<i>In vitro</i> and <i>in vivo</i> study of aspirin loaded, electrospun polycaprolactone–maltodextrin membrane for enhanced skin tissue regeneration

Movahedi, Mehdi; Salehi, Amin Orash Mahmoud; Moezi, Davoud; Yarahmadian, Reyhaneh

doi:10.1080/00914037.2021.1962877

Cited by 10 publications

(5 citation statements)

References 78 publications

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“…Many of them investigate single layer tissues, under the consideration of a single set of tissue optical properties (absorption and reduced scattering coefficients), but realistic biological tissues have many layers [29, 30]. Therefore, several models were developed to investigate the two‐layer and multilayered tissue in vivo and ex vivo [31]. The random walk theory was proposed by Nossal et al to study the propagation of light in layered tissue.…”

Section: Methodsmentioning

confidence: 99%

Diffused reflectance measurements to detect tattoo ink location in skin using the crossover point

Rudraiah

Duadi

Fixler

2022

Journal of Biophotonics

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Tattoos are highly trendy in western culture, but many people regret their tattoos for many reasons. It is essential to be aware of the ink location in advance to reduce the long and short-term side effects. In this study, diffuse reflectance (DR) experiments were conducted on two-layer (2L) tissue-mimicking phantoms, where ink was sandwiched between the layers. An appreciable difference in the DR profile was found between the 2L phantom with and without the tattoo ink using the crossover point (Cp) method. Our technique was applied to ex vivo porcine skin. A point of intersection was found, between the skin and the tattooed skin. In the shorter wavelengths (500-600 nm), a distinguishable 2L behavior was found, and in longer wavelengths (600-850 nm), a single layer behavior was found between the tattooed skin before and after the intersection. In biological tissue, this Cp indeed finds the tattoo ink without harm to the surrounding skin.

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Section: Methodsmentioning

confidence: 99%

Diffused reflectance measurements to detect tattoo ink location in skin using the crossover point

Rudraiah

Duadi

Fixler

2022

Journal of Biophotonics

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“…The electrospinning technique is known as a versatile platform to produce scaffolds made of bers in the range of nano to micrometers with optimizable textural properties, such as high porosity and surface area while tailoring mechanical properties. It can be a potential method to mimic the shapes of different tissues/extracellular matrix (ECM) biologically by employing various types of materials from natural or synthetic sources [15][16][17]. It should be noted that the bers produced by the electrospun technique are capable of inducing cell/scaffold interactions that ensure an appropriate rate of penetration/removal of nutrients/wastes resulting from cell activities [18][19][20].…”

Section: Introductionmentioning

confidence: 99%

A core-shell Electrospun Scaffold of polyhydroxybutyrate-starch/halloysite Nanotubes Containing Extracellular Matrix and Chitosan for Articular Cartilage Tissue Engineering Application

Movahedi

Karbasi

2023

J Polym Environ

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Electrospinning is known as a versatile technique for articular cartilage tissue regeneration (ACTR) due to its excellent potential to produce a brous scaffold that mimics the extracellular matrix (ECM) of native tissue. However, there is a need to promote the biological performance of scaffolds maintaining their mechanical strength. In this study, a core-shell polyhydroxybutyrate (PHB)-starch/halloysite nanotubes (HNTs) @ ECM-chitosan (Cs) scaffold was prepared via the coaxial electrospinning method. The results exhibited a narrower ber diameter of up to 164 ± 24 nm with an appropriate pore size and porosity after incorporating Cs and ECM. Moreover, the core-shell scaffold showed an enhanced Young's modulus up to 4.45 ± 0.1 MPa that could support chondrocyte cell growth. After that, the wettability and in vitro degradability of the core-shell scaffold were induced due to the hydrophilic nature of shell components. Also, chondrocyte cells had more viability and attachment on the core-shell structure proving the potential of core-shell bers for biomedical applications. In conclusion, the results showed that the core-shell

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Section: Introductionmentioning

confidence: 99%

A core-shell electrospun scaffold including extracellular matrix and chitosan to promote articular cartilage tissue regeneration

Movahedi

Karbasi

2023

Preprint

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Electrospinning is known as a versatile technique for articular cartilage tissue regeneration (ACTR) due to its excellent potential to produce a fibrous scaffold that mimics the extracellular matrix (ECM) of native tissue. However, there is a need to promote the biological performance of scaffolds maintaining their mechanical strength. In this study, a core-shell polyhydroxybutyrate (PHB)-starch/halloysite nanotubes (HNTs) @ ECM-chitosan (Cs) scaffold was prepared via the coaxial electrospinning method. The results exhibited a narrower fiber diameter of up to 164 ± 24 nm with an appropriate pore size and porosity after incorporating Cs and ECM. Moreover, the core-shell scaffold showed an enhanced Young’s modulus up to 4.45 ± 0.1 MPa that could support chondrocyte cell growth. After that, the wettability and in vitro degradability of the core-shell scaffold were induced due to the hydrophilic nature of shell components. Also, chondrocyte cells had more viability and attachment on the core-shell structure proving the potential of core-shell fibers for biomedical applications. In conclusion, the results showed that the core-shell structured PHB-starch/HNTs @ ECM-Cs could be a suitable candidate for further trial towards ACTR.

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In vitro and in vivo study of aspirin loaded, electrospun polycaprolactone–maltodextrin membrane for enhanced skin tissue regeneration

Cited by 10 publications

References 78 publications

Diffused reflectance measurements to detect tattoo ink location in skin using the crossover point

Diffused reflectance measurements to detect tattoo ink location in skin using the crossover point

A core-shell Electrospun Scaffold of polyhydroxybutyrate-starch/halloysite Nanotubes Containing Extracellular Matrix and Chitosan for Articular Cartilage Tissue Engineering Application

A core-shell electrospun scaffold including extracellular matrix and chitosan to promote articular cartilage tissue regeneration

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