In Vitro and In Vivo Evaluation of Oxatomide β-Cyclodextrin Inclusion Complex

Hashem, Fahima; Mostafa, Mohamed M.; Shaker, Mahmoud A.; Nasr, Mohamed

doi:10.1155/2013/629593

Cited by 3 publications

(1 citation statement)

References 21 publications

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“…DSC aids in providing in depth information about the thermal behavior of various materials, such as melting and crystallization performances 46 . When a molecule interacts with the polymer its melting, boiling or sublimation point generally shifts to a different temperature or disappears within the range 47 . DSC (differential scanning colorimeter) thermograms of pectin, blank pectin nanoparticles, and CWO loaded pectin nanoparticles are presented in Fig.…”

Section: Resultsmentioning

confidence: 99%

Impregnation of pectin-cedarwood essential oil nanocapsules onto mini cotton bag improves larvicidal performances

Kala

Sogan

Naik

et al. 2020

Sci Rep

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The use pesticide is one of the indispensable means to combat mosquito borne diseases. However, the repeated use of synthetic pesticides has induced resistance in the vector pest along with undesirable impact on the environment. The biodegradability, non-persistent and user's safety are the root cause to prefer plant-derived pesticides to synthetic ones. The botanical based pesticides tend to degrade rapidly under the influence of several environmental factors. For the feasible application as pesticides, the plant products are formulated either as liquid or as purely solid. Despite well-established formulation technology in pesticide delivery, their handling trouble is being ignored. There is difficulty in liquid formulation of pesticide products, as they are prone to splashing and spillage, resulting in contamination, wastage and direct exposure to skin; whereas a solid formulation tends to produce dust. In the present work, cedarwood (Cedrus deodara) essential oil embedded pectin nanocapsules were produced. The nanocapsules were characterized according to their morphology, size, encapsulation efficiency and thermal stability. Furthermore, the nanocapsules were impregnated onto mini cotton tea bags to be employed as RTU (ready to use) formulation for treating the breeding sites of mosquitoes. The larvicidal activity of the bags treated with pectin-cedar wood nanocapsules was assessed against malaria vector, Anopheles culicifacies and 98% mortality was recorded till 4 weeks, this suggests its potential and hassle free applications in controlling mosquito vector. Global health threats, primarily due to mosquito borne diseases can devastate communities in social and economic terms and hinder development progress 1. Among the various vector borne diseases, malaria is the major public health issue, which transmits through the bite of Anopheles mosquitoes 2. According to the World Health Organization (WHO) 2019 report, malaria causes 228 million morbidity cases and 405,000 number of mortality 3. Anopheles culicifacies is alone accountable for 60-65% of the malaria burden 4. A Mosquito-borne disease remains a challenge since there is no vaccine, and further drug resistance is an increasing threat. Under these circumstances, vector control plays a vital role and often remains the only way to prevent disease outbreaks. The control of malaria vector, Anopheles, relies upon indoor residual spray (IRS) and insecticide treated nets (ITN) 5. Several other control tools have also been proposed including; nano pesticides, microbial pesticides (that are natural occurring bacteria, fungi and viruses) and pesticides of plant origin, which may act as repellents, oviposition deterrents and larvicides etc. 6,7. A new generation biotechnological tool in mosquito control program, based on genetically modified mosquitoes and sterile Insect Technique (SIT) is also being considered 7,8. Despite significant progress so far, further investigations are needed to determine if genetically modification based strategies can be an effective metho...

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Section: Resultsmentioning

confidence: 99%

Impregnation of pectin-cedarwood essential oil nanocapsules onto mini cotton bag improves larvicidal performances

Kala

Sogan

Naik

et al. 2020

Sci Rep

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Comparison of Intravenous Toxicity of Hexaniobium Cluster Complex and its Conjugate with Gamma-cyclodextrin

Pozmogova

Evsiukova

Ivanov

et al. 2019

2019 International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON)

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Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex

Song

Chen²,

Dai

et al. 2022

Molecules

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Curcumin is a natural acidic polyphenol extracted from turmeric with a wide range of biological and pharmacological effects. However, the application of curcumin for animal production and human life is limited by a low oral bioavailability. In this study, natural curcumin was prepared for the curcumin β-cyclodextrin inclusion complex (CUR-β-CD), curcumin solid dispersion (CUR-PEG-6000), and curcumin phospholipid complex (CUR-HSPC) using co-precipitation, melting, and solvent methods, respectively. Curcumin complex formations were monitored using scanning electron microscopy (SEM), X-ray diffraction (XRD), and Fourier transform infrared (FT-IR) techniques via the shifts in the microscopic structure, molecular structure, and crystalline state. Subsequently, twenty-four female beagle dogs were randomly divided into four groups to receive unmodified curcumin and three other curcumin preparations. The validated UPLC–MS assay was successfully applied to pharmacokinetic and bioavailability studies of curcumin in beagle dog plasma, which were collected after dosing at 0 min (predose), 5 min, 15 min, 30 min, 40 min, 50 min, 1.5 h, 3 h, 4.5 h, 5.5 h, 6 h, 6.5 h, 9 h, and 24 h. The relative bioavailabilities of CUR-β-CD, CUR-PEG-6000, and CUR-HSPC were 231.94%, 272.37%, and 196.42%, respectively. This confirmed that CUR-β-CD, CUR-HSPC, and especially CUR-PEG-6000 could effectively improve the bioavailability of curcumin.

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In Vitro and In Vivo Evaluation of Oxatomide β-Cyclodextrin Inclusion Complex

Cited by 3 publications

References 21 publications

Impregnation of pectin-cedarwood essential oil nanocapsules onto mini cotton bag improves larvicidal performances

Impregnation of pectin-cedarwood essential oil nanocapsules onto mini cotton bag improves larvicidal performances

Comparison of Intravenous Toxicity of Hexaniobium Cluster Complex and its Conjugate with Gamma-cyclodextrin

Comparative Study of Preparation, Evaluation, and Pharmacokinetics in Beagle Dogs of Curcumin β-Cyclodextrin Inclusion Complex, Curcumin Solid Dispersion, and Curcumin Phospholipid Complex

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