<i>In vitro</i>and computational studies on the antiglycation activity of compounds isolated from antidiabetic<i>Tetracera alnifolia</i>stem bark

To make the distinction against pharmaceuticals, natural product medicines are more accurately denoted as nutritional therapies. In the context of topical therapies targeting dermatological conditions, nutritional therapy may explain the mechanism of ethnocosmetic plants used in hair treatment and care. Inspired by emerging theories of a connection between dysregulated glucose metabolism and hair loss, the current review of the literature focused on African plants used to target hair conditions in general, such as alopecia or scalp dermis infections, with a cross-examination of the potential of the species to alleviate issues with glucose metabolism. We distinguish between topical nutrition and sterilization (i.e., dandruff and lice). Sixty-eight plants were identified as an African treatment for alopecia, dandruff, lice, and tinea. Fifty-eight of the species have potential as antidiabetic treatments when taken orally. The family Lamiaceae was the most represented (six spp.), followed by Fabaceae and Asteraceae (five spp. each). Most species are herbs, and the most used plant part is the leaf. Thirty of the sixty species have research associated with hair growth and general hair care, with studies focused on 5α-reductase inhibition, biomarkers such as vascular endothelial growth factor, and the rate of telogen to anagen phase transition. While studies tend to conceptualize the mechanisms of these medicinal species similarly to pharmaceuticals, the current review argues that a nutritional interpretation is more appropriate, where a general improvement to local glucose metabolism may play a role.

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Flavonoid from Moringa oleifera leaves revisited: A review article on in vitro, in vivo, and in silico studies of antidiabetic insulin-resistant activity

Setyani,

Murwanti,

Sulaiman

et al. 2023

Journal of Advanced Pharmaceutical Technology &Amp; Research

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Diabetes mellitus (DM) occurs when the body experiences insulin deficiency or is unable to use insulin appropriately, which increases the blood glucose levels over the threshold. Moringa oleifera leaf is a widely used and scientifically proven herbal medicine to treat DM. The demand for the development of new drugs has prompted in vitro, in vivo, and in silico studies of antidiabetic insulin-resistant activity. This study aims to conduct a comprehensive study of the types of flavonoid and nonflavonoid compounds that have antidiabetic activity in insulin resistance mellitus using in vitro, in vivo, and in silico approaches. The literature review was conducted in accordance with the offered reporting items for systematic review. Major bibliographic databases, i.e. Scopus, PubMed, and DOAJ, covering original articles about the aforementioned issues between January 1, 2011 and December 31, 2021 were used. In this study, 274 articles were retrieved, of which 4 were duplicates, and after the titles were read, only 108 were left for analysis. After the abstract screening, 32 articles were eligible for the literature review. The results exhibit that flavonoids, including quercetin and kaempferol, and nonflavonoids, including anthraquinone, cytogluside (glycoside), hemlock tannin, phenolic steroid, and 2-phenylchromenylium (anthocyanins), have potential insulin-resistant antidiabetic activity in vitro, in vivo, and in silico. This has broadened the research into the development of new drugs.

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In vitroand computational studies on the antiglycation activity of compounds isolated from antidiabeticTetracera alnifoliastem bark

Cited by 3 publications

References 46 publications

Acute and sub-acute toxicity study of aqueous and methanol root extract of Tetracera alnifolia in male albino rats

Acute and sub-acute toxicity study of aqueous and methanol root extract of Tetracera alnifolia in male albino rats

Cosmetopoeia of African Plants in Hair Treatment and Care: Topical Nutrition and the Antidiabetic Connection?

Flavonoid from Moringa oleifera leaves revisited: A review article on in vitro, in vivo, and in silico studies of antidiabetic insulin-resistant activity

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