In Vitro and In Vivo Safety of Hyaluronic Acid-Decorated Microparticles for Intravitreal Injection of Palmitoylethanolamide, Citicoline, or Glial-Cell-Derived Neurotrophic Factor
Abstract:The treatment of posterior eye segment diseases through
intravitreal
injection requires repeated injections of an active molecule, which
may be associated with serious side effects and poor patient compliance.
One brilliant strategy to overcome these issues is the use of drug-loaded
microparticles for sustained release, aiming at reducing the frequency
of injections. Therefore, the aim of this work was to assess the safety
features of poly(lactic-co-glycolic acid) (PLGA)-based, hyaluronic
acid-decorated micro… Show more
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