<i>In vitro</i> and <i>in vivo</i> antitumor activity of novel half-sandwich ruthenium complexes containing quinoline derivative ligands

He, Xiangdong; Kandawa‐Schulz, Martha; Shao, Guoqiang; Wang, Yihong

doi:10.1039/d2dt03317h

Dalton Trans.

2023

DOI: 10.1039/d2dt03317h

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In vitro and in vivo antitumor activity of novel half-sandwich ruthenium complexes containing quinoline derivative ligands

Xiangdong He

Martha Kandawa‐Schulz

Guoqiang Shao

et al.

Abstract: A series of half-sandwich ruthenium complexes containing quinoline derivative ligands were synthesized, which have excellent antitumor toxicity to a variety of cell lines and can localize lysosomes. The damage of...

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2024

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Cited by 9 publications

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Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells

Yang,

Li,

et al. 2024

Drug Development Research

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Four lanthanide complexes with 8‐hydroxyquinoline‐2‐aldehyde‐2‐hydrazinopyridine (H‐L1), 8‐hydroxyquinoline‐2‐aldehyde‐2‐hydrazimidazole (H‐L2): [Sm(L1)2][Sm(L1)(NO3)3]·CHCl3·2CH3OH (1), [Gd(L1)2][Gd(L1)(NO3)3]·CHCl3·2CH3OH (2), [Sm(L2)(NO3)2]2·CH3OH (3), and [Eu(L2)(NO3)2]2·CH3OH (4) were synthesized and characterized. In vitro cytotoxicity evaluation showed that the ligands and four lanthanide complexes exhibited cytotoxicity to the five tested tumor cell lines. Among them, complex 1 showed the best antiproliferative activity against NCI‐H460 tumor cells. Mechanistic studies demonstrated that complex 1 arrested the cell cycle of NCI‐H460 cells in G1 phase and induced mitochondria‐mediated apoptosis, which resulted in the loss of mitochondrial membrane potential, enhanced intracellular Ca2+ levels and reactive oxygen species generation. In addition, complex 1 affected the expression levels of intracellular apoptosis‐related proteins and activated the caspase‐3/9 in NCI‐H460 cells. Therefore, complex 1 is a potential anticancer agent.

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Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells

Yang,

Li,

et al. 2024

Drug Development Research

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Quinoline-based metal complexes: Synthesis and applications

Kumar,

Thakur,

Sachin

et al. 2024

Coordination Chemistry Reviews

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Ionic copolymer-modified hexagonal carbon nitride tube as a high-performance catalyst for regioselective synthesis of hexahydroquinoline frameworks

Shafaati,

Safaei-Ghomi,

Elyasi

2024

Colloids and Surfaces A: Physicochemical and Engineering Aspect

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In vitro and in vivo antitumor activity of novel half-sandwich ruthenium complexes containing quinoline derivative ligands

Abstract: A series of half-sandwich ruthenium complexes containing quinoline derivative ligands were synthesized, which have excellent antitumor toxicity to a variety of cell lines and can localize lysosomes. The damage of...

Cited by 9 publications

References 42 publications

Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells

Sm(Ⅲ), Gd(Ⅲ), and Eu(Ⅲ) complexes with 8‐hydroxyquinoline derivatives as potential anticancer agents via inhibiting cell proliferation, blocking cell cycle, and inducing apoptosis in NCI‐H460 cells

Quinoline-based metal complexes: Synthesis and applications

Ionic copolymer-modified hexagonal carbon nitride tube as a high-performance catalyst for regioselective synthesis of hexahydroquinoline frameworks

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