In Vitro Activity of Rifampin, Rifabutin, and Rifapentine against Enterococci and Streptococci from Periprosthetic Joint Infection

Abstract

Rifampin is an antibiotic with antistaphylococcal biofilm activity used in the management of staphylococcal periprosthetic joint infection with irrigation and debridement with component retention; some patients are unable to receive rifampin due to drug interactions or intolerance. We recently showed rifabutin and rifapentine to have in vitro activity against planktonic and biofilm states of rifampin-susceptible periprosthetic joint infection-associated staphylococci.

Antimicrobial treatment of patients with a periprosthetic joint infection: basic principles

“…PJIs. Commonly, β-lactams and clindamycin are used for these infections, but they demonstrated limited in vitro activity against biofilm-embedded bacteria, while rifampicin showed better in vitro activity [ 26 – 29 ]. For both streptococcal and Cutibacterium spp .…”

Rifampicin in periprosthetic joint infections: where do we stand and where are we headed?

“…Ideally, randomized controlled trials should be performed also for other Gram positive microorganisms. Alternative drugs like rifabutin and rifapentin with less side effects and less drug-drug interactions need to be explored as they also show excellent antibiofilm properties for Gram positive microorganisms [54,55].…”