In vitroandin vivoimmunomodulatory and anti-ulcerogenic activities ofTeucrium ramosissimumextracts

Sghaïer, Mohamed Ben; Krifa, Mounira; Mensi, R.; Bhouri, Wissem; Ghedira, Kamel; Chekir‐Ghedira, Leila

doi:10.3109/1547691x.2011.595741

Cited by 10 publications

(4 citation statements)

References 59 publications

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“…It is an area of active interest for discovering immunomodulatory agents from medicinal plant origins for immunosuppressive diseases treatment. A large number of Traditional Chinese medicines have been shown to possess immunomodulating activities [ 12 , 13 ]. Ardisia japonica has been employed clinically with the combination of other Chinese herbal medicines to treat patients with tuberculosis by improving host immunity [ 28 ].…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, a variety of medicinal plants have been shown to possess modulating functions of the innate and adaptive immune systems and have anti-oxidative characteristics [ 12 , 13 ]. In fact, Chinese herbal medicines have been widely used to protect against the side-effects associated with chemotherapeutics drugs in cancer treatment [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

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Protective Effect of Bergenin against Cyclophosphamide-Induced Immunosuppression by Immunomodulatory Effect and Antioxidation in Balb/c Mice

Dong

Sun

et al. 2018

Molecules

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In this study, the aim was to investigate the effect of bergenin on immune function and antioxidation in cyclophosphamide (Cy)-induced immunosuppressed mice. Firstly, we estimated its effect on immune organs. Histological analysis and indexes of immune organs showed that cyclophosphamide exhibited spleen and thymus injury compared with the normal control, which was alleviated by bergenin. Secondly, bergenin also enhanced the humoral immune function through increasing the level of IgM and IgG in serum. Thirdly, bergenin also enhanced the cellular immune function. The results indicate that bergenin increased peritoneal macrophage functions, the proliferation of T and B lymphocytes, NK and CTL cell activities, and T (CD4+ and CD8+) lymphocyte subsets. Besides, bergenin also had the ability to modulate the Th1/Th2 balance. Moreover, bergenin prevented the Cy-induced decrease in numbers of peripheral RBC, WBC and platelets, providing supportive evidence for their anti-leukopenia activities. Finally, bergenin also reversed the Cy-induced decrease in the total antioxidant capacity including activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GSH-Px). In conclusion, bergenin protected against Cy-induced adverse reactions by enhancing humoral and cellular immune functions and augmenting antioxidative activity and could be considered as a potential immunomodulatory agent.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Protective Effect of Bergenin against Cyclophosphamide-Induced Immunosuppression by Immunomodulatory Effect and Antioxidation in Balb/c Mice

Dong

Sun

et al. 2018

Molecules

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“…Some immunoactive substances have been implicated in many Teucrium species studied 38,39 . Methanolic, aqueous, and total flavonoid extracts of T. ramosissimum have been found to induce splenocyte proliferation and enhance LPS-induced proliferative response 22 . Phenolic acids and flavonoids contained in T. polium and T. scordium methanolic extracts may have antimutagenic and proapoptotic effects, protecting lymphocytes from mitomycin C-induced genotoxicity 40 .…”

Section: Discussionmentioning

confidence: 99%

Teucrium montanum extract drives effector and memory differentiation of CD8+ T cells

Li,

Ma,

Wang

et al. 2023

Biomed. Res. Ther.

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Introduction:Teucrium montanum has been traditionally used for immune system strengthening. However, T cell-related mechanisms of the Teucrium species remain poorly understood. In this study, we investigated the impact of T. montanum extracts and their fractions in stimulating proliferation and, more importantly, in differentiation into effectors and memory T cells. Methods: The dried, aerial part of T. montanum was extracted in four different solvents: petroleum ether, dichloromethane, ethyl acetate, and methanol. A total of 67 fractions were subsequently collected from the dichloromethane extract in a stepwise gradient system of petroleum ether/acetone followed by methanol. An Alamar Blue assay and flow cytometry were employed to characterize the influence on T cell response by the plant extracts or fractions. Results: The dichloromethane extract showed promotive effects on the proliferation and activation of total lymphocytes, and this was more prominent in CD8 + T cells. Among the 67 fractions from the dichloromethane extract, nine were found to demonstrate pro-proliferative activity. Further testing revealed that three methanolic or acetone subfractions out of the nine fractions were able to either promote effector/effector memory differentiation of primed CD8 + T cells or skew the T cells into a central memory phenotype. Conclusion: Our results suggest that T. montanum can drive proliferation of T cells and regulate the development of effector and memory populations, apparently corroborating the reported immunological benefits of T. montanum.

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“…In Africa, traditional remedies made from plants play an important role in the health of millions of people [2], and novel bioactive natural products with intriguing chemical structures and pharmacological properties have been identified in medicinal plants found in Africa [3]. For example, many of these plant materials are known to enhance the innate immune system and modulate host defense responses [4–6]. On the other hand, our understanding of the active principles of plant-derived medicines used widely in African countries is not extensive.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum

Schepetkin

Kouakou

Yapi³

et al. 2013

International Immunopharmacology

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Extracts of leaves of different species of the genus Combretum have been used historically to treat a variety of medicinal problems. However, little is known about the active components conferring therapeutic properties to these extracts. In the present studies, we evaluated biochemical properties and immunomodulatory activity of polysaccharides isolated from the leaves of Combretum racemosum. Water-soluble polysaccharides from leaves of C. racemosum were extracted and fractionated by DEAE-cellulose and Diaion HP-20 to obtain a Diaion-bound fraction, designated Combretum polysaccharide-acidic bound or CP-AB, which was eluted with methanol, and an unbound fraction, designated as CP-AU. Molecular weight determination, sugar analysis, and other physical and chemical characterization of the fractions were performed. Fraction CP-AU (mol. weight 5.0 kDa) contained type II arabinogalactan and had potent immunomodulatory activity, inducing the production of interleukin (IL)-1β, -6, -10, and tumor necrosis factor-α (TNF-α) by human peripheral blood mononuclear cells (PBMC) and MonoMac-6 monocytic cells. Likewise, intraperitoneal administration of CP-AU increased in vivo serum levels of IL-6 and monocyte chemoattractant protein-1 (MCP-1) in mice. CP-AU-induced secretion of TNF-α in PBMC was prevented by Toll-like receptor 4 (TLR4) antagonist LPS-RS. Treatment with CP-AU induced phosphorylation of Akt2, Akt3, GSK-3β, HSP27, mTOR, and all p38 MAPK isoforms (α, β, δ, and γ), as well as stimulation of AP-1/NF-κB transcriptional activity. In addition, CP-AU effectively agglutinated erythrocytes from several species, including human, mouse, and rabbit. In contrast, fraction CP-AB was inactive in all biological tests, including cytokine production and hemagglutination. These data suggest that at least part of the beneficial therapeutic effects reported for the water extracts of leaves from C. racemosum are due to modulation of leukocyte functions.

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In vitroandin vivoimmunomodulatory and anti-ulcerogenic activities ofTeucrium ramosissimumextracts

Cited by 10 publications

References 59 publications

Protective Effect of Bergenin against Cyclophosphamide-Induced Immunosuppression by Immunomodulatory Effect and Antioxidation in Balb/c Mice

Protective Effect of Bergenin against Cyclophosphamide-Induced Immunosuppression by Immunomodulatory Effect and Antioxidation in Balb/c Mice

Teucrium montanum extract drives effector and memory differentiation of CD8+ T cells

Immunomodulatory and hemagglutinating activities of acidic polysaccharides isolated from Combretum racemosum

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