<i>In vitro</i> &amp; <i>in vivo</i> evaluations of PLGA nanoparticle based combinatorial drug therapy for baclofen and lamotrigine for neuropathic pain management

Nigam, Kuldeep; Kaur, Atinderpal; Tyagi, Amit; Manda, Kailash; Goswami, Nidhi; Nematullah, Md; Khan, Farah; Gabrani, Reema; Gauba, Pammi; Dang, Shweta

doi:10.1080/02652048.2022.2041751

Cited by 4 publications

(1 citation statement)

References 52 publications

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“…When they were co-encapsulated in PLGA, repeated use of the drug was avoided, significantly reducing the peripheral organ toxicity that may occur with repeated doses of lamotrigine alone. In vivo studies showed that this delivery combination reached the brain and stayed there for a longer time, with potential effects on inflammatory pain [ 64 ].…”

Section: Drug Combination-based Drug Delivery Systems For Pain Treatmentmentioning

confidence: 99%

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

Xu,

Dong,

et al. 2023

Pharmaceutics

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The use of nanomaterials in drug delivery systems for pain treatment is becoming increasingly common. This review aims to summarize how nanomaterial-based drug delivery systems can be used to effectively treat and relieve pain, whether via the delivery of a single drug or a combination of multiple therapeutics. By utilizing nanoformulations, the solubility of analgesics can be increased. Meanwhile, controlled drug release and targeted delivery can be realized. These not only improve the pharmacokinetics and biodistribution of analgesics but also lead to improved pain relief effects with fewer side effects. Additionally, combination therapy is frequently applied to anesthesia and analgesia. The co-encapsulation of multiple therapeutics into a single nanoformulation for drug co-delivery has garnered significant interest. Numerous approaches using nanoformulation-based combination therapy have been developed and evaluated for pain management. These methods offer prolonged analgesic effects and reduced administration frequency by harnessing the synergy and co-action of multiple targets. However, it is important to note that these nanomaterial-based pain treatment methods are still in the exploratory stage and require further research to be effectively translated into clinical practice.

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Section: Drug Combination-based Drug Delivery Systems For Pain Treatmentmentioning

confidence: 99%

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

Xu,

Dong,

et al. 2023

Pharmaceutics

View full text Add to dashboard Cite

show abstract

Preparation and optimization of agarose or polyacrylamide/amino acid-based double network hydrogels for photocontrolled drug release

Xiang,

Guilbaud-Chéreau,

Hoschtettler

et al. 2024

International Journal of Biological Macromolecules

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Lamotrigine derivatives‐synthesis, anti‐cancer, and anti‐MDR‐bacterial activities

Khan

Siddiqui

Sharif

et al. 2022

Journal of Molecular Structure

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In vitro & in vivo evaluations of PLGA nanoparticle based combinatorial drug therapy for baclofen and lamotrigine for neuropathic pain management

Cited by 4 publications

References 52 publications

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

Preparation and optimization of agarose or polyacrylamide/amino acid-based double network hydrogels for photocontrolled drug release

Lamotrigine derivatives‐synthesis, anti‐cancer, and anti‐MDR‐bacterial activities

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