<i>In vitro</i> anti-enteroviral activity of stilbenoids isolated from the leaves of <i>Macaranga barteri</i>

Segun, Peter A.; Ogbole, Omonike O.; Akinleye, Toluwanimi E.; Faleye, Temitope Oluwasegun Cephas; Ja, Aznar

doi:10.1080/14786419.2019.1644505

Cited by 19 publications

(12 citation statements)

References 17 publications

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“…The pure compounds were tested against echovirus 7, 13 and 19 serotypes and were inactive against echovirus E13, while a good activity was reported on E19. In particular, vadelianin exhibited an IC 50 value of 0.0036 nM and the best selectivity profile with SI value of 216.7 [95].…”

Section: Compoundmentioning

confidence: 97%

“…Conversely, cis-resveratrol exhibited significant Segun et al reported the anti-enteroviral activity of three stilbenoids (mappain, vadelianin and schweinfurthin G; Fig. 17) isolated from the leaves of Macaranga barteri (Euphorbiaceae) [95]. The pure compounds were tested against echovirus 7, 13 and 19 serotypes and were inactive against echovirus E13, while a good activity was reported on E19.…”

Section: Compoundmentioning

confidence: 99%

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Natural and nature-inspired stilbenoids as antiviral agents

Mattio

Catinella

Pinto

et al. 2020

European Journal of Medicinal Chemistry

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Viruses continue to be a major threat to human health. In the last century, pandemics occurred and resulted in significant mortality and morbidity. Natural products have been largely screened as source of inspiration for new antiviral agents. Within the huge class of plant secondary metabolites, resveratrolderived stilbenoids present a wide structural diversity and mediate a great number of biological responses relevant for human health. However, whilst the antiviral activity of resveratrol has been extensively studied, little is known about the efficacy of its monomeric and oligomeric derivatives. The purpose of this review is to provide an overview of the achievements in this field, with particular emphasis on the source, chemical structures and the mechanism of action of resveratrol-derived stilbenoids against the most challenging viruses. The collected results highlight the therapeutic versatility of stilbene-containing compounds and provide a prospective insight into their potential development as antiviral agents.

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Section: Compoundmentioning

confidence: 97%

Section: Compoundmentioning

confidence: 99%

Natural and nature-inspired stilbenoids as antiviral agents

Mattio

Catinella

Pinto

et al. 2020

European Journal of Medicinal Chemistry

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“…As an example, the strong in vitro activity of extracts of Macaranga barteri against E7 and E19 echoviruses suggests that it can be an effective therapeutic agent for enteroviral infections such as encephalitis (Ogbole et al, 2018). However, among all the components, three stilbenoids (especially vedelianin) isolated from M. barteri extracts are largely responsible for the anti-viral activity against echoviruses (Segun et al, 2019). Similarly, other stilbenes such as Resveratrol and trans-arachidin isolated from grapes and the hairy root culture of peanut are capable of reducing the replication rate of the African swine fever virus (ASFV) and RVs, respectively (Abba et al, 2015;Ball et al, 2015).…”

Section: Medicinal Plants and Their Extracts As An Anti-viral Agentmentioning

confidence: 99%

Natural Plant Products: A Less Focused Aspect for the COVID-19 Viral Outbreak

et al. 2020

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The sudden emergence of COVID-19 caused by a novel coronavirus (nCoV) led the entire world to search for relevant solutions to fight the pandemic. Although continuous trials are being conducted to develop precise vaccines and therapeutic antibodies, a potential remedy is yet to be developed. Plants have largely contributed to the treatment of several human diseases and different phytoconstituents have been previously described to impede the replication of numerous viruses. Despite the previous positive reports of plant-based medications, no successful clinical trials of phyto-anti-COVID drugs could be conducted to date. In this article, we discuss varying perspectives on why phyto-anti-viral drug clinical trials were not successful in the case of COVID-19. The issue has been discussed in light of the usage of plant-based therapeutics in previous coronavirus outbreaks. Through this article, we aim to identify the disadvantages in this research area and suggest some measures to ensure that phytoconstituents can efficiently contribute to future random viral outbreaks. It is emphasized that if used strategically phyto-inhibitors with pre-established clinical data for other diseases can save the time required for long clinical trials. The scientific community should competently tap into phytoconstituents and take their research up to the final stage of clinical trials so that potential phyto-anti-COVID drugs can be developed.

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“…Most of the plants that found application in ethnomedicine have been documented based on their promising activities against multiple disease-causing microorganisms [ 7 , 8 ]. Research efforts are expediting for better functional understanding of medicinal plants, and this has provided a model for about 25–50% of the marketed drugs [ 9 ]. Antimicrobial activities of useful plants vary; the majority act in synergy [ 10 ], reducing the side effect of synthetic drugs [ 11 ], while others act as quorum quenchers [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Importance of Medicinal Plants in Nigeria

Ugboko

Nwinyi

Oranusi

et al. 2020

The Scientific World Journal

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Despite the success of antibiotic discovery, infectious diseases remain the second leading source of death worldwide, while the resistance to antibiotics is among the significant problems in the twenty-first century. Medicinal plants are very rich in phytochemicals which can be structurally optimized and processed into new drugs. Nigeria enjoys a diverse collection of medicinal plants, and joint research has ascertained the efficacy of these plants. Plants such as guava (Psidium guajava), ginger (Zingiber officinale), neem (Azadirachta indica), and moringa (Moringa oleifera) have been found to exhibit broad range of antimicrobial activities. Studies on Nigerian plants have shown that they contain alkaloids, polyphenols, terpenes, glycosides, and others with possible therapeutic potentials. The antimicrobial activities of some new compounds such as alloeudesmenol, hanocokinoside, orosunol, and 8-demethylorosunol, identified from medicinal plants in Nigeria, are not yet explored. Further investigation and optimization of these compounds will facilitate the development of new sets of pharmacologically acceptable antimicrobial agents. This review study revealed the efficacy of medicinal plants as an alternative therapy in combating and curtailing the development and survival of multidrug-resistant pathogens coupled with the toxic effects of some antibiotics. Due to enormous therapeutic possibilities buried in medicinal plants, there is a need for more research into unique fingerprints and novel compounds that can provide cure to the neglected tropical diseases (NTDs) of humans and animals facing Africa, especially Nigeria.

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In vitro anti-enteroviral activity of stilbenoids isolated from the leaves of Macaranga barteri

Cited by 19 publications

References 17 publications

Natural and nature-inspired stilbenoids as antiviral agents

Natural and nature-inspired stilbenoids as antiviral agents

Natural Plant Products: A Less Focused Aspect for the COVID-19 Viral Outbreak

Antimicrobial Importance of Medicinal Plants in Nigeria

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