Background: Although stainless steel crowns (SSCs) on permanent molars are a common interim full-coverage restoration, there are few clinical studies on longevity. Aim: To evaluate the longevity of SSCs as restorations on young permanent first molars (PFMs) that have undergone vital pulp therapy (VPT) treatment and to identify factors associated with SSC treatment failure. Design: This study conducted a retrospective chart review of children who had PFMs that have undergone VPT treatment and been restored with SSCs. Data from treatment and follow-up visits were collected. The Kaplan-Meier survival analysis was used to analyse the longevity of SSCs. A multivariate Cox proportional hazards regression model was used to identify factors associated with SSC treatment failure. Results: Data from 140 SSCs were included, with an average follow-up period of 33.5 ± 21.6 (range, 6-104) months. Although none of the teeth had pulpal failure, 35.7% had SSC treatment failure. The survival probabilities of SSCs declined over time, reaching 39.6% (95% CI 27.0-51.9) after 60 months. The immediate postoperative condition of SSCs and the loss of proximal wall on the abutment tooth were significant factors associated with SSC treatment failure. Conclusion: Stainless steel crowns are suitable for use as interim restorations in PFMs that have undergone VPT treatment in children, but their longevity is limited, necessitating replacement over time. K E Y W O R D S children, permanent first molar, longevity, stainless steel crowns, vital pulp therapy How to cite this article: Chaipattanawan N, Chompu-inwai P, Nirunsittirat A, Phinyo P, Manmontri C. Longevity of stainless steel crowns as interim restorations on young permanent first molars that have undergone vital pulp therapy treatment in children and factors associated with their treatment failure: A retrospective study of up to 8.5 years.