In vitro activity of taurolidine against clinical Candida auris isolates: relevance to catheter-related bloodstream infections

Abstract

Candida auris is an evolving and concerning global threat. Of particular concern are bloodstream infections related to central venous catheters. We evaluated the activity of taurolidine, a broad-spectrum antimicrobial in catheter lock solutions, against 106 C . auris isolates. Taurolidine was highly active with a MIC 50 /MIC 90 of 512/512 mg/L, over 20-fold lower than lock solution concentrations of ≥13,500 mg/L. Our data demonstrate a theoretical basis for taurolidine-based lock solutions for prevention of C. auris catheter-associated infections.