<i>In vitro</i> and <i>in vivo</i> evaluation of poly(2-methoxyethyl methacrylate-co-acrylic acid)-based microhydrogels for pH-responsive targeted delivery of model drug

Rashid, Zermina; Ranjha, Nazar Muhammad; Rashid, Fareeha; Razzaq, Rabia

doi:10.1080/25740881.2018.1563127

Cited by 2 publications

(2 citation statements)

References 33 publications

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“…The values of n were determined from the slopes and intercepts of the straight line. For the spherical matrices, in case of a Fickian (case-I) drug release mechanism n is <0.43, for anomalous or non-Fickian mechanism n is 0.43<n 0 and a case-II (zero order) drug release mechanism n is >0.85 [20].…”

Section: Release Kinetic Studiesmentioning

confidence: 98%

Sustained released Metformin microparticles for better management of type II diabetes mellitus: in-vitro studies

Raza

Javeria

Rashid

2020

Mater. Res. Express

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This work investigates Ethyl cellulose (EC) and polyethylene glycol (PEG) microparticles for prolonged delivery of Metformin HCl.The microparticles were synthesised by emulsion solvent evaporation technique; characterized for encapsulation efficiency, particle size, flow properties, surface morphology, FTIR, PXRD and drug release pattern; and investigated for the effect of formulation parameters like EC:PEG ratio, drug to polymers ratio and stirring speed on various properties of the microparticles. The drug entrapment efficiency, percent yield, particle size and drug release behaviour were found to be influenced by various formulation parameters.SEM images and size analysis confirmed formation of spherical shaped microparticles, with slightly rough surface and good flowability. FTIR revealed absence of any drug-polymer interaction and PXRD confirmed the molecular dispersion of drug with in microparticles. All the formulations showed sustained drug release pattern at pH 6.8, up to 91.34% ±1.68 metformin was released in 12 h with fickian diffusion mechanism. The designed microparticles could possibly be advantageous in terms of prolonged release, to achieve reduced dose frequency and improved patient compliance.

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Section: Release Kinetic Studiesmentioning

confidence: 98%

Sustained released Metformin microparticles for better management of type II diabetes mellitus: in-vitro studies

Raza

Javeria

Rashid

2020

Mater. Res. Express

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“…Therefore, at pH 7.4, the ionic concentration of carboxylate ions inside the polymeric network matrix increased promptly causing repulsion between the networks which consequently resulted in matrix relaxation and thus rapid increase in the swelling ratio. With an increase of AA content, the equilibrium swelling ratios of the GG-co-AA polymeric networks were also increased at pH 7.4 (Rashid et al, 2019). While at pH 1.2, polymeric network was in non-ionized state due to the hydrogen bonding interactions between the carboxylic hydrophilic groups of AA and hydroxyl groups of GG leading to decreased availability of free hydrophilic groups of polymer with increasing acrylic acid content that ultimately resulted in reduced swellability (Tulain et al, 2018).…”

Section: Swelling Analysis Effect Of Acrylic Acid On Swelling Behavio...mentioning

confidence: 95%

Untitled

2022

Pak. J. Pharm. Sci.,

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Present study was carried out to analyze the impact of three different monomers on release of losartan potassium from graft polymeric network prepared through free radical polymerization. N, N-methylene bis acrylamide was used as crosslinker and potassium persulfate as initiator. Losartan potassium as used as model drug because, it has very small plasma half-life and wide range of applications as an effective and efficient ARB (Angiotensin II Receptor Blockers) causing lower incidence of side -effects. Influence of three different monomers on swelling and in vitro drug release of the delivery system was evaluated at pH 1.2 and 7.4. The polymeric networks were characterized by Fourier transform infrared spectroscopy, Thermogravimetric analysis and Scanning electron microscopy. Polymeric network prepared with acrylic acid and methacrylic acid showed pH responsive behavior and while acrylamide based nexus exhibited pH independent style in swelling and drug release. However, among all the formulations, maximum swelling ratio (25.86) and optimal prolonged drug release (82.92%) was observed for GG-co-AA (M2) polymeric network at intestinal pH 7.4. The results indicated that GG-co-AA polymeric network could be an impending pH-sensitive drug delivery system for Losartan potassium. (M2) designated as formulation code with varying acrylic acid contents

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In vitro and in vivo evaluation of poly(2-methoxyethyl methacrylate-co-acrylic acid)-based microhydrogels for pH-responsive targeted delivery of model drug

Cited by 2 publications

References 33 publications

Sustained released Metformin microparticles for better management of type II diabetes mellitus: in-vitro studies

Sustained released Metformin microparticles for better management of type II diabetes mellitus: in-vitro studies

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