In vitro
 and
 in silico
 studies on clinically important enzymes inhibitory activities of flavonoids isolated from
 Euphorbia pulcherrima

Raza, Muslim; Khan, Momin; Hemeg, Hassan A.; Al-Awthan, Yahya S.; Bahattab, Omar; Bawazeer, Sami; Naz, Sumera; Başoğlu, Faika; Saleem, Muhammad; Khan, Majid; Seyyedamirhossein, Hosseini; Mubarak, Mohammad S.; Orhan, İlkay Erdoğan

doi:10.1080/07853890.2022.2033826

Cited by 9 publications

(3 citation statements)

References 27 publications

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“…Urease inhibition prevents these bacteria from alkalinizing their surroundings. 13,[15][16][17][18][19][20][21][22][23] Hydroxamic acids and their derivatives, which are well-known inorganic urease inhibitors, have been demonstrated to be revocable, slowbinding inhibitors of mutually microbial and plant urease. Unfortunately, acetohydroxamic acid has a long list of negative side effects.…”

Section: Ehsanmentioning

confidence: 99%

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

et al. 2023

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Section: Ehsanmentioning

confidence: 99%

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

et al. 2023

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“…Through the illumination of these antioxidant characteristics, our goal is to enhance comprehension of their possible medicinal and preventive uses in fostering general well-being and extending life expectancy. Research conducted in the scientific community has revealed a significant amount of interest in the antioxidant activity that can be found in various components of Ricinus communicus 24 . The goal of the resent work was to analyze the phytoconstituents present in Ricinus communicus seed extract using aqueous, ethanol, and petroleum ether and evaluate their antioxidant activity.…”

Section: Introductionmentioning

confidence: 99%

Assessment Of Phytochemical Constituent And Antioxidant Capacities Of Ricinus Communicus Seed Extracts

Prashali,

Gurdeep,

Deepak

et al. 2024

eatp

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This study primarily aims to examine the antioxidant properties and phytochemical composition of several solvent extracts of Ricinus communicus seed. solvents such as water, ethanol, and petroleum ether were used to extract the seeds of Ricinus communicus. A variety of compounds were identified in the plant extracts like glycosides, steroids, alkaloids, terpenoids, phenols, tannins, and saponins. After analyzing the data, it was determined that the DPPH activity varied between 52.81±0.015 and 89.36±10 percent. As for the FRAP activity, it was discovered that the aqueous extract had a value of 0.57±0.10, the alcohol extract had a value of 0.72±0.01, on a contrary petroleum ether extract of Ricinus communicus shows 0.84±0.015 FRAP activity. The ethanol extract's anti-oxidant activity was 78.5 ± 0.01 mg/g, High total anti-oxidant capacity of 92.5 ± 0.05 mg/g. in petroleum ether extract. The petroleum ether has 3.95 ± 0.10 mg GA/g of total phenolic content, while the ethanol extract's values were 2.95 ± 0.015 mg GA/g. The results showed that each extract had antioxidant potential while the Petroleum ether extract exhibits stronger antioxidant activity as compared to ethanol and aqueous extracts. This investigation is beneficial for the development of medicines, nutraceutical, and cosmetic industry.

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“…[18][19][20][21][22][23][24][25] Despite the abundance of numerous known urease inhibitors, [26][27][28] novel selenoorganic urease inhibitors based on the 1,2-benzisoselenazol-3(2H)-one scaffold have also emerged as potential drugs. [29] Likewise, the incorporation of selenium into the widely bioactive flavonoids [30][31][32][33][34] have produced benzopyrano-1,2,3-selenadiazoles with significant anticancer activities. [35] Selenadiazoles have claimed special importance, comprising standard and integral features of various active pharmaceutical agents.…”

Section: Introductionmentioning

confidence: 99%

First Exclusive Stereo‐ and Regioselective Preparation of 5‐Arylimino‐1,3,4‐Selenadiazole Derivatives: Synthesis, NMR analysis, and Computational Studies

Moussa

Paz

Khalaf

et al. 2023

Chemistry An Asian Journal

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Isoselenocyanates are valuable coupling partners required for preparing key chemical intermediates and biologically active molecules in an accelerated and effective way. Likewise, (Z)‐2‐oxo‐N‐phenylpropanehydrazonoyl chlorides have been employed in numerous one‐step heteroannulation reactions to assemble the structural core of several various kinds of heterocyclic compounds. Here, we describe the inverse electron demand 1,3‐dipolar cycloaddition reaction of isoselenocyanates with a variety of substituted (Z)‐2‐oxo‐N‐phenylpropanehydrazonoyl chlorides to generate, regioselectively and stereoselectively, a series of 5‐arylimino‐1,3,4‐selenadiazole derivatives comprising a multitude of functional groups on both aryl rings. The synthetic method features gentle room‐temperature conditions, wide substrate scope, and good to high reaction yields. The selenadiazoles were separated by gravity filtration in all instances and chemical structures were validated by multinuclear NMR spectroscopy and high accuracy mass spectral measurements. First conclusive molecular structure elucidation of the observed 5‐arylimino‐selenadiazole regioisomer was verified by single‐crystal X‐ray diffraction analysis. Crystal‐structure measurement was successfully carried out on (Z)‐1‐(4‐(4‐iodophenyl)‐5‐(p‐tolylimino)‐4,5‐dihydro‐1,3,4‐selenadiazol‐2‐yl)ethan‐1‐one and (Z)‐1‐(5‐((4‐methoxyphenyl)imino)‐4‐(4‐(methylthio)phenyl)‐4,5‐dihydro‐1,3,4‐selenadiazol‐2‐yl)ethan‐1‐one. Likewise, the (Z)‐geometry of the hydrazonoyl chloride reactant was proven by X‐ray diffraction studies. As representative examples, crystal‐structure determination was carried out on (Z)‐2‐oxo‐N‐phenylpropanehydrazonoyl chloride and (Z)‐N‐(3,5‐bis(trifluoromethyl)phenyl)‐2‐oxopropanehydrazonoyl chloride. Density functional theory calculations at the B3LYP‐D4/def2‐TZVP level were conducted to support the noted experimental findings and suggested mechanism.

show abstract

In vitro and in silico studies on clinically important enzymes inhibitory activities of flavonoids isolated from Euphorbia pulcherrima

Cited by 9 publications

References 27 publications

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

Flavonoids and related privileged scaffolds as potential urease inhibitors: a review

Assessment Of Phytochemical Constituent And Antioxidant Capacities Of Ricinus Communicus Seed Extracts

First Exclusive Stereo‐ and Regioselective Preparation of 5‐Arylimino‐1,3,4‐Selenadiazole Derivatives: Synthesis, NMR analysis, and Computational Studies

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