in pharmacological effects such as anti-inflammatory, antimicrobial, antioxidant, anti-diabetes, antispasmodic, antiulcer and cytotoxic properties [93]. It possesses antimicrobial activity also against protozoans [94] and viruses, with minimal mammalian toxicity [95].…”

Activity of Thymus capitellatus volatile extract, 1,8-cineole and borneol against Leishmania species

“…Comparing these with the present data, we see that T. capitellatus oil shows antileishmanial activity that is similar or higher than that described for the other essential oils on these three Old World species. Various essential oils were tested against Leishmania species of the New World: Leishmania amazonensis (IC 50 values from 1.7 to 135 g/ml) (Ueda-Nakamura et al, 2006; Monzote et al, 2006;Santin et al, 2009;Santos et al, 2010;Moura do Carmo et al, 2012); Leishmania braziliensis (IC 50 values from 52.1 to 204.36 g/ml) (Monzote et al, 2010;Sanchez-Suarez et al, 2013); L. chagasi (IC 50 values from 4.4 to 181 g/ml) (Oliveira et al, 2009;Escobar et al, 2010;Rondon et al, 2012); Leishmania donovani (IC 50 values from 4.45 to 156 g/ml) (Monzote et al, 2007(Monzote et al, , 2010Zheljazkov et al, 2008;Parreira et al, 2010); Leishmania guyanensis (IC 50 values from 15.2 to 315.55 g/ml) (Moura do Carmo et al, 2012;Sanchez-Suarez et al, 2013); Leishmania mexicana (IC 50 63.3 g/ml) (Monzote et al, 2010); Leishmania panamensis (IC 50 values from 42.23 to 427.95 g/ml) (Sanchez-Suarez et al, 2013). The oils showed variable levels of activity against Leishmania, which depended on the species used in the assays.…”

Inhibition of methicillin-resistant Staphylococcus aureus (MRSA) by antimicrobial peptides (AMPs) and plant essential oils

“…One possible approach is to determine whether bioactive compounds from natural products and traditional medicinal plants, which have strong bactericidal activity against MRSA, either show synergistic interaction with antibiotics or enhance the susceptibility level of resistant S. aureus to methicillin (Aiyegoro et al 2011). Thus, such peptides represent promising foundations for developing a new generation of antimicrobial agents (Wang 2010).The EOs usually possess antimicrobial activity not only against bacteria, but also against fungi (Tyagi & Malik 2010), protozoans (Monzote et al 2007) and viruses (Garozzo et al 2011) which is especially important in mixed infections. Furthermore, EOs also have antiinflammatory (Miguel 2010), immune modulatory (Sadlon & Lamson 2010), antioxidant (Miguel 2010;Serrano et al 2011) and regenerative activities, which make them promising agents in the treatment of different infections.…”

“…The EOs usually possess antimicrobial activity against bacteria, fungi, protozoans and viruses (Monzote et al 2007;Tyagi & Malik 2010;Garozzo et al 2011), which make them promising agents in the treatment of different infections including MRSA one.…”