In vitro Amoebicidal Activity of Borage (Borago officinalis) Extract on Entamoeba histolytica

Leos-Rivas, Catalina; Verde-Star, María Julia; Torres, Lidia Teresa Osuna; Oranday-Cárdenas, Azucena; Rivas-Morales, Catalina; Barrón-González, M.P.; Morales-Vallarta, M.; Cruz-Vega, Delia Elva

doi:10.1089/jmf.2010.0164

Cited by 11 publications

(8 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A dose-response curve was observed for B. officinalis BF and WF plant material ( Figure 3 a,b) which exhibited IC 50 values of 0.49 and 0.28 mg·mL −1 respectively. This cytotoxic effect of borage was also found in the Vero line of African green monkey kidney cells with an IC 50 value of 0.2 mg·mL −1 (similar to that obtained for our borage WF samples) [ 61 ].…”

Section: Resultssupporting

confidence: 86%

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

et al. 2016

View full text Add to dashboard Cite

Nowadays, healthy eating is increasing the demand of functional foods by societies as sources of bioactive products with healthy qualities. For this reason, we tested the safety of the consumption of Borago officinalis L. and its main phenolic components as well as the possibility of its use as a nutraceutical plant to help in cancer prevention. The in vivo Drosophila Somatic Mutation and Recombination Test (SMART) and in vitro HL-60 human cell systems were performed, as well-recognized methods for testing genotoxicity/cytotoxicity of bioactive compounds and plant products. B. officinalis and the tested compounds possess antigenotoxic activity. Moreover, B. officinalis wild type cultivar exerts the most antigenotoxic values. Cytotoxic effect was probed for both cultivars with IC50 values of 0.49 and 0.28 mg·mL−1 for wild type and cultivated plants respectively, as well as their constituent rosmarinic acid and the assayed phenolic mixture (IC50 = 0.07 and 0.04 mM respectively). B. officinalis exerts DNA protection and anticarcinogenic effects as do its component rosmarinic acid and the mixture of the main phenolics presented in the plant. In conclusion, the results showed that B. officinalis may represent a high value plant for pleiotropic uses and support its consumption as a nutraceutical plant.

show abstract

Section: Resultssupporting

confidence: 86%

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Plants of the genus Borago are used in herbal medicinal products due its antihypertensive effect [174], amoebicidal activity to treat gastrointestinal diseases [175], and antioxidant and antimicrobial effects [176,177]. PAs determined in the different subtypes are listed in Table 2.…”

Section: Boragomentioning

confidence: 99%

Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review

Kopp

Abdel‐Tawab

Mizaikoff

2020

Toxins

View full text Add to dashboard Cite

Pyrrolizidine alkaloids (PAs) are distributed in plant families of Asteraceae, Boraginaceae, and Fabaceae and serve in the chemical defense mechanism against herbivores. However, they became a matter of concern due to their toxicity associated with the high risk of intake within herbal preparations, e.g., phytopharmaceutical formulations, medicinal teas, or other plant-derived drug products. In 1992, the German Federal Ministry of Health established the first limits of PA content for fourteen medicinal plants. Because of the toxic effects of PAs, the Federal Institute of Risk Assessment (BfR) established more stringent limits in 2011, whereby a daily intake <0.007 µg/kg body weight was recommended and valid until 2018. A threefold higher limit was then advised by BfR. To address consumer safety, there is the need for more efficient extraction procedures along with robust, selective, and sensitive analytical methods to address these concerns. With the increased prevalence of, e.g., phytopharmaceutical formulations, this timely review comprehensively focuses on the most relevant extraction and analysis strategies for each of those fourteen plant genera. While a variety of extraction procedures has been reported, differences in PA content of up to 1110 ppm (0.11% (w/w)) were obtained dependent on the nature of the solvent and the applied extraction technique. It is evident that the efficient extraction of PAs requires further improvements or at least standardization of the extraction conditions. Comparing the various analytical techniques applied regarding selectivity and sensitivity, LC-MS methods appear most suited. This review shows that both standardized extraction and sensitive determination of PAs is required for achieving appropriate safety levels concerning public health in future.

show abstract

“…The methanolic extract had an IC 50 of 203.9 μg/mL for vero cells and no toxic effect was observed on brine shrimp at any dose tested. [60] The toxicity was due to the harmful pyrrolizidine alkaloids present in leaves. Thus, the Botanical Safety Handbook of American Herbal Products Association (1997) recommended consuming these leaves discontinuously.…”

Section: Cytotoxicity Of B Officinalis Leavesmentioning

confidence: 99%

Borago Officinalis L.: A Review Oon Extraction, Phytochemical, and Pharmacological Activities

Slama,

Slougui,

Benaissa

et al. 2024

Chemistry & Biodiversity

View full text Add to dashboard Cite

Borago officinalis L., an annual herb belonging to the Boraginaceae family, is used in the traditional medical practices of various countries and for multiple treatments, including respiratory disorders, colds, influenza, diarrhea, cramps, inflammation, palpitation, hypertension menopause, and post‐menopausal symptoms. Its pharmacological properties and biological activities ‐ among them antioxidant, antimicrobial, anticancer, anti‐inflammatory, insecticidal, antigenotoxic, and anti‐obesity activity ‐ were demonstrated in vitro and in vivo and are related to its rich content of bioactive compounds (mainly phenolic acids, flavonoids, anthocyanins, alkaloids, and terpenes) extracted from various parts of B. officinalis including leaves, flowers, seeds, and roots. This review summarizes all updated information on applied extraction processes, phytochemistry, pharmacology, and toxicity of B. officinalis.

show abstract

In vitro Amoebicidal Activity of Borage (Borago officinalis) Extract on Entamoeba histolytica

Cited by 11 publications

References 16 publications

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

Cancer Prevention and Health Benefices of Traditionally Consumed Borago officinalis Plants

Extracting and Analyzing Pyrrolizidine Alkaloids in Medicinal Plants: A Review

Borago Officinalis L.: A Review Oon Extraction, Phytochemical, and Pharmacological Activities

Contact Info

Product

Resources

About